Antimicrobial polymers prepared by ring-opening metathesis polymerization: Manipulating antimicrobial properties by organic counterion and charge density variation

Chemistry - A European Journal

Volumn 15, Issue 43, 2009, Pages 11715-11722

  Lienkamp, Karen ^a   Madkour, Ahmad E ^a   Kumar, Kushi Nidhi ^a   Nüsslein, Klaus ^a   Tew, Gregory N ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Antimicrobial polymers; Ion exchange; Oxanorbornene; Peptidomimetics; Ring opening metathesis polymerization

Indexed keywords

ANION EXCHANGE; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; ANTIMICROBIAL POLYMERS; ANTIMICROBIAL PROPERTY; BIOLOGICAL PROPERTIES; CATIONIC GROUPS; COUNTERIONS; HEMOLYTIC ACTIVITY; ION PAIRS; MEMBRANE ACTIVITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CHARGE; OXANORBORNENE; PEPTIDOMIMETICS; POLYMER BACKBONES; RING-OPENING METATHESIS POLYMERIZATION; STAPHYLOCOCCUS AUREUS; SYNTHESIS AND CHARACTERIZATION;

AMINES; ION EXCHANGE; ION EXCHANGERS; IONS; ORGANIC POLYMERS; POLYMERS; SYNTHESIS (CHEMICAL);

RING OPENING POLYMERIZATION;

ANTIINFECTIVE AGENT; BIOMIMETIC MATERIAL; CATION; DIAMINE; POLYMER;

ARTICLE; CHEMISTRY; HEMOLYSIS; HYDROPHOBICITY; MICROBIOLOGICAL EXAMINATION;

ANTI-INFECTIVE AGENTS; BIOMIMETIC MATERIALS; CATIONS; DIAMINES; HEMOLYSIS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; POLYMERS;

EID: 70350510812     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200900606     Document Type: Article

References (32)

1. E. Klein, D. L. Smith, R. Laxminarayan, Emerging Infect. Dis. 2007, 13, 1840.
2. K. Okuma, K. Iwakawa, J. Turnidge, W. B. Grubb, J. M. Bell, F G. O'Brien, G. W. Coombs, J. W. Pearman, F C Tenover, M. Kapi, C Tiensasitorn, T. Ito, K. Hiramatzu, J. Clin. Microbiol. 2002, 40, 4289.
3. A. E. Madkour, G. N. Tew, Polym. Int. 2008, 57, 6.
4. K. A. Brodgen, Nat. Rev. Microbiol. 2005, 3, 238.
5. D. Smith, E. B. Pentzer, S. T. Nguyen, Polym. Rev. 2007, 47, 419.
6. E.-R. Kenawy, S. D. Worley, R. Broughton, Biomacromolecules 2007, 8, 1359.
7. M. Zasloff, Nature 2002, 415, 389.
8. T. Eren, A. Som, J. R. Rennie, C F Nelson, Y. Urgina, K. Nüsslein, E. B. Coughlin, G. N. Tew, Macromol. Chem. Phys. 2008, 209, 516.
9. J. Varkey, R. Nagaraj, Antimicrob. Agents Chemother. 2005, 49, 4561.
10. J. Harder, J. Bartels, E. Christophers, J.-M. Schröder, J. Biol. Chem. 2001, 276, 5707.
11. M. F Ilker, K. Nüsslein, G.N. Tew, E. B. Coughlin, J. Am. Chem. Soc. 2004, 126, 15870.
12. K. Kuroda, W. F DeGrado, J. Am. Chem. Soc. 2005, 127, 4128.
13. K. Lienkamp, A. E. Madkour, A. Musante, C. F. Nelson, K. Nüsslein, G. N. Tew, J. Am. Chem. Soc. 2008, 130, 9836.
14. B. P. Mowery, S. E. Lee, D. A. Kissounko, R. F Epand, R. M. Epand, B. Weisblum, S. S. Stahl, S. H. Gellman, J. Am. Chem. Soc. 2007, 129, 15474.
15. G.J. Gabriel, J. A. Maegerlein, CF. Nelson, J. M. Dabkowski, T. Eren, K. Nüsslein, G. N. Tew, Chem. Eur. J. 2009,15, 433.
16. G.J. Gabriel, J. G. Pool, A. Som, J. M. Dabkowski