A causal association between isotretinoin and inflammatory bowel disease has yet to be established

American Journal of Gastroenterology

Volumn 104, Issue 10, 2009, Pages 2387-2393

  Crockett, Seth D ^a   Gulati, Ajay ^a   Sandler, Robert S ^a   Kappelman, Michael D ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTRETINOIN; DERMATOLOGICAL AGENT;

ACNE; ARTICLE; CASE REPORT; CASE STUDY; COLITIS; COLLAGENOUS COLITIS; CROHN DISEASE; DATA ANALYSIS; DIARRHEA; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EXPOSURE; DRUG SAFETY; DRUG WITHDRAWAL; ENTERITIS; GASTRITIS; GEOGRAPHIC DISTRIBUTION; HEMORRHAGIC COLITIS; HUMAN; PRIORITY JOURNAL; PROCTITIS; RISK ASSESSMENT; TREATMENT DURATION; ULCERATIVE COLITIS; CHEMICALLY INDUCED DISORDER; EPIDEMIOLOGY; REVIEW;

CAUSALITY; DERMATOLOGIC AGENTS; HUMANS; INFLAMMATORY BOWEL DISEASES; ISOTRETINOIN;

EID: 70350520126     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.334     Document Type: Article

References (39)

1. Ahmed R, Pezzone M. Isotretinoin-associated ulcerative colitis. Am J Gastroenterol 2006; 101:S394
2. Bankar RN, Dafe CO, Kohnke A et al. Ulcerative colitis probably associated with isotretinoin. Indian J Gastroenterol 2006; 25:171-172
3. Borobio E, Arin A, Valcayo A et al. [Isotretinoin and ulcerous colitis]. An Sist Sanit Navar 2004; 27:241-243 Spanish
4. Mennecier D, Poyet R, Thiolet C et al. Ulcerative colitis probably induced by isotretinoin. Gastroenterol Clin Biol 2005; 29:1306-1307
5. Reniers DE, Howard JM. Isotretinoin-induced inflammatory bowel disease in an adolescent. Ann Pharmacother 2001; 35:1214-1216
6. Rolanda C, Macedo G. Isotretinoin and inflammatory bowel disease. Am J Gastroenterol 2007; 102:1330
7. Accutane [package insert] (November 2008)
8. Reddy D, Siegel CA, Sands BE et al. Possible association between isotretinoin and inflammatory bowel disease. Am J Gastroenterol 2006; 101:1569-1573
9. Hill AB. The environment and disease: association or causation? Proc R Soc Med 1965; 58:295-300
10. Brodin MB. Inflammatory bowel disease and isotretinoin. J Am Acad Dermatol 1986; 14:843
11. Deplaix P, Barthelemy C, Vedrines P et al. [Probable acute hemorrhagic colitis caused by isotretinoin with a test of repeated administration]. Gastroenterol Clin Biol 1996; 20:113-114 French
12. Martin P, Manley PN, Depew WT et al. Isotretinoin-associated proctosigmoiditis. Gastroenterology 1987; 93:606-609
13. Melki M, Pouderoux P, Pignodel C et al. [Granulomatous colitis likely induced by isotretinoin]. Gastroenterol Clin Biol 2001; 25:433-435 French
14. Moneret-Vautrin DA, Delvaux M, Labouyrie E et al. Collagenous colitis: possible link with isotretinoin. Eur Ann Allergy Clin Immunol 2006; 38:124-125
15. Spada C, Riccioni ME, Marchese M et al. Isotretinoin-associated panenteritis. J Clin Gastroenterol 2008; 42:923-925
16. Passier JL, Srivastava N, van Puijenbroek EP. Isotretinoin-induced inflammatory bowel disease. Neth J Med 2006; 64:52-54
17. Loftus EV Jr., Silverstein MD, Sandborn WJ et al. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology 1998; 114:1161-1168
18. Stonnington CM, Phillips SF, Melton LJ 3rd et al. Chronic ulcerative colitis: incidence and prevalence in a community. Gut 1987; 28:402-409
19. Wysowski DK, Swann J, Vega A. Use of isotretinoin (Accutane) in the United States: rapid increase from 1992 through 2000. J Am Acad Dermatol 2002; 46:505-509
20. US Census Bureau. US Population Clock. Accessed 6 February 2009
21. Brewer T, Colditz GA. Postmarketing surveillance and adverse drug reactions: current perspectives and future needs. JAMA 1999; 281:824-829
22. Guslandi M. Isotretinoin and inflammatory bowel disease. Am J Gastroenterol 2007; 102:1546-1547
23. Bruno NP, Beacham BE, Burnett JW. Adverse effects of isotretinoin therapy. Cutis 1984; 33:484-6, 489
24. Dessoukey MW, Omar MF, Dayem HA. Pyoderma faciale: manifestation of inflammatory bowel disease. Int J Dermatol 1996; 35:724-726
25. Ali M, Duerksen DR. Ulcerative colitis and Sweet's syndrome: a case report and review of the literature. Can J Gastroenterol 2008; 22:296-298 (Pubitemid 351676391)
26. Osanai M, Nishikiori N, Murata M et al. Cellular retinoic acid bioavailability determines epithelial integrity: role of retinoic acid receptor alpha agonists in colitis. Mol Pharmacol 2007; 71:250-258
27. Mucida D, Park Y, Kim G et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317:256-260
28. Mora JR, von Andrian UH. Role of retinoic acid in the imprinting of guthoming IgA-secreting cells. Semin Immunol 2009; 21:28-35
29. Guruvayoorappan C, Kuttan G. 13 cis-retinoic acid regulates cytokine production and inhibits angiogenesis by disrupting endothelial cell migration and tube formation. J Exp Ther Oncol 2008; 7:173-182
30. Rosen T, Unkefer RP. Treatment of pyoderma faciale with isotretinoin in a patient with ulcerative colitis. Cutis 1999; 64:107-109
31. Godfrey KM, James MP. Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease. Br J Dermatol 1990; 123:653-655
32. McHenry PM, Hudson M, Smart LM et al. Pyoderma faciale in a patient with Crohn's disease. Clin Exp Dermatol 1992; 17:460-462
33. Schleicher SM. Oral isotretinoin and inflammatory bowel disease. J Am Acad Dermatol 1985; 13:834-835
34. Tsianos EV, Dalekos GN, Tzermias C et al. Hidradenitis suppurativa in Crohn's disease. A further support to this association. J Clin Gastroenterol 1995; 20:151-153
35. Macdonald Hull S, Cunliffe WJ. The safety of isotretinoin in patients with acne and systemic diseases. J Dermatol Treat 1989; 1:35-37
36. Kappelman MD, Rifas-Shiman SL, Kleinman K et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol 2007; 5:1424-1429
37. Peck GL, Olsen TG, Butkus D et al. Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study. J Am Acad Dermatol 1982; 6:735-745
38. Lammer EJ, Chen DT, Hoar RM et al. Retinoic acid embryopathy. N Engl J Med 1985; 313:837-841
39. Fender AB, Ignatovich Y, Mercurio MG. Pyoderma faciale. Cutis 2008; 81:488-90.