메뉴 건너뛰기




Volumn 33, Issue 5, 2009, Pages 332-338

A new era in iron chelation therapy: The design of optimal, individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients

Author keywords

Deferasirox (DFRA); Deferiprone (L1); Deferoxamine (DFO); Normal iron stores; Optimal dose protocols; Thalassemia

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN;

EID: 70350643863     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630260903217182     Document Type: Conference Paper
Times cited : (32)

References (18)
  • 1
    • 33745531237 scopus 로고    scopus 로고
    • Effective combination therapy of deferiprone and deferoxamine for the rapid clearance of excess cardiac iron and the prevention of heart disease in thalassemia
    • The protocol of the International Committee on Oral Chelators
    • Kolnagou A, Kontoghiorghes GJ. Effective combination therapy of deferiprone and deferoxamine for the rapid clearance of excess cardiac iron and the prevention of heart disease in thalassemia. The protocol of the International Committee on Oral Chelators. Hemoglobin. 2006;30(2):239-249.
    • (2006) Hemoglobin , vol.30 , Issue.2 , pp. 239-249
    • Kolnagou, A.1    Kontoghiorghes, G.J.2
  • 2
    • 39349096186 scopus 로고    scopus 로고
    • Long term comparative studies in thalassemia patients treated with deferoxamine or deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols
    • Kolnagou A, Economides Ch, Eracleous E, Kontoghiorghes GJ. Long term comparative studies in thalassemia patients treated with deferoxamine or deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols. Hemoglobin. 2008;32(1-2):41-47.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 41-47
    • Kolnagou, A.1    Ch, E.2    Eracleous, E.3    Kontoghiorghes, G.J.4
  • 3
    • 0026507913 scopus 로고
    • Advances in oral iron chelation in man
    • Kontoghiorghes GJ. Advances in oral iron chelation in man. Int J Haematol. 1992;55(1):27-38.
    • (1992) Int J Haematol , vol.55 , Issue.1 , pp. 27-38
    • Kontoghiorghes, G.J.1
  • 4
    • 0347363715 scopus 로고    scopus 로고
    • Combined therapy with desferrioxamine and deferiprone in thalassemic patients: Effect on urinary iron excretion
    • Kattamis A, Kassou C, Berdousi H, et al. Combined therapy with desferrioxamine and deferiprone in thalassemic patients: effect on urinary iron excretion. Haematologica. 2003;88(12):1423-1425.
    • (2003) Haematologica , vol.88 , Issue.12 , pp. 1423-1425
    • Kattamis, A.1    Kassou, C.2    Berdousi, H.3
  • 5
    • 34447316694 scopus 로고    scopus 로고
    • Light and shadows in the iron chelation treatment of haematological diseases
    • Maggio A. Light and shadows in the iron chelation treatment of haematological diseases. Br J Haematol. 2007;138(3):407-421.
    • (2007) Br J Haematol , vol.138 , Issue.3 , pp. 407-421
    • Maggio, A.1
  • 6
    • 39349091615 scopus 로고    scopus 로고
    • Myocyte damage and loss of myofibers is the potential mechanism of iron overload toxicity in congestive cardiac failure in thalassemia. Complete reversal of the cardiomyopathy and normalization of iron load by deferiprone
    • Kolnagou A, Michaelides Y, Kontos C, et al. Myocyte damage and loss of myofibers is the potential mechanism of iron overload toxicity in congestive cardiac failure in thalassemia. Complete reversal of the cardiomyopathy and normalization of iron load by deferiprone. Hemoglobin. 2008;32(1- 2):17-28.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 17-28
    • Kolnagou, A.1    Michaelides, Y.2    Kontos, C.3
  • 7
    • 39349086377 scopus 로고    scopus 로고
    • Ethical issues and risk/benefit assessment on iron chelation therapy: Advances with deferiprone/deferoxamine combination and concerns on deferasirox's safety, efficacy and costs
    • Kontoghiorghes GJ. Ethical issues and risk/benefit assessment on iron chelation therapy: advances with deferiprone/deferoxamine combination and concerns on deferasirox's safety, efficacy and costs. Hemoglobin. 2008;32(1-2):1-15.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 1-15
    • Kontoghiorghes, G.J.1
  • 8
    • 57449098280 scopus 로고    scopus 로고
    • Transparency and access to full information for the fatal or serious toxicity risks, low efficacy and high price of deferasirox, could increase the prospect of improved iron chelation therapy worldwide
