HPLC/DAD assay of related impurity ethyl-4-oxopiperidine-1-carboxylate in loratadine through derivatization with 2,4-dinitrophenylhydrazine

Journal of Liquid Chromatography and Related Technologies

Volumn 32, Issue 17, 2009, Pages 2569-2583

  Albu, Monica ^a   David, Victor ^b   Tache, Florentin ^a,b   Medvedovici, Andrei ^a,b  

^a LaborMed Pharma SA   (Romania)

^b UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

2,4 Dinitrophenylhydrazine; Ethyl 4 oxopiperidine 1 carboxylate; HPLC DAD; Loratadine; Precolumn derivatization; Related impurities; Validation

Indexed keywords

2,4-DINITROPHENYLHYDRAZINE; ETHYL-4-OXOPIPERIDINE-1-CARBOXYLATE; HPLC/DAD; LORATADINE; PRECOLUMN DERIVATIZATION; RELATED IMPURITIES; VALIDATION;

BYPRODUCTS; CARBOXYLATION; DRUG PRODUCTS; IONIZATION OF GASES; REACTION KINETICS;

IMPURITIES;

2,4 DINITROPHENYLHYDRAZINE; CARBOXYLIC ACID; ETHYL 4 OXOPIPERIDINE 1 CARBOXYLATE; LORATADINE; UNCLASSIFIED DRUG;

ANTENNA; ARTICLE; DERIVATIZATION; DRUG FORMULATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN;

EID: 70350635193     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070903249757     Document Type: Article

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