Experimental study of the preparation of targeted microbubble contrast agents carrying urokinase and RGDS

Ultrasonics

Volumn 49, Issue 8, 2009, Pages 676-681

  Mu, Yuming ^a   Li, Ling ^a   Ayoufu, Guligena ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Clot lysis; Direct conjugation; RGDS; Targeted contrast agent; Urokinase

Indexed keywords

CLOT LYSIS; DIRECT CONJUGATION; RGDS; TARGETED CONTRAST AGENT; UROKINASE;

FLOW CYTOMETRY;

EXPERIMENTS;

ARGINYL GLYCYL ASPARTYL SERINE; ARGINYL-GLYCYL-ASPARTYL-SERINE; CONTRAST MEDIUM; DRUG CARRIER; FIBRINOLYTIC AGENT; OLIGOPEPTIDE; UROKINASE;

ANIMAL; ARTICLE; CHEMISTRY; METHODOLOGY; MICROBUBBLE; PATHOLOGY; RABBIT; RADIATION EXPOSURE; THROMBOSIS; TREATMENT OUTCOME; ULTRASOUND;

ANIMALS; CONTRAST MEDIA; DRUG CARRIERS; FIBRINOLYTIC AGENTS; MICROBUBBLES; OLIGOPEPTIDES; RABBITS; SONICATION; THROMBOSIS; TREATMENT OUTCOME; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 70350590925     PISSN: 0041624X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultras.2009.05.003     Document Type: Article

References (13)

1. Schumann P.A., Christiansen J.P., Quigley R., et al. Targeted-microbubble binding selectively to GPIIb/IIIa receptors of platelet thrombi. Invest. Radiol. 37 (2002) 587-593
2. Atar S., Luo H., Nagai T., et al. Ultrasonic thrombolysis: catheter-delivered and transcutaneous applications. Euro. J. Ultrasound 9 (1999) 39-54
3. Culp W.C., Porter T.R., McCowan, et al. Microbubble - augmented ultrasound declotting of thrombosed arteriovenous dialysis grafts in dogs. J. Vasc. Interv. Radiol. 14 (2003) 343-347
4. Unger E.C., Hersh E., Vannan M., et al. Local drug and gene delivery through microbubbles. J. Prog. Cardiovasc. Dis. 44 1 (2001) 45-54
5. Klibanov A.L., Hughes M.S., Devine D.V., et al. Targeter delivery of gas-filled microspheres, contrast agent four ultrasound imaging. J. Drug. Deliv. Rev. 37 3 (1999) 139-157
6. Tiukinhoy-Laing S.D., Huang S., Klegerman M., et al. Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes. Thromb. Res. 119 6 (2007) 777-784
7. Unger E.C., Mc Creery T.P., Sweitzer R.H., et al. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest. Radiol. 33 12 (1998) 886-892
8. Wang X.T., Li S., Zhang X.B., et al. Preparation of thrombus-targeted urokinase liposomes and its thrombolytic effect in model rats. Yao Xue Xue Bao 38 3 (2003) 231-235
9. Schneider M. Characteristics of SonoVue. Echocardiography 16 (1999) 743-746
10. Birnbaum Y., Atar S., Luo H., et al. Ultrasound has synergistic effects in vitro with tirofiban and heparin for thrombus dissolution. Thromb. Res. 96 6 (1999) 451-458
11. Wang X., and Xu L. An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research. Thromb. Res. 115 (2005) 95-100
12. Schutt E.G., Klein D.H., Robert M., et al. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. J. Angew. Chem. Int. Ed. 42 (2003) 3218-3235
13. Hasik M.J., Kim D.H., Howle L.E., et al. Evaluation of synthetic phospholipid ultrasound contrast agents. J. Ultrason. 40 4 (2002) 973-998