Biomonitoring of the di(2-ethylhexyl) phthalate metabolites mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate in children and adults during the course of time and seasons

International Journal of Hygiene and Environmental Health

Volumn 212, Issue 6, 2009, Pages 679-684

  Hildenbrand, Sibylle ^a   Wodarz, Roman ^a   Gabrio, Thomas ^b   Volland, Gerhard ^c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Baden Wuerttemberg State Health Office   (Germany)

^c UNIVERSITY OF STUTTGART   (Germany)

Author keywords

5 OH MEHP; 5 oxo MEHP; Biomonitoring; DEHP; Phthalates; Seasonal effects

Indexed keywords

MONO(2 ETHYL 5 HYDROXYHEXYL) PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL)PHTHALATE; MONO(2-ETHYL-5-HYDROXYHEXYL) PHTHALATE; MONO(2-ETHYL-5-OXOHEXYL)PHTHALATE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; CHILD; ENVIRONMENTAL MONITORING; FEMALE; HUMAN; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED; POLLUTANT; PRESCHOOL CHILD; SEASON; URINE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; PHTHALIC ACIDS; SEASONS;

EID: 70350607831     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2009.06.003     Document Type: Article

References (19)

1. Becker K., Seiwert M., Angerer J., Heger W., Koch H.M., Nagorka R., Roßkamp E., Schlüter C., Seifert B., and Ullrich D. DEHP metabolites in urine of children and DEHP in house dust. Int. J. Hyg. Environ. Health 20 (2004) 409-417
2. Doull J., Cattley R., Elcombe C., Lake B.G., Swenberg J., Wilkinson C., Williams G., and van Gemert M. A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new US EPA Risk Assessment Guidelines. Regul. Toxicol. Pharmacol. 29 (1999) 327-357
3. ECB European Chemicals Bureau, 2004. Risk assessment report for Bis(2-ethylhexyl) phthalate (consolidated final report: February 2004). Doc. No. R042_0402_env_hh_4-6.
4. Frederiksen H., Skakkebaek N.E., and Andersson A.M. Metabolism of phthalates in humans. Mol. Nutr. Food Res. 51 (2007) 899-911
5. Fromme H., Bolte G., Koch H.M., Angerer J., Boehmer S., Drexler H., Mayer R., and Liebl B. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int. J. Hyg. Environ. Health 210 (2007) 21-33
6. Hauser R., Meeker J.D., Park S., Silva M.J., and Calafat A.M. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ. Health Perspect. 112 (2004) 1734-1740
7. Hauser R., Meeker J.D., Singh N.P., Silva M.J., Ryan L., Duty S., and Calafat A.M. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum. Reprod. 22 (2007) 688-695
8. Hoppin J.A., Brock J.W., Davis B.J., and Baird D.D. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ. Health Perspect. 110 (2002) 515-518
9. Koch H.M., Rossbach B., Drexler H., and Angerer J. Internal exposure of the general population to DEHP and other phthalates - determination of secondary and primary phthalate monoester metabolites in urine. Environ. Res. 93 (2003) 177-185
10. Koch H.M., Bolt H.M., and Angerer J. Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after single oral dose of deuterium-labelled DEHP. Arch. Toxicol. 78 (2004) 123-130
11. Kommission Human-Biomonitoring. Stoffmonographie di(2-ethylhexyl)phthalat (DEHP) - Referenzwerte für 5oxo-MEHP und 5OH-MEHP im Urin. Bundesgesundheitsbl. - Gesundheitsforsch Gesundheitsforsch. - Gesundheitsschutz 48 (2005) 706-722
12. Kommission Human-Biomonitoring. Ableitung von Human-Biomonitoring-(HBM-)Werten auf der Basis tolerabler Aufnahmemengen - Teil III: HBM-Werte für Di(2-ethylhexyl)phthalat (DEHP). Bundesgesundheitsbl. - Gesundheitsforsch Gesundheitsforsch. - Gesundheitsschutz 50 (2007) 255-259
13. Mettang T., Thomas S., Kiefer T., Fischer F.P., Kuhlmann U., Wodarz R., and Rettenmeier A.W. Uraemic pruritus and exposure to di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrol. Dial. Transplant. 11 (1996) 2439-2443
14. Mettang T., Alscher D.M., Pauli-Magnus C., Dunst R., Kuhlmann U., and Rettenmeier A.W. Phthalic acid is the main metabolite of the plasticizer di(2-ethylhexyl) phthalate in peritoneal dialysis patients. Adv. Perit. Dial. 15 (1999) 229-232
15. Nuti F., Hildenbrand S., Chelli M., Wodarz R., and Papini A.M. Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters. Bioorg. Med. Chem. 13 (2005) 3461-3465
16. Sharman M., Read W.A., Castle L., and Gilbert J. Levels of di-(2-ethylhexyl)phthalate and total phthalate esters in milk, cream, butter and cheese. Food Addit. Contam. 11 (1994) 375-385
17. Silva M.J., Barr D.B., Reidy J.A., Malek N.A., Hodge C.C., Caudill S.P., Brock J.W., Needham L.L., and Calafat A.M. Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ. Health Perspect. 112 (2004) 331-338
18. Wams T.J. Diethylhexylphthalate as an environmental contaminant - a review. Sci. Total Environ. 66 (1987) 1-16
19. Wittassek M., Heger W., Koch H.M., Becker K., Angerer J., and Kolossa-Gehring M. Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children - a comparison of two estimation models based on urinary DEHP metabolite levels. Int. J. Hyg. Environ. Health 210 (2007) 35-42