Influence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functions

Fertility and Sterility

Volumn 92, Issue 5, 2009, Pages 1780-1782

  Nasr, Ahmed ^a   Nafeh, Hanan ^b  

^a Women's Health University Center   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CIMICIFUGA RACEMOSA EXTRACT; GAMMA GLUTAMYLTRANSFERASE; PROTHROMBIN; SERUM ALBUMIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CIMICIFUGA RACEMOSA; CLINICAL TRIAL; COLOR ULTRASOUND FLOWMETRY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HOT FLUSH; HUMAN; LIVER BLOOD FLOW; LIVER FUNCTION; LIVER PERFUSION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; TREATMENT DURATION; VASOMOTOR DISORDER;

CIMICIFUGA; DRUG-INDUCED LIVER INJURY; FEMALE; FOLLOW-UP STUDIES; HOT FLASHES; HUMANS; LIVER; LIVER CIRCULATION; MIDDLE AGED; PLANT EXTRACTS; POSTMENOPAUSE; PREVALENCE; ULTRASONOGRAPHY, DOPPLER, COLOR; VASOMOTOR SYSTEM;

EID: 70350567794     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.05.038     Document Type: Article

References (21)

1. Heinemann K., Rübig A., Strothmann A., Nahum G.G., and Heinemann L.A. Prevalence and opinions of hormone therapy prior to the Women's Health Initiative: a multinational survey on four continents. J Womens Health (Larchmt) 17 (2008) 1151-1166
2. van de Weijer P.H. Risks of hormone therapy in the 50-59 year age group. Maturitas 60 (2008) 59-64
3. Clemons M., and Goss P. Estrogen and the risk of breast cancer. N Engl J Med 344 (2001) 276-285
4. Huntley A., and Ernst E. A systematic review of the safety of black cohosh. Menopause 10 (2003) 58-64
5. Nappi R.E., Malavasi B., Brundu B., and Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 20 (2005) 30-35
6. Chow E.C., Teo M., Ring J.A., and Chen J.W. Liver failure associated with the use of black cohosh for menopausal symptoms. Med J Aust 188 (2008) 420-422
7. Joy D., Joy J., and Duane P. Black cohosh: a cause of abnormal postmenopausal liver function tests. Climacteric 11 (2008) 84-88
8. Mahady G.B., Low Dog T., Barrett M.L., Chavez M.L., Gardiner P., Ko R., et al. United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity. Menopause 15 (2008) 628-638
9. Firenzuoli F, Goril L, di Sarsina PR. Black cohosh hepatic safety: follow-up of 107 patients consuming a special cimicifuga racemosa rhizome herbal extract and review of literature. Evid Based Complement Alternat Med. In press.
10. Partiquin H., Lafortune M., Burns P.N., and Dauzat M. Duplex Doppler examination in portal hypertension: technique and anatomy. AJR Am J Roentgenol 149 (1987) 71-76
11. Moriyasu F., Ban N., Nishida O., Nakamura T., Miyake T., Uchino H., et al. Clinical application on an ultrasonic duplex system in the quantitative measurement of portal blood flow. J Clin Ultrasound 14 (1986) 579-588
12. In: Quick A.J. (Ed). Haemorrhagic diseases and thrombosis (1966), Lee and Febiger, Philadelphia
13. Geller S.E., and Studee L. Contemporary alternatives to plant estrogens for menopause. Maturitas 55 Suppl 1 (2006) S3-S13
14. In: Blumenthal M. (Ed). Cohosh, the ABC clinical guide to herbs (2002), American Botanical Council, Austin, TX
15. Pepping J. Black cohosh: Cimicifuga racemosa. Am Journal Health Syst Pharm 56 (1999) 1400-1402
16. Whiting P.W., Clouston A., and Kerlin P. Black cohosh and other herbal remedies associated with acute hepatitis. Med J Aust 177 (2002) 440-443
17. Lontos S., Jones R.M., Angus P.W., and Gow P.J. Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 179 (2003) 390-391
18. Cohen S.M., O'Connor A.M., Hart J., Merel N.H., and Te H.S. Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause 11 (2004) 575-577
19. National Institutes of Health. Workshop on the safety of black cohosh in clinical studies (2004), National Center for Complementary and Alternative Medicine, National Institutes of Health Office of Dietary Supplements, Washington, DC
20. Mazzanti G, Di Sotto A, Franchitto A, Mastrangelo S, Pezzella M, Vitalone A, et al. Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices. Phytomedicine. In press.
21. Lude S., Torok M., Dieterle S., Knapp A.C., Kaeufeler R., Jaggi R., et al. Hepatic effects of Cimicifuga racemosa extract in vivo and in vitro. Cell Mol Life Sci 64 (2007) 2848-2857