Degradation product of loratadine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 3, 2007, Pages 1191-1192

  Gibbons, John ^a   Sardella, Dan ^a   Duncan, David ^a   Pike, Richard ^a  

^a Genpharm Inc   (Canada)

Author keywords

Alkaline hydrolysis; Degradation product; Ester cleavage; Loratadine

Indexed keywords

CARBAMIC ACID; DESLORATADINE; LORATADINE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DECARBOXYLATION; DRUG DEGRADATION; DRUG DETERMINATION; DRUG STRUCTURE; HYDROLYSIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 33846575169     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.10.030     Document Type: Note

References (3)

1. Wade Jr. L.G. Organic Chemistry. fifth ed. (2003), Prentice Hall, New Jersey p. 990
2. Smith M.B., and March J. March's Advanced Organic Chemistry: Reactions, Mechanisms and Structure. fifth ed. (2001), Wiley & Sons, New York p. 474
3. Johnson S.L., and Morrison D.L. J. Am. Chem. Soc. 94 (1972) 1323-1334