Optimization of mass transfer for toxin removal and immunoprotection of hepatocytes in a bioartificial liver

Biotechnology and Bioengineering

Volumn 104, Issue 5, 2009, Pages 995-1003

  Nedredal, Geir I ^a   Amiot, Bruce P ^b   Nyberg, Peter ^a   Luebke Wheeler, Jennifer ^a   Lillegard, Joseph B ^a   McKenzie, Travis J ^a   Nyberg, Scott L ^a,c  

^a MAYO CLINIC   (United States)

^b Brami Biomedical Inc   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Albumin; Ammonia; Bilirubin; Bioartificial liver; Mass transfer; TNF

Indexed keywords

ALBUMIN; BILIRUBIN; BIOARTIFICIAL LIVER; DEXTRAN POLYMERS; HEPATOCYTES; HEPATOTOXINS; HOLLOW FIBER MEMBRANES; IMMUNOPROTECTION; MEMBRANE PERMEABILITY; MEMBRANE PORE SIZE; MOLECULAR WEIGHT CUTOFF; OPTIMAL OPERATING CONDITIONS; TEST CONDITION;

AMMONIA; BIOLOGICAL MATERIALS PRESERVATION; CAPILLARITY; GLUCOSE; LIVER; MASS TRANSFER; MEMBRANE FOULING; MEMBRANES; OPTIMIZATION; TOXIC MATERIALS;

CELL MEMBRANES;

ALBUMIN; AMMONIA; BILIRUBIN; BILIRUBIN GLUCURONIDE; DEXTRAN; HEPATOTOXIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BIOARTIFICIAL LIVER; CELL COMPARTMENTALIZATION; CELL MEMBRANE PERMEABILITY; CONJUGATION; CONTROLLED STUDY; HOLLOW FIBER MEMBRANE; HUMAN; HUMAN CELL; IMMUNITY; LIVER CELL; MICROPROCESSOR; MOLECULAR WEIGHT; RANK SUM TEST;

ANIMALS; HEPATOCYTES; HUMANS; IMMUNOPRECIPITATION; LIVER, ARTIFICIAL; MICROPORE FILTERS; PERMEABILITY; PLASMA; SWINE; TOXINS, BIOLOGICAL;

SUIDAE;

EID: 70350523887     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22450     Document Type: Article

References (24)

1. Baquerizo A, Mhoya A, Kearns-Jonker M, Arnaout W, Shackleton C, Busuttil R, Demetriou A, Cramer D. 1999. Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment. Transplantation 67:5-18.
2. Brophy C, Nyberg S. 2008. Extracorporeal treatment of acute liver failure. Hepatol Res 38(Suppl 1):S34-S40.
3. Brophy CM, Luebke-Wheeler JL, Amiot BP, Khan H, Remmel RP, Rinaldo P, Nyberg SL. 2009. Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 49(2):578-586.
4. Demetriou A, Brown R, Busuttil R, Fair J, McGuire B, Rosenthal P, Schulte J, Lerut J, Nyberg S, Salizzoni M, Fagan E, de Hemptinne B, Broelsch C, Muraca M, Salmeron J, Rabkin J, Metselaar H, Pratt D, De La Mata M, McChesney L, Everson G, Lavin P, Stevens A, Pitkin Z, Solomon B. 2004. Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg 239:660-670. (Pubitemid 38525637)
5. Elin R. 2007. Reference intervals and laboratory values. In: Goldman JK, editor. Cecil medicine. 23rd edn. St. Louis, MO: Saunders.
6. Filippi C, Keatch S, Rangar D. 2004. Improvement of C3A metabolism for usage in bioartificial liver support systems. J Hepatol 41:499-505. (Pubitemid 39297795)
7. Gerlach J, Trost T, Ryan CJ, Meissler M, Hole O, Muller C, Neuhaus P. 1994. Hybrid liver support system in a short term application on hepatectomized pigs. Int J Artif Organs 17(10):549-553. (Pubitemid 24375890)
8. Lee W, Squires RJ, Nyberg S, Doo E, Hoofnagle J. 2008. Acute liver failure: Summary of a workshop. Hepatology 47:1401-1415. (Pubitemid 351547926)
9. Matsumura K, Guevara G, Huston H, Hamilton W, Rikimaru M, Yamasaki G, Matsumura M. 1987. Hybrid bioartificial liver in hepatic failure: Preliminary clinical report. Surgery 101:99-103. (Pubitemid 17218385)
10. Matsushita T, Amiot B, Hardin J, Platt J, Nyberg S. 2003. Membrane pore size impacts performance of a xenogeneic bioartificial liver. Transplantation 76:1299-1305. (Pubitemid 37430715)
11. Mavri-Damelin D, Eaton S, Damelin LH, Rees M, Hodgson HJ, Selden C. 2007. Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. Int J Biochem Cell Biol 39(3):555-564. (Pubitemid 46096793)
12. Mavri-Damelin D, Damelin LH, Eaton S, Rees M, Selden C, Hodgson HJ. 2008. Cells for bioartificial liver devices: The human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia. Biotechnol Bioeng 99:644-651. (Pubitemid 351158262)
13. McKenzie T, Lillegard J, Nyberg S. 2008. Artificial and bioartificial liver support. Semin Liver Dis 28:210-217.
14. Millis J, Losanoff J. 2005. Technology insight: Liver support systems. Nat Clin Pract Gastroenterol Hepatol 2:398-405. (Pubitemid 41486092)
15. Millis JM, Cronin DC, Johnson R, Conjeevaram H, Conlin C, Trevino S, Maguire P. 2002. Initial experience with the modified extracorporeal liver-assist device for patients with fulminant hepatic failure: System modifications and clinical impact. Transplantation 74(12):1735-1746. (Pubitemid 36019328)
16. Nyberg S, Platt J, Shirabe K, Payne W, Hu W-S, Cerra F. 1992. Immunoprotection of xenocytes in a hollow fiber bioartificial liver. ASAIO J 38:M463-M467.
17. Nyberg S, Yagi T, Matsushita T, Hardin J, Grande J, Gibson L, Platt J. 2003. Membrane barrier of a porcine hepatocyte bioartificial liver. Liver Transplant 9:298-305. (Pubitemid 36322333)
18. Nyberg S, Amiot B, Hardin J, Baskin Bey E, Platt J. 2004. Cytotoxic immune response to a xenogeneic bioartificial liver. Cell Transplant 13:783-791. (Pubitemid 40280216)
19. Nyberg SL, Hardin J, Amiot B, Argikar UA, Remmel RP, Rinaldo P. 2005. Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver. Liver Transplant 11(8):901-910. (Pubitemid 41122447)
20. Patzer J. 2006. Principles of bound solute dialysis. Ther Apher Dial 10:118-124.
21. Patzer JF II, Campbell B, Miller R. 2002. Plasma versus whole blood perfusion in a bioartificial liver assist device. ASAIO J 48(3):226-233. (Pubitemid 35006983)
22. Strain A, Neuberger J. 2002. A bioartificial liver - State of the art. Science 295:1005-1009.
23. Sussman NL, McGuire BM, Kelly JH. 2009. Hepatic assist devices: Will they ever be successful? Curr Gastroenterol Rep 11(1):64-68.
24. Wang L, Sun J, Li L, Mears D, Horvat M, Sheil A. 1998. Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system. Cell Transplant 7:459-468. (Pubitemid 29046550)