-
1
-
-
67649538485
-
-
Panel on Antiretroviral Guidelines for Adults and Adolescents. Department of Health and Human Services. 3 November
-
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. 3 November 2008. pp. 1-139. http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
-
(2008)
Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
, pp. 1-139
-
-
-
3
-
-
11244292470
-
Pharmacokinetics and safety of tipranavir/ritonavir alone or in combination with saquinavir amprenavir or lopinavir: Interim analysis of BI1182.51
-
[abstract 5.1] April Rome
-
Leith J, Walmsley S, Katlama C, et al. Pharmacokinetics and safety of tipranavir/ritonavir alone or in combination with saquinavir, amprenavir or lopinavir: interim analysis of BI1182.51 [abstract 5.1]. 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 2004; Rome.
-
(2004)
5th International Workshop on Clinical Pharmacology of HIV Therapy
-
-
Leith, J.1
Walmsley, S.2
Katlama, C.3
-
4
-
-
40549127134
-
Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
-
Abel S, Russell D, Taylor-Worth RJ, et al. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008; 65 (Suppl 1):27-37.
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 27-37
-
-
Abel, S.1
Russell, D.2
Taylor-Worth, R.J.3
-
5
-
-
66949126977
-
Effect of tipranavir + ritonavir on pharmacokinetics of raltegravir
-
Hanley WD, Wenning LA, Moreau A, et al. Effect of tipranavir + ritonavir on pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2009; 53: 2752-2755.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 2752-2755
-
-
Hanley, W.D.1
Wenning, L.A.2
Moreau, A.3
-
6
-
-
33748893949
-
Unexpected drug- drug interaction between tipranavir/ritonavir and enfuvirtide
-
González de
-
González de Requena D, Calcagno A, Bonora S, et al. Unexpected drug- drug interaction between tipranavir/ritonavir and enfuvirtide. AIDS 2006; 20:1977-1979.
-
(2006)
AIDS
, vol.20
, pp. 1977-1979
-
-
Requena, D.1
Calcagno, A.2
Bonora, S.3
-
7
-
-
34548321373
-
Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: Sub-analysis from RESIST
-
Raffi F, Battegay M, Rusconi S, et al. Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST. AIDS 2007; 21:1977-1980.
-
(2007)
AIDS
, vol.21
, pp. 1977-1980
-
-
Raffi, F.1
Battegay, M.2
Rusconi, S.3
-
9
-
-
33746576313
-
Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimenof antiretroviral drugsfor treatment-experiencedHIV-1- infectedpatients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multidrug resistant patients with Tipranavir (RESIST)studies: Ananalysis ofcombineddata from two randomised open-label trials
-
RESIST investigator group
-
Hicks CB, Cahn P, Cooper DA, et al., RESIST investigator group. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimenof antiretroviral drugsfor treatment-experiencedHIV-1-infectedpatients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multidrug resistant patients with Tipranavir (RESIST)studies: ananalysis ofcombineddata from two randomised open-label trials. Lancet 2006; 368:466-475.
-
(2006)
Lancet
, vol.368
, pp. 466-475
-
-
Hicks, C.B.1
Cahn, P.2
Cooper, D.A.3
-
11
-
-
70350551292
-
-
Boehringer Ingelheim. US prescribing information [online] [Accessed 9 June 2009]
-
Boehringer Ingelheim. Aptivus1 (tipranavir) capsules, 250 mg. US prescribing information [online]. http://bidocs.boehringer-ingelheim.com/ BIWebAccess/ ViewServlet.ser?docBase=renetnt&folderPath=/ Prescribing+Information/ PIs/Aptivus/10003515+US+01.pdf [Accessed 9 June 2009]
-
Aptivus1 (Tipranavir) Capsules 250 Mg
-
-
-
12
-
-
53349128051
-
Drug toxicity HIV progression or comorbidity of aging: Does tipranavir use increase the risk of intracranial hemorrhage?
-
Veterans Aging Cohort Study Project Team.
-
Justice AC, Zingmond DS, Gordon KS, et al., Veterans Aging Cohort Study Project Team. Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage? Clin Infect Dis 2008; 47:1226-1230.
