Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4398-4415

  Han, Q ^a   Dominguez, C ^a,b   Stouten, P F W ^a,c   Park, J M ^a   Duffy, D E ^a   Galemmo Jr , R A ^a   Rossi, K A ^a   Alexander, R S ^a   Smallwood, A M ^a   Wong, P C ^a   Wright, M M ^a   Luettgen, J M ^a   Knabb, R M ^a   Wexler, R R ^a  

^a DUPONT COMPANY   (United States)

^b AMGEN INC   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (5 AMIDINO 1H INDOL 3 YL) N [2' (AMINOSULFONYL) 3 BROMO (1,1' BIPHENYL) 4 YL]ACETAMIDE; 2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; AMIDINOBENZIMIDAZOLE DERIVATIVE; AMIDINOINDAZOLE DERIVATIVE; AMIDINOINDOLE DERIVATIVE; BICYCLO COMPOUND; BLOOD CLOTTING FACTOR 10A INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

AMIDINES; ANIMALS; BENZIMIDAZOLES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DESIGN; FACTOR XA; FIBRINOLYTIC AGENTS; HUMANS; INDAZOLES; INDOLES; MODELS, MOLECULAR; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRYPSIN; VENOUS THROMBOSIS;

EID: 0034676315     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000113t     Document Type: Article

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