    • Kontoghiorghes GJ. Transparency and access to full information for the fatal or serious toxicity risks, low efficacy and high price of deferasirox, could increase the prospect of improved iron chelation therapy worldwide. Hemoglobin. 2008;32(6):608-615.
    • (2008) Hemoglobin , vol.32 , Issue.6 , pp. 608-615
    • Kontoghiorghes, G.J.1
  • 9
    • 27744544284 scopus 로고    scopus 로고
    • Advances in iron overload therapies Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NAll and their combinations
    • Kontoghiorghes GJ, Eracleous E, Economides Ch, Kolnagou A. Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NAll and their combinations. Curr Med Chem. 2005;12(23):2663-2681.
    • (2005) Curr Med Chem , Issue.12-23 , pp. 2663-2681
    • Kontoghiorghes, G.J.1    Eracleous, E.2    Ch, E.3    Kolnagou, A.4
  • 10
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in b-thalassemia major patients with asymptomatic myocardial siderosis
    • Pennell DJ, Berdoukas V, Karagiorga M, et al. Randomized controlled trial of deferiprone or deferoxamine in b-thalassemia major patients with asymptomatic myocardial siderosis. Blood. 2006;107(9):3738-3744.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3
  • 11
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown E, Olivieri NF, Giardina PJV, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003;361(9369):1597-1602.
    • (2003) Lancet , vol.361 , Issue.9369 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.V.3
  • 12
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti C, Cappellini MD, De Stefano P, et al. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood. 2006;107(9):3733-3737.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3
  • 13
    • 0037906104 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to bthalassemia
    • Galanello R, Piga A, Alberti D, et al. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to bthalassemia. J Clin Pharmacol. 2003;43(6):565-572.
    • (2003) J Clin Pharmacol , vol.43 , Issue.6 , pp. 565-572
    • Galanello, R.1    Piga, A.2    Alberti, D.3
  • 14
    • 27744485989 scopus 로고    scopus 로고
    • Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease. the role of natural and synthetic chelators
    • Kontoghiorghes GJ, Kolnagou A. Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease. The role of natural and synthetic chelators. Curr Med Chem. 2005;12(23):2695-2709.
    • (2005) Curr Med Chem , vol.12 , Issue.23 , pp. 2695-2709
    • Kontoghiorghes, G.J.1    Kolnagou, A.2
  • 15
    • 0024337363 scopus 로고
    • Survival and causes of death in thalassaemia major
    • Zurlo MG, De Stefano P, Borgna-Pignatti C, et al. Survival and causes of death in thalassaemia major. Lancet. 1989;ii(8653):27-29.
    • (1989) Lancet , vol.2 , Issue.8653 , pp. 27-29
    • Zurlo, M.G.1    De Stefano, P.2    Borgna-Pignatti, C.3
  • 16
    • 33748807736 scopus 로고    scopus 로고
    • Survival of medically treated thalassaemia patients in Cyprus Trends and risk factors over the period 1980-2004
    • Tefler P, Goen PG, Christou S, et al. Survival of medically treated thalassaemia patients in Cyprus. Trends and risk factors over the period 1980-2004. Haematologica. 2006;91(9): 1187-1192.
    • (2006) Haematologica , vol.91 , Issue.9 , pp. 1187-1192
    • Tefler, P.1    Goen, P.G.2    Christou, S.3
  • 17
    • 0023489829 scopus 로고
    • Effective chelation of iron in b-thalassaemia with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ, Aldouri MA, Hoffbrand AV, et al. Effective chelation of iron in b-thalassaemia with the oral iron chelator 1,2-dimethyl-3- hydroxypyrid-4-one. Br Med J. 1987;295(6612):1509-1512.
    • (1987) Br Med J , vol.295 , Issue.6612 , pp. 1509-1512
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Hoffbrand, A.V.3
  • 18
    • 43449093775 scopus 로고    scopus 로고
    • Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders
    • Angelucci E, Barosi G, Camaschella C, et al. Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica. 2008;93(5):741-752.
    • (2008) Haematologica , vol.93 , Issue.5 , pp. 741-752
    • Angelucci, E.1    Barosi, G.2    Camaschella, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.