Editorial: Possible hidden hazards of mass vaccination against new influenza A/H1N1: Have the cardiovascular risks been adequately weighed?

Medical Microbiology and Immunology

Volumn 198, Issue 4, 2009, Pages 205-209

  Bhakdi, Sucharit ^a   Lackner, Karl ^a   Doerr, Hans Wilhelm ^b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AS 03; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINYLALANYL DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; POLYSORBATE 80; UNCLASSIFIED DRUG; WATER OIL CREAM;

ADAPTIVE IMMUNITY; ATHEROGENESIS; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DISEASE EXACERBATION; DRUG FEVER; DRUG SAFETY; EDITORIAL; HEALTH CARE PLANNING; HEALTH PROGRAM; HEART INFARCTION; HUMAN; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VIRUS A H1N1; INJECTION SITE PAIN; INNATE IMMUNITY; MASS IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; UNITED STATES; CARDIOVASCULAR DISEASE; EUROPE; IMMUNOLOGY;

CARDIOVASCULAR DISEASES; EUROPE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MASS VACCINATION; RISK ASSESSMENT;

EID: 70350614296     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-009-0130-9     Document Type: Editorial

References (28)

1. Chan M (2009) World now at the start of 2009 influenza pandemic: http:/ www.who.int/mediacentre/news/statements/2009/h1n1-pandemic-phase6-20090611/en/ index.html. Statement to the press by WHO Director General Dr Margaret Chan; WHO, 11. Juni 2009
2. WHO (2009) WHO pandemic phase description and main actions by phase. http://www.who.int/csr/disease/influenza/GIPA3AideMemoire.pdf
3. CDC CfDCaP (2009) 2009 H1N1 Flu: international situation update. http://www.cdc.gov/h1n1flu/updates/international/
4. ACIP (2009) Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep 58:1-8 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=19713882
5. Neuzil KM (2009) Pandemic influenza vaccine policy-considering the early evidence. N Engl J Med http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt=Citation&list-uids=19745213
6. Reed S (2009) Brief overview of use of oil-in-water emulsions as adjuvants for influenza vaccines. http:/ www.who.int/vaccine-research/documents/ Brief-overview-of-use-of-oil-in-water-emulsions.pdf
7. Clark TW, Pareek M, Hoschler K, Dillon H, Nicholson KG, Groth N, Stephenson I (2009) Trial of influenza A (H1N1) 2009 monovalent MF59-adjuvanted vaccine-preliminary report. N Engl J Med http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list-uids=19745215
8. A Seubert E Monaci M Pizza DT O'Hagan A Wack 2008 The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells J Immunol 180 5402 5412 1:CAS:528:DC%2BD1cXkt1arsbc%3D 18390722
9. I Leroux-Roels A Borkowski T Vanwolleghem M Drame F Clement E Hons JM Devaster G Leroux-Roels 2007 Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial Lancet 370 580 589 10.1016/S0140-6736(07)61297-5 1:CAS:528: DC%2BD2sXpt1ShtL4%3D 17707753 (Pubitemid 47247854)
10. Lehr HA, Sagban TA, Ihling C, Zahringer U, Hungerer KD, Blumrich M, Reifenberg K, Bhakdi S (2001) Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation 104:914-920 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=&db= PubMed&dopt=Citation&list-uids=11514379
11. S Bhakdi KJ Lackner SR Han M Torzewski M Husmann 2004 Beyond cholesterol: the enigma of atherosclerosis revisited Thromb Haemost 91 639 645 1:CAS:528:DC%2BD2cXjsVGrsrg%3D 15045123 (Pubitemid 38477443)
12. S Kiechl E Lorenz M Reindl CJ Wiedermann F Oberhollenzer E Bonora J Willeit DA Schwartz 2002 Toll-like receptor 4 polymorphisms and atherogenesis N Engl J Med 347 185 192 10.1056/NEJMoa012673 1:CAS:528:DC%2BD38Xlt12jsLo%3D 12124407 (Pubitemid 34764822)