-
(2008)
Clin Infect Dis
, vol.47
, pp. 1226-1230
-
-
Justice, A.C.1
Zingmond, D.S.2
Gordon, K.S.3
-
13
-
-
33747017561
-
RESIST-1 (R-1) and RESIST-2 (R-2) 48 week meta-analyses demonstrate superiority of protease inhibitor (PI) tipranavir + ritonavir (TPV/r) over an optimized comparator PI (CPI/r) regimen in antiretroviral (ARV) experienced patients
-
for the RESIST-2 and RESIST-1 Study Teams et al. Dublin abstract PS3/8
-
Cahn P, Hicks C, for the RESIST-2 and RESIST-1 Study Teams, et al. RESIST-1 (R-1) and RESIST-2 (R-2) 48 week meta-analyses demonstrate superiority of protease inhibitor (PI) tipranavir + ritonavir (TPV/r) over an optimized comparator PI (CPI/r) regimen in antiretroviral (ARV) experienced patients. Tenth European AIDS Conference/European AIDS Clinical Society; Dublin; abstract PS3/8, 2005.
-
(2005)
Tenth European AIDS Conference/European AIDS Clinical Society
-
-
Cahn, P.1
Hicks, C.2
-
14
-
-
33750338185
-
Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir
-
Baxter JD, Schapiro JM, Boucher CAB, et al. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol 2006; 80:10794-10801.
-
(2006)
J Virol
, vol.80
, pp. 10794-10801
-
-
Baxter, J.D.1
Schapiro, J.M.2
Boucher, C.A.B.3
-
15
-
-
50949126474
-
Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients
-
Marcelin AG, Masquelier B, Descamps D, et al. Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients. Antimicrob Agents Chemother 2008; 52:3237-3243.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3237-3243
-
-
Marcelin, A.G.1
Masquelier, B.2
Descamps, D.3
-
16
-
-
37049036372
-
Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier
-
Dierynck I, De Wit M, Gustin E, et al. Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier. J Virol 2007; 81:13845-13851.
-
(2007)
J Virol
, vol.81
, pp. 13845-13851
-
-
Dierynck, I.1
De Wit, M.2
Gustin, E.3
-
17
-
-
46049096485
-
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
-
Shen L, Peterson S, Sedaghat AR, et al. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nat Med 2008; 14:762-766.
-
(2008)
Nat Med
, vol.14
, pp. 762-766
-
-
Shen, L.1
Peterson, S.2
Sedaghat, A.R.3
-
19
-
-
34548262047
-
An open randomized 2-way crossover study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects
-
[abstract no. 55 plus poster] 16-18 April Budapest
-
Abel S, RidgwayC, Hamlin J, et al. An open, randomized, 2-way crossover study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects [abstract no. 55 plus poster]. 8th InternationalWorkshop on Clinical Pharmacology of HIV Therapy; 16-18 April 2007; Budapest.
-
(2007)
8th InternationalWorkshop on Clinical Pharmacology of HIV Therapy
-
-
Abel, S.1
Ridgway, C.2
Hamlin, J.3
-
21
-
-
34547780413
-
Pharmacokinetics of darunavir/ritonavir and TMC125 alone and coadministered in HIV-negative volunteers
-
Scholler-Gyure M, Kakuda TN, Sekar V, et al. Pharmacokinetics of darunavir/ ritonavir and TMC125 alone and coadministered in HIV-negative volunteers. Antivir Ther 2007; 12:789-796. (Pubitemid 47235493)
-
(2007)
Antiviral Therapy
, vol.12
, Issue.5
, pp. 789-796
-
-
Scholler-Gyure, M.1
Kakuda, T.N.2
Sekar, V.3
Woodfall, B.4
De Smedt, G.5
Lefebvre, E.6
Peeters, M.7
Hoetelmans, R.M.8
-
22
-
-
33746833432
-
Absence of an interaction between the potent HIV protease inhibitor TMC114 and the fusion inhibitor enfuvirtide in the POWER 3 analysis
-
[abstract no. P54 plus poster] 20-22 April Lisbon
-
Sekar V, De Paepe E, Vangeneugden T, et al. Absence of an interaction between the potent HIV protease inhibitor TMC114 and the fusion inhibitor enfuvirtide in the POWER 3 analysis [abstract no. P54 plus poster]. 7th International Workshop on Clinical Pharmacology of HIV Therapy; 20-22 April 2006; Lisbon.
