Autism and Nonsyndromic Mental Retardation Associated with a De Novo Mutation in the NLGN4X Gene Promoter Causing an Increased Expression Level

Biological Psychiatry

Volumn 66, Issue 10, 2009, Pages 906-910

  Daoud, Hussein ^a,b   Bonnet Brilhault, Frédérique ^a,b,c   Védrine, Sylviane ^a,b   Demattéi, Marie Véronique ^b,d   Vourc'h, Patrick ^a,b,c   Bayou, Nadia ^f   Andres, Christian R ^a,b,c   Barthélémy, Catherine ^a,b,c   Laumonnier, Frédéric ^a,b   Briault, Sylvain ^a,b,e  

^a INSERM   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c UNIVERSITY HOSPITAL OF TOURS   (France)

^d CNRS   (France)

^e Centre Hospitalier Regional   (France)

^f CHARLES NICOLLE HOSPITAL   (Tunisia)

Author keywords

Autism; mental retardation; NLGN4X; overexpression; regulatory sequences

Indexed keywords

LUCIFERASE; NEUROLIGIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X LINKED NEUROLIGIN 4 GENE;

3' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ARTICLE; AUTISM; BASE PAIRING; CHILD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; SCHOOL CHILD; SEX DIFFERENCE;

AUTISTIC DISORDER; CARRIER PROTEINS; CHILD; DNA MUTATIONAL ANALYSIS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MEMBRANE PROTEINS; MENTAL DISORDERS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 70350571767     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.05.008     Document Type: Article

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