Negative roles of a novel nitrogen metabolite repression-related gene, TAR1, in laccase production and nitrate utilization by the basidiomycete Cryptococcus neoformans

Applied and Environmental Microbiology

Volumn 75, Issue 21, 2009, Pages 6777-6782

  Jiang, Nan ^a   Xiao, Dongguang ^b   Zhang, Defa ^a   Sun, Naiyu ^a   Yan, Bing ^a   Zhu, Xudong ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS NIDULANS; C-TERMINAL REGIONS; CRYPTOCOCCUS NEOFORMANS; HEAT SHOCK FACTORS; HIGH TEMPERATURE; LACCASE ACTIVITY; LACCASE PRODUCTION; LACCASES; MULTICOPPER OXIDASE LACCASE; NEUROSPORA CRASSA; PROMOTER REGION; PUTATIVE PROTEINS; ROSSMANN FOLD;

BINDING ENERGY; BINDING SITES; BIOMOLECULES; METABOLISM; METABOLITES;

NITROGEN;

FUNGAL PROTEIN; HEAT SHOCK PROTEIN; LACCASE; MESSENGER RNA; NITRATE; NITROGEN DERIVATIVE; REPRESSOR PROTEIN; TAR1 PROTEIN; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; GENE EXPRESSION; METABOLITE; PROTEIN; RNA; TEMPERATURE EFFECT; YEAST;

AMINO TERMINAL SEQUENCE; ARTICLE; ASPERGILLUS NIDULANS; BINDING SITE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ENZYME SYNTHESIS; FUNGAL GENE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE FUNCTION; NEUROSPORA CRASSA; NITROGEN UTILIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN MOTIF; PROTEIN STRUCTURE; REPRESSOR GENE; SEQUENCE HOMOLOGY; TAR1 GENE; TEMPERATURE; TRINUCLEOTIDE REPEAT;

BINDING SITES; CRYPTOCOCCUS NEOFORMANS; DNA, FUNGAL; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENE KNOCKOUT TECHNIQUES; LACCASE; MOLECULAR SEQUENCE DATA; NITRATES; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EMERICELLA NIDULANS; FILOBASIDIELLA NEOFORMANS; FUNGI; NEUROSPORA CRASSA;

EID: 70350520499     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00708-09     Document Type: Article

References (34)

