D-Cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion

Learning and Memory

Volumn 16, Issue 11, 2009, Pages 682-686

  Akirav, Irit ^a   Segev, Amir ^a   Motanis, Helen ^a   Maroun, Mouna ^a  

^a UNIVERSITY OF HAIFA   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSERINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; BASOLATERAL AMYGDALA; CONDITIONED TASTE AVERSION; CONDITIONING; CONTROLLED STUDY; FEAR; INFUSION; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; STRESS; TASTE AVERSION;

AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; ANTIMETABOLITES; AVOIDANCE LEARNING; CONDITIONING (PSYCHOLOGY); CYCLOSERINE; EXPLORATORY BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; FEAR; LEARNING DISORDERS; LITHIUM CHLORIDE; LOCOMOTION; MALE; RATS; RATS, WISTAR; STRESS, PSYCHOLOGICAL; TASTE;

EID: 70350644903     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.1565109     Document Type: Article

References (36)

1. A agonist in the amygdala. Neuropsychopharmacology 32: 542-550.
2. Akirav I, Maroun M. 2007. The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear. Neural Plast 2007. doi: 10.1155/2007/30873. (Pubitemid 351210896)
3. Blanchard DC, Blanchard RJ. 1972. Innate and conditioned reactions to threat in rats with amygdaloid lesions. J Comp Physiol Psychol 81: 281-290.
4. Cammarota M, Bevilaqua LR, Vianna MR, Medina JH, Izquierdo I. 2007. The extinction of conditioned fear: Structural and molecular basis and therapeutic use. Rev Bras Psiquiatr 29: 80-85. (Pubitemid 46572469)
5. Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. 1993. Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 50: 295-305. (Pubitemid 23115373)
6. Cordero MI, Venero C, Kruyt ND, Sandi C. 2003. Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats: Evidence for a role of corticosterone. Horm Behav 44: 338-345. (Pubitemid 37378213)
7. Davis M. 1992. The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15: 353-375.
8. Davis M, Ressler K, Rothbaum BO, Richardson R. 2006. Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biol Psychiatry 60: 369-375. (Pubitemid 44215855)
9. Falls WA, Miserendino MJ, Davis M. 1992. Extinction of fear potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala. J Neurosci 12: 854-863.
10. Ganon-Elazar E, Akirav I. 2009. Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci 29: 11078-11088.
11. Garcia R, Spennato S, Nilsson-Todd L, Moreau JL, Deschaux O. 2007. Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats. Neurobiol Learn Mem 89: 560-566.
12. Heresco-Levy U, Kremer I, Javitt DC, Goichman R, Reshef A, Blanaru M, Cohen T. 2002. Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol 5: 301-307.
13. Hofmann SG, Pollack MH, Otto MW. 2006. Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine. CNS Drug Rev 12: 208-217. (Pubitemid 46047788)
14. Izquierdo A, Wellman CL, Holmes A. 2006. Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J Neurosci 6: 5733-5738. (Pubitemid 44315265)
15. Kim JJ, Diamond DM. 2002. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci 3: 453-462.
16. Kim J, Fanselow MS, DeCola JP, Landeira-Fernandez J. 1992. Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV. Behav Neurosci 106: 591-596.
17. Ledgerwood L, Richardson R, Cranney J. 2003. Effects of D-cycloserine on extinction of conditioned freezing. Behav Neurosci 117: 341-349. (Pubitemid 36384252)
18. Ledgerwood L, Richardson R, Cranney J. 2005. D-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction. Biol Psychiatry 57: 841-847. (Pubitemid 40488352)
19. LeDoux JE. 1993. Emotional memory: In search of systems and synapses. Ann N Y Acad Sci 17: 149-157.
20. Lu KT, Walker DL, Davis M. 2001. Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J Neurosci 15: 1-5.
21. Lutz B. 2007. The endocannabinoid system and extinction learning. Mol Neurobiol 36: 92-101.
22. Maren S. 1999. Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats. J Neurosci 1: 8696-8703. (Pubitemid 30226788)
23. Maren S, Chang CH. 2006. Recent fear is resistant to extinction. Proc Natl Acad Sci 21: 18020-18025.
24. Maroun M, Akirav I. 2008. Arousal and stress effects on consolidation and reconsolidation of recognition memory. Neuropychopharmacology 33: 394-405. (Pubitemid 350243343)
25. McGaugh JL. 2004. The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 27: 1-28.
26. McGaugh JL, Introini-Collison IB, Cahill LF, Castellano C, Dalmaz C, Parent MB, Williams CL. 1993. Neuromodulatory systems and memory storage: Role of the amygdala. Behav Brain Res 20: 81-90. (Pubitemid 24024047)
27. Miracle AD, Brace MF, Huyck KD, Singler SA, Wellman CL. 2006. Chronic stress impairs recall of extinction of conditioned fear. Neurobiol Learn Mem 85: 213-218.
28. Nader K, Schafe GE, LeDoux JE. 2000. The labile nature of consolidation theory. Nat Rev Neurosci 1: 216-219.
29. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. Elsevier, Oxford, UK.
30. Ressler KJ, Rothbaum BO, Tannebaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M. 2004. Cognitiveenhances as adjuncts to psychotherapy: Use of D-Cycloserine in phobics to facilitate extinction of fear. Arch Gen Psychiatry 61: 1136-1144. (Pubitemid 39463415)
31. Shors TJ, Weiss C, Richard F. 1992. Stress-induced facilitation of classical conditioning. Science 257: 537-539.
32. Shumake J, Barrett D, Gonzalez-Lima F. 2005. Behavioral characteristics of rats predisposed to learned helplessness: Reduced reward sensitivity, increased novelty seeking, and persistent fear memories. Behav Brain Res 164: 222-230. (Pubitemid 41337877)
33. Thiel CM, Müller CP, Huston JP, Schwarting RK. 1999. High versus low reactivity to a novel environment: Behavioural, pharmacological and neurochemical assessments. Neuroscience 93: 243-251.
34. Walker DL, Ressler KJ, Lu KT, Davis M. 2002. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 22: 2343-2351. (Pubitemid 35386533)
35. Yamamoto S, Morinobu S, Fuchikami M, Kurata A, Kozuru T, Yamawaki S. 2008. Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD. Neuropsychopharmacology 33: 2108-2116. (Pubitemid 351992081)
36. Yang YL, Lu KT. 2005. Facilitation of conditioned fear extinction by D-cycloserine is mediated by mitogen activated protein kinase and PI-3 kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdale. Neuroscience 134: 247-260.