Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium

Human Reproduction

Volumn 24, Issue 11, 2009, Pages 2736-2745

  Gomes, M K O ^a   Rosa E Silva, J C ^a   Garcia, S B ^a   De Sá Rosa E Silva, A C Japur ^a   Turatti, A ^a   Vieira, C S ^a   Ferriani, R A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Endometriosis; GnRH agonist; Levonorgestrel releasing intrauterine system; Steroid receptor

Indexed keywords

BIOLOGICAL MARKER; CYCLINE; ESTROGEN RECEPTOR ALPHA; FAS ANTIGEN; LEUPRORELIN; LEVONORGESTREL; PROGESTERONE RECEPTOR A;

ADULT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIOSIS; FEMALE; HUMAN; HUMAN TISSUE; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 70350514753     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dep288     Document Type: Article

References (49)

1. Atasoy P, Bozdogan O, Erekul S, Bozdogan N, Bayram M. Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium. Gynecol Oncol 2003;91:309-317.
2. Bahamondes L, Petta CA, Feranandes A, Monteiro I. Use of levonorgestrel-releasing intrauterine system in women with endometriosis, chronic pelvic pain and dysmenorrheal. Contraception 2007;75:S134-S139.
3. Bergqvist A, Ljungberg O, Skoog L. Immunohistochemical analysis of oestrogen and progesterone receptors in endometriotic tissue and endometrium. Hum Reprod 1993;8:1915-1922. (Pubitemid 23337158)
4. Bilotas M, Barañao RI, Buquet R, Sueldo C, Tesone M, Meresman GF. Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL proteins in endometrial epithelial cell cultures from patients with endometriosis and controls. Hum Reprod 2007; 22:644-653.
5. Braun DP, Ding J, Shen J, Rana N, Fernandez BB, Dmowski WP. Relationship between apoptosis and the number of macrophages in eutopic endometrium from women with and without endometriosis. Fertil Steril 2002;78:830-835.
6. Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 1997;275:1122-1126.
7. Critchley HOD, Tong S, Cameron ST, Drudy TA, Kelly RW, Baird DT. Regulation of bcl-2 gene family members in human endometrium by antiprogestin administration in vivo. J Reprod Fertil 1999;115:389-395.
8. Curtin JF, Cotter TG. Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell Signal 2003;15:983-992.
9. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116:205-219.
10. de Sá Rosa e Silva AC, Rosa e Silva JC, Nogueira AA, Petta CA, Abrão MS, Ferriani RA. The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis. Fertil Steril, 2006, 86, 742-744.
11. Dmowski WP, Ding J, Shen, Rana N, Fernandez BB, Braun DP. Apoptosis in endometrial glandular and stromal cells in women with or without endometriosis. Hum Reprod 2001;16:1802-1808.
12. Fujishita A, Hauso A, Khan KN, Masuzaki H, Nakashima H, Ishimaru T. Immunohistochemical study of angiogenic factors in endometrium and endometriosis. Gynecol Obstet Invest 1999;48(Suppl.1):36-44.
13. Gebel HM, Braun DP, Tambur A, Frame D, Rana N, Dmowski DP. Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis. Fertil Steril 1998;9:1042-1047.
14. Gomes MKO, Ferriani RA, Rosa e Silva JC, De Sá Rosa e Silva AC, Vieira CS, Reis FJC, Nogueira AA. The levonorgestrel-releasing intrauterine system and endometriosis staging. Fertil Steril 2007;87:1231-1233.
15. Huang A, Pettigrew NM, Watson PH. Immunohistochemical assay for oestrogen receptors in paraffin wax sections of breast carcinoma using a new monoclonal antibody. J Pathol 1996;180:223-227.
16. Imai A, Tamaya T. GnRH receptor and apoptotic signaling. Vitam Horm 2000;59:1-33.
17. Imai A, Takagi A, Tamaya T. Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro. Am J Obstet Gynecol 2000;182:1142-1146.
18. Janne O, Ylostalo P. Endometrial estrogen and progestin receptors in women bearing a progesterone-releasing intrauterine device. Contraception 1980;22:19-23.
19. Johnson MC, Torres M, Alves A, Bacallao K, Fuentes A, Vega M, Boric MA. Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-myc, TGF-beta1 and bax genes. Reprod Biol Endocrinol 2005;3:45.
20. Jones RK, Bulmer JN, Searle RF. Immunohistochemical characterization of proliferation, oestrogen receptor and progesterone receptor expression in endometriosis: comparison of eutopic and ectopic endometrium with normal cycling endometrium. Hum Reprod 1995;10:3272-3279.
21. Lessey BA, Killam AP, Metzger DA, Haney AF, Greene GL, McCarty KS Jr. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 1988;67:334-340.
22. Lockhat FB, Emembolu JO, Konje JC. The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up. Hum Reprod 2005;20:789-793.
23. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001;104:487-501.