1. Alspaugh, J. A., R. Pukkila-Worley, T. Harashima, L. M. Cavallo, D. Funnell, G. M. Cox, J. R. Perfect, J. W. Kronstad, and J. Heitman. 2002. Adenylyl cyclase functions downstream of the G-alpha protein GPA1 and controls mating and pathogenicity. Eukaryot. Cell 1:75-84.
2. Andrianopoulos, A., S. Kourambas, J. A. Sharp, M. A. Davis, and M. J. Hynes. 1998. Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression. J. Bacteriol. 180:1973-1977. (Pubitemid 28173086)
3. Asgher, M., H. N. Bhatti, M. Ashraf, and R. L. Legge. 2008. Recent developments in biodegradation of industrial pollutants by white rot fungi and their enzyme system. Biodegradation 19:771-783.
4. Bajpai, P., A. Anand, and P. K. Bajpai. 2006. Bleaching with lignin-oxidizing enzymes. Biotechnol. Annu. Rev. 12:349-378.
5. Balan, V., L. da Costa Sousa, S. P. Chundawat, R. Vismeh, A. D. Jones, and B. E. Dale. 2008. Mushroom spent straw: a potential substrate for an ethanolbased biorefinery. J. Ind. Microbiol. Biotechnol. 35:293-301.
6. Baldrian, P. 2006. Fungal laccases-occurrence and properties. FEMS Microbiol. Rev. 30:215-242.
7. Blackwood, C. B., M. P. Waldrop, D. R. Zak, and R. L. Sinsabaugh. 2007. Molecular analysis of fungal communities and laccase genes in decomposing litter reveals differences among forest types but no impact of nitrogen deposition. Environ. Microbiol. 9:1306-1316.
8. Chow, E. D., O. W. Liu, S. O'Brien, and H. D. Madhani. 2007. Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Curr. Genet. 52:137-148.
9. Gomez, D., I. Garcia, C. Scazzocchio, and B. Cubero. 2003. Multiple GATA sites: protein binding and physiological relevance for the regulation of the proline transporter gene of Aspergillus nidulans. Mol. Microbiol. 50:277-289.
10. Hager, G., E. Eckert, and F. W. Schwaiger. 1999. Semiquantitative analysis of low levels of mRNA expression from small amounts of brain tissue by nonradioactive reverse transcriptase-polymerase chain reaction. J. Neurosci. Methods 89:141-149. (Pubitemid 29361509)
11. Hashikawa, N., N. Yamamoto, and H. Sakurai. 2007. Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements. J. Biol. Chem. 282:10333-10340.
12. Horikoshi, T., and M. Sakakibara. 2000. Quantification of relative mRNA expression in the rat brain using simple RT-PCR and ethidium bromide staining. J. Neurosci. Methods 99:45-51. (Pubitemid 30628792)
13. Idnurm, A., Y. S. Bahn, K. Nielsen, X. Lin, J. A. Fraser, and J. Heitman. 2005. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat. Rev. Microbiol. 3:753-764.
14. Jacobson, E. S., and H. S. Emery. 1991. Temperature regulation of the cryptococcal phenoloxidase. J. Med. Vet. Mycol. 29:121-124.
15. Martínez, A. T., M. Speranza, F. J. Ruiz-Dueñas, P. Ferreira, S. Camarero, F. Guillén, M. J. Martínez, A. Gutiérrez, and J. C. del Río. 2005. Biodegradation of lignocellulosics: microbial, chemical, and enzymatic aspects of the fungal attack of lignin. Int. Microbiol. 8:195-204.
16. Marzluf, G. A. 1997. Genetic regulation of nitrogen metabolism in the fungi. Microbiol. Mol. Biol. Rev. 61:17-32.
17. Mikolasch, A., and F. Schauer. 2009. Fungal laccases as tools for the synthesis of new hybrid molecules and biomaterials. Appl. Microbiol. Biotechnol. 82:605-624.
18. Missall, T. A., J. M. Moran, J. A. Corbett, and J. K. Lodge. 2005. Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. Eukaryot. Cell 4:202-208.
19. Nurudeen, T. A., and D. G. Ahearn. 1979. Regulation of melanin production by Cryptococcus neoformans. J. Clin. Microbiol. 10:724-729.
20. Perfect, J. R., D. L. Toffaletti, and T. H. Rude. 1993. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61:4446-4451.
21. Platt, A., T. Langdon, H. N. Arst, D. Kirk, D. Tollervey, J. M. M. Sanchez, and M. X. Caddick. 1996. Nitrogen metabolite signaling involves the Cterminus and the GATA domain of the Aspergillus transcription factor AREA and the 3′ untranslated region of its mRNA. EMBO J. 15:2791-2801. (Pubitemid 26176256)
22. Riva, S. 2006. Laccases: blue enzymes for green chemistry. Trends Biotechnol. 24:219-226.
23. Rodríguez Couto, S., and J. L. Toca Herrera. 2006. Industrial and biotechnological applications of laccases: a review. Biotechnol. Adv. 24:500-513.
24. Rosa e Silva, L. K., C. C. Staats, L. S. Goulart, L. G. Morello, M. H. Pelegrinelli Fungaro, A. Schrank, and M. H. Vainstein. 2008. Identification of novel temperature-regulated genes in the human pathogen Cryptococcus neoformans using representational difference analysis. Res. Microbiol. 159: 221-229.
25. Salas, S. D., J. E. Bennett, K. J. Kwon-Chung, J. R. Perfect, and P. R. Williamson. 1996. Effect of the laccase gene LAC1 on virulence of Cryptococcus neoformans. J. Exp. Med. 184:377-386.
26. Stammers, D. K., J. Ren, K. Leslie, C. E. Nichols, H. K. Lamb, S. Cocklin, A. Dodds, and A. R. Hawkins. 2001. The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. EMBO J. 20:6619-6626.
27. Steen, B. R., T. Lian, S. Zuyderduyn, W. K. MacDonald, M. Marra, S. J. Jones, and J. W. Kronstad. 2002. Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans. Genome Res. 12:1386-1400.
28. Wesenberg, D., I. Kyriakides, and S. N. Agathos. 2003. White-rot fungi and their enzymes for the treatment of industrial dye effluents. Biotechnol. Adv. 22:161-187.
29. Williamson, P. R. 1994. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J. Bacteriol. 176:656-664.
30. Williamson, P. R., K. Wakamatsu, and S. Ito. 1998. Melanin biosynthesis in Cryptococcus neoformans. J. Bacteriol. 180:1570-1572.
31. Xiao, X., Y. H. Fu, and G. A. Marzluf. 1995. The negative-acting NMR regulatory protein of Neurospora crassa binds to and inhibits the DNAbinding activity of the positive-acting nitrogen regulatory protein NIT2. Biochemistry 34:8861-8868.
32. Zheng, X., X. Dai, Y. Zhao, Q. Chen, F. Lu, D. Yao, Q. Yu, X. Liu, C. Zhang, X. Gu, and M. Luo. 2007. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc. Natl. Acad. Sci. USA 104:8809-8814.
33. Zhu, X., and P. R. Williamson. 2003. A CLC-type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformans. Mol. Microbiol. 50:1271-1281.
34. Zhu, X., and P. R. Williamson. 2004. Role of laccase in the biology and virulence of Cryptococcus neoformans. FEMS Yeast Res. 5:1-10. (Pubitemid 39285980)