-
(2006)
7th International Workshop on Clinical Pharmacology of HIV Therapy
-
-
Sekar, V.1
De Paepe, E.2
Vangeneugden, T.3
-
23
-
-
34347329093
-
Efficacy and safety of darunavir- ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatmentexperienced HIV-infected patients in TITAN: A randomised controlled phase III trial
-
Madruga JV, Berger D, McMurchie M, et al. Efficacy and safety of darunavir- ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatmentexperienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet 2007; 370:49-58.
-
(2007)
Lancet
, vol.370
, pp. 49-58
-
-
Madruga, J.V.1
Berger, D.2
McMurchie, M.3
-
25
-
-
34047207229
-
Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
-
Clotet B, Bellos N, Molina JM, et al. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet 2007; 369:1169-1178.
-
(2007)
Lancet
, vol.369
, pp. 1169-1178
-
-
Clotet, B.1
Bellos, N.2
Molina, J.M.3
-
26
-
-
70349189262
-
Phenotypic and genotypic determinants of resistance to darunavir: Analysis of data from treatmentexperienced patients in POWER 1, 2, 3 and DUET-1 and 2
-
(abstract 31)
-
De Meyer S, Dierynck I, Lathouwers E, et al. Phenotypic and genotypic determinants of resistance to darunavir: analysis of data from treatmentexperienced patients in POWER 1, 2, 3 and DUET-1 and 2. Antivir Ther 2008; 13 (Suppl 3):A33 (abstract 31).
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
De Meyer, S.1
Dierynck, I.2
Lathouwers, E.3
-
27
-
-
60749130473
-
Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients
-
Descamps D, Lambert-Niclot S, Marcelin AG, et al. Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients. J Antimicrob Chemother 2009; 63:585-592.
-
(2009)
J Antimicrob Chemother
, vol.63
, pp. 585-592
-
-
Descamps, D.1
Lambert-Niclot, S.2
Marcelin, A.G.3
-
28
-
-
2342620790
-
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related nonnucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
-
Das K, Clark AD Jr, Lewi PJ, et al. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related nonnucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. JMed Chem 2004; 47:2550-2560.
-
(2004)
JMed Chem
, vol.47
, pp. 2550-2560
-
-
Das, K.1
Jr C.Ad2
Lewi, P.J.3
-
30
-
-
42149148283
-
Pharmacokinetics of amprenavir and TMC125 in HIV-infected volunteers receiving TMC125 with fosamprenavir/ ritonavir
-
[abstract A-370] September San Francisco
-
Scholler-Gyure M, Woodfall B, Bollen S, et al. Pharmacokinetics of amprenavir and TMC125 in HIV-infected volunteers receiving TMC125 with fosamprenavir/ ritonavir [abstract A-370]. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 2006; San Francisco.
-
(2006)
46th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Scholler-Gyure, M.1
Woodfall, B.2
Bollen, S.3
-
31
-
-
52349083907
-
Pharmacokinetic evaluation of nonnucleoside reverse transcriptase inhibitor TMC125 and integrase inhibitor raltegravir in healthy subjects
-
[abstract TUPDB02] Treatment & Prevention; July Sydney
-
Anderson MS, Kakuda TN, Miller JL, et al. Pharmacokinetic evaluation of nonnucleoside reverse transcriptase inhibitor TMC125 and integrase inhibitor raltegravir in healthy subjects [abstract TUPDB02. 4th IAS Conference on HIV Pathogenesis, Treatment & Prevention; July 2007; Sydney.
-
(2007)
4th IAS Conference on HIV Pathogenesis
-
-
Anderson, M.S.1
Kakuda, T.N.2
Miller, J.L.3
-
32
-
-
55049100707
-
An open randomised two period crossover study in 2 cohorts to investigate the effect of steady state TMC125 and the combination of TMC125/DRV/r on the steady state pharmacokinetics of oral maraviroc in healthy subjects
-
[abstract P4.3/02] October Madrid
-
Davis J, Scholler-Gyure M, Kakuda TN, et al. An open randomised two period crossover study in 2 cohorts to investigate the effect of steady state TMC125 and the combination of TMC125/DRV/r on the steady state pharmacokinetics of oral maraviroc in healthy subjects [abstract P4.3/02]. 11th European AIDS Conference; October 2007; Madrid.
-
(2007)
11th European AIDS Conference
-
-
Davis, J.1
Scholler-Gyure, M.2
Kakuda, T.N.3
-
33
-
-
34347327010
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24- week results from a randomized, double-blind, placebo controlled trial
-
Madruga JV, Cahn P, Grinsztejn B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24- week results from a randomized, double-blind, placebo controlled trial. Lancet 2007; 370:29-38.
