D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - A randomized, placebo controlled double blind study

Phytomedicine

Volumn 16, Issue 12, 2009, Pages 1077-1082

  Werner, Natalie S ^a   Duschek, Stefan ^a   Schandry, Rainer ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Blood pressure; Camphor; Cognitive function; Crataegus berry; Elderly women; Placebo controlled double blind study; Randomized

Indexed keywords

CAMPHOR; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BRAIN METABOLISM; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FEMALE; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

AGED; ANALYSIS OF VARIANCE; BLOOD PRESSURE; CAMPHOR; COGNITION; CRATAEGUS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FRUIT; HUMANS; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS;

CRATAEGUS; DRYOBALANOPS;

EID: 70350580521     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.05.006     Document Type: Article

References (20)

1. Belz G.G., Butzer R., Gaus W., and Loew D. Camphor Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine 9 (2002) 581
2. Belz G.G., and Loew D. Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components. Phytomedicine 10 Suppl. IV (2003) 61
3. Cahill L., and Alkire M.T. Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding. Neurobiol. Learn. Mem. 79 (2003) 194-198
4. Cahill L., Prins B., Weber M., and McGaugh J.L. Beta-adrenergic activation and memory for emotional events. Nature 371 (1994) 702-704
5. Chmura J., Nazar K., and Kaciuba-Uscilko H. Choice reaction time during graded exercise in relation to blood lactate and plasma catecholamine thresholds. Int. J. Sports Med. 15 (1994) 172-176
6. Cohen M.R. Unlabeled cubes spell trouble: camphor concerns. Nursing 38 (2008) 17
7. Duschek S., Hadjamu M., and Schandry R. Dissociation between cortical activation and cognitive performance in the pharmacological treatment of chronic hypotension. Biol. Psychol. 75 (2007) 277-285
8. Duschek S., Hadjamu M., and Schandry R. Enhancement of cerebral blood flow and cognitive performance due to pharmacological blood pressure elevation in chronic hypotension. Psychophysiology 44 (2007) 145-153
9. Hempel B., Kroll M., and Schneider B. Efficacy and safety of a herbal drug containing hawthorn beries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study. Arzneimittelforschung 55 (2005) 443-450
10. Herrmann V., Butzer R., Roll S., Malerczyk C., and Belz G.G. Hemodynamic responses to a cumulative dosage of Korodin Herz-Kreislauf-Tropfen. Eur. J. Clin. Pharmacol. 50 (1996) 544
11. Kroll M., Ring C., Gaus W., and Hempel B. A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension. Phytomedicine 12 (2005) 395-402
12. Oswald W.D., and Roth E. Der Zahlen-Symbol-Test (1987), Hogrefe, Göttingen
13. Pardo J.V., Fox P.T., and Raichle M.E. Localisation of a human system for sustained attention by positron emission tomography. Nature 349 (1991) 61-64
14. Paus T., Zatorre R.J., Hofle N., Caramanos Z., Gorman J., Petrides M., and Evans A.C. Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task. J. Cogn. Neurosci. 9 (1997) 392-408
15. Peyrin L., Pequignot J.M., Lacour J.R., and Fourcade J. Relationship between catecholamine or 3-methoxy 4-hydroxy phenylglycol changes and the mental performance under submaximal exercise in man. Psychopharmacology 93 (1987) 188-192
16. Posner M.I., and Petersen S.E. The attention system of the human brain. Annu. Rev. Neurosci. 13 (1990) 25-42
17. Reitan R.M. Validity of the trail making test as an indication of organic brain damage. Percept. Mot. Skills 8 (1958) 271-278
18. Schandry R., and Duschek S. The effect of Camphor-Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension - A randomized placebo controlled double blind design. Phytomedicine 15 (2008) 914-922
19. Wechsler D. Wechsler Intelligence Scale for Adults - Revised (1981), Psychological Corporation, San Antonio, TX
20. Yagi Y., Coburn K.L., Estes K.M., and Arruda J.E. Effects of aerobic exercise and gender on visual and auditory P300, reaction time, and accuracy. Eur. J. Appl. Physiol. 80 (1999) 402-408