13. K Herold B Moser Y Chen S Zeng SF Yan R Ramasamy J Emond R Clynes AM Schmidt 2007 Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress J Leukoc Biol 82 204 212 10.1189/jlb.1206751 1:CAS:528:DC%2BD2sXos12rtb4%3D 17513693 (Pubitemid 47230628)
14. C Bopp A Bierhaus S Hofer A Bouchon PP Nawroth E Martin MA Weigand 2008 Bench-to-bedside review: the inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis Crit Care 12 201 10.1186/cc6164 18226173
15. A Soro-Paavonen AM Watson J Li K Paavonen A Koitka AC Calkin D Barit MT Coughlan BG Drew GI Lancaster M Thomas JM Forbes PP Nawroth A Bierhaus ME Cooper KA Jandeleit-Dahm 2008 Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes Diabetes 57 2461 2469 10.2337/db07-1808 1:CAS:528:DC%2BD1cXhtFSrtrnP 18511846
16. Pellegrini M, Nicolay U, Lindert K, Groth N, Della Cioppa G (2009) MF59-adjuvanted versus non-adjuvanted influenza vaccines: Integrated analysis from a large safety database. Vaccine [Epup ahead of print] http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt= Citation&list-uids=19751689
17. WHO (2003) Update: cardiac-related events during the civilian smallpox vaccination program-United States, 2003. MMWR Morb Mortal Wkly Rep 52:492-496 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&dopt=Citation&list-uids=12809110
18. WHO (2003) Cardiac deaths after a mass smallpox vaccination campaign-New York City, 1947. MMWR Morb Mortal Wkly Rep 52:933-936
19. J Cinatl Jr M Michaelis HW Doerr 2007 The threat of avian influenza A (H5N1). Part I: epidemiologic concerns and virulence determinants Med Microbiol Immunol 196 181 190 10.1007/s00430-007-0042-5 17492465 (Pubitemid 350105921)
20. J Cinatl Jr M Michaelis HW Doerr 2007 The threat of avian influenza A (H5N1). Part IV: development of vaccines Med Microbiol Immunol 196 213 225 10.1007/s00430-007-0052-3 1:CAS:528:DC%2BD2sXptVGmsL4%3D 17541633 (Pubitemid 350105929)
21. M Michaelis HW Doerr J Cinatl Jr 2009 Novel swine-origin influenza A virus in humans: another pandemic knocking at the door Med Microbiol Immunol 198 175 183 10.1007/s00430-009-0118-5 19543913
22. A Ortqvist F Granath J Askling J Hedlund 2007 Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area Eur Respir J 30 414 422 10.1183/09031936.00135306 1:STN:280: DC%2BD2srhtlCltg%3D%3D 17537767 (Pubitemid 351182062)
23. PA Gross AW Hermogenes HS Sacks J Lau RA Levandowski 1995 The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature Ann Intern Med 123 518 527 1:STN:280:DyaK2MzptVGruw%3D%3D 7661497
24. T Jefferson D Rivetti A Rivetti M Rudin C Di Pietrantonj V Demicheli 2005 Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review Lancet 366 1165 1174 10.1016/S0140-6736(05)67339-4 1:STN:280:DC%2BD2MrisFWisQ%3D%3D 16198765 (Pubitemid 41393594)
25. T Vu S Farish M Jenkins H Kelly 2002 A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community Vaccine 20 1831 1836 10.1016/S0264-410X(02)00041-5 11906772 (Pubitemid 34242840)
26. AG Jansen EA Sanders KL Nichol AM van Loon AW Hoes E Hak 2008 Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program Vaccine 26 5567 5574 10.1016/j.vaccine.2008. 08.003 18722492
27. J Puig-Barbera J Diez-Domingo AB Varea GS Chavarri JA Rodrigo SP Hoyos DG Vidal 2007 Effectiveness of MF59-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly Vaccine 25 7313 7321 10.1016/j.vaccine.2007.08.039 1:CAS:528:DC%2BD2sXhtFWhu7zI 17889411
28. C Warren-Gash L Smeeth AC Hayward 2009 Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review Lancet Infect Dis 9 601 610 10.1016/S1473-3099(09)70233-6 19778762