-
(2007)
Lancet
, vol.370
, pp. 29-38
-
-
Madruga, J.V.1
Cahn, P.2
Grinsztejn, B.3
-
34
-
-
34347354196
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced patients in DUET-2: 24-week results from a randomized, double-blind, placebo-controlled trial
-
Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced patients in DUET-2: 24-week results from a randomized, double-blind, placebo-controlled trial. Lancet 2007; 370:39-48.
-
(2007)
Lancet
, vol.370
, pp. 39-48
-
-
Lazzarin, A.1
Campbell, T.2
Clotet, B.3
-
35
-
-
55749085253
-
Impact of reverse transcriptase resistance on the efficacy of TMC125 (etravirine) with two nucleoside reverse transcriptase inhibitors in protease inhibitor-naÿve, nonnucleoside reverse transcriptase inhibitor-experienced patients: Study TMC125-C227
-
Ruxrungtham K, Pedro RJ, Latiff GH, et al. Impact of reverse transcriptase resistance on the efficacy of TMC125 (etravirine) with two nucleoside reverse transcriptase inhibitors in protease inhibitor-naÿve, nonnucleoside reverse transcriptase inhibitor-experienced patients: study TMC125-C227. HIV Med 2008; 9:883-896.
-
(2008)
HIV Med
, vol.9
, pp. 883-896
-
-
Ruxrungtham, K.1
Pedro, R.J.2
Latiff, G.H.3
-
36
-
-
34147134958
-
Efficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: Primary 24-week analysis
-
Nadler JP, Berger DS, Blick G, et al. Efficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: primary 24-week analysis. AIDS 2007; 21:F1-F10.
-
(2007)
AIDS
, vol.21
-
-
Nadler, J.P.1
Berger, D.S.2
Blick, G.3
-
37
-
-
70350559546
-
Pooled 48-Week Analysis of DUET-1 and DUET-2: Durable efficacy and safety results of etravirine (ETR; TMC125) in treatment-experienced HIV-infected patients
-
Abstract PS 1/5
-
Cheret A, Katlama C, Trottier B, et al. Pooled 48-Week Analysis of DUET-1 and DUET-2: durable efficacy and safety results of etravirine (ETR; TMC125) in treatment-experienced HIV-infected patients. 15th ISHEID 2008. Abstract PS 1/5.
-
(2008)
15th ISHEID
-
-
Cheret, A.1
Katlama, C.2
Trottier, B.3
-
38
-
-
52249114260
-
An update of the list of NNRTI mutations associated with decreased virologic response to etravirine (ETR): Multivariate analyses on the pooled DUET-1 and DUET-2 clinical trial data
-
poster 24
-
Vingerhoets J, Peeters M, Azijn H, et al. An update of the list of NNRTI mutations associated with decreased virologic response to etravirine (ETR): multivariate analyses on the pooled DUET-1 and DUET-2 clinical trial data. 17th International HIV Drug Resistance Workshop; 2008; poster 24.
-
(2008)
17th International HIV Drug Resistance Workshop
-
-
Vingerhoets, J.1
Peeters, M.2
Azijn, H.3
-
40
-
-
54549118264
-
Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz
-
Llibre J, Santos J, Puig T, et al. Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz. J Antimicrob Chemother 2008; 62:909-913.
-
(2008)
J Antimicrob Chemother
, vol.62
, pp. 909-913
-
-
Llibre, J.1
Santos, J.2
Puig, T.3
-
41
-
-
70350541845
-
-
TMC114-TiDP31-C229: This is a Study on the Effectiveness, Safety and Tolerability of Darunavir (DRV), Administered With Low-Dose Ritonavir (Rtv) as 800/100 mg Daily Versus 600/100mg Twice Per Day for HIV-1 Patients Over a 48-Week Treatment Period. (NCT00524368)
-
TMC114-TiDP31-C229: This is a Study on the Effectiveness, Safety and Tolerability of Darunavir (DRV), Administered With Low-Dose Ritonavir (Rtv) as 800/100 mg Daily Versus 600/100mg Twice Per Day for HIV-1 Patients Over a 48-Week Treatment Period. (NCT00524368). http://clinicaltrials.gov/ ct2/show/NCT00524368?term=darunavir&rank=21
-
-
-
|