24. Lu SM. Effect of levonorgestrel intrauterine device on human endometrial estrogen and progesterone receptors. Chin J Obstet Gynecol 1991; 26:293-294.
25. Luukkainen T, Toivonen J. Levonorgestrel-releasing IUD as a method of contraception with therapeutic properties. Contraception 1995; 52:269-276.
26. Maruo T, Laoag-Fernandez JB, Pakarinen P, Murakoshi H, Spitz IM, Johansson E. Use of a levonorgestrel intrauterine system on proliferation and apoptosis in the endometrium. Hum Reprod 2001; 16:2103-2108.
27. Matsuzaki S, Uehara T, Murakami J, Fujiwara J, Funato T, Okamura K. Quantitative analysis of estrogen receptor alpha and beta messenger ribonucleic acid levels in normal endometrium and ovarian endometriotic cysts using a real-time reverse transcription-polymerase chain reaction assay. Fertil Steril 2000;74:753-759.
28. Meresman GF, Vighi S, Buquet RA, Contreras-Ortiz O, Tesone M, Rumi LS. Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis. Fertil Steril 2000; 74:760-766.
29. Meresman GF, Augé L, Barañao RI, Lombardi E, Tesone M, Sueldo C. Oral contraceptives treatment suppresses proliferation and enhances apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertil Steril 2002;77:1141-1147.
30. Meresman GF, Buquet RA, Bilotas M, Barañao RI, Sueldo C, Tesone M. Gonadotropin-releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis. Fertil Steril 2003;80(Suppl.2):702-707.
31. Mizutani T, Sugihara A, Nakamuro K, Suehara N, Terada N. The gonadotropin-releasing hormone agonist leuprolide acetate induces apoptosis and suppresses cell proliferative activity in rectovaginal endometriosis. Am J Obstet Gynecol 1999;181:750-751.
32. Mylonas I, Jeschke U, Shabani N, Kuhn C, Kunze S, Dian D, Friedl C, Kupka MS, Friese K. Steroid receptors ERa, ERß, PR-A and PR-B are differentially expressed in normal and atrophic human endometrium. Histol Histopathol 2007;22:169-176.
33. Nilsson CG, Haukkamaa M, Vierola H, Luukkainen T. Tissue concentrations of levonorgestrel in women using a levonorgestrel releasing IUD. Clin Endocrinol (Oxf) 1982;17:529-536.
34. Nilsson CG, Lahteenmaki P, Luukkainen T. Ovarian function in amenorrhoeic and menstruating users of levonorgestrel-releasing intrauterine devices. Fertil Steril 1984;41:52-55.
35. Nisolle M, Casanas-Roux F, Donnez J. Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis. Fertil Steril 1997;68:912-919.
36. Otsuki Y, Misaki O, Sugimoto O, Ito Y, Tsujimoto Y, Akao Y. Ciclic bcl-2 gene expression in human uterine endometrium during menstrual cycle. Lancet 1994;344:28-29.
37. Pengdi Z, Xiaoqun L, Hongzhi L, Zhao G, Jie C, Ruhua X, Shizhu L, Shangchun W, Jiedong W. The effect of a levonorgestrel-releasing intrauterine device on human endometrial oestrogen and progesterone receptors after one year of use. Hum Reprod 1999;14:970-975.
38. Petta CA, Ferriani RA, Abrao MS, Hassan D, Rosa e Silva JC, Podgaec S, Bahamondes L. Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis. Hum Reprod 2005; 20:1993-1998.
39. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817-821.
40. Rotello R, Lieberman RC, Lepoff RB, Gerschenson LE. Characterization of uterine epithelium apoptotic cell death kinetics and regulation by progesterone and RU 486. Am J Pathol 1992;140:449-456.
41. Sharpe-Timms KL. Endometrial anomalies in women with endometriosis. Ann NY Acad Sci 2001;943:131-147.
42. Tabibzadeh S. Signals and molecular pathways involved in apoptosis with special emphasis on human endometrium. Hum Reprod 1995;1:303-323.
43. Vercellini P, Frontino G, De Giorgi O, Aimi G, Zaina B, Crosignani PG. Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study. Fertil Steril 2003;80:305-309.
44. Vereide AB, Kaino T, Sager G, Arnes M, Orbo A. Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptor (ER-alpha and ER-beta) in human endometrial hyperplasia. Gynecol Oncol 2006;101:214-223.
45. Wang Y, Matsuo H, Kurachi O, Maruo T. Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells. Eur J Endocrinol 2002; 146:447-456.
46. Watanabe H, Kanzaki H, Narukawa S, Inoue T, Katsuragawa H, Kaneko Y, Mori T. Bcl-2 and Fas expression in eutopic and ectopic endometrium during the menstrual cycle in relation to endometrial cell apoptosis. Am J Obstet Gynecol 1997;176:360-368.
47. Woodforde JM, Merskey H. Some relationships between subjective measures of pain. J Psychosom Res 1972;16:173-178.
48. World Health Organization. Medical Eligibility Criteria for Contraceptives, 3rd edn. Geneva: WHO, 2004, 186.
49. Yamashita H, Otsuki Y, Matsumoto K, Ueki K, Ueki M. Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle. Mol Human Reprod 1999;5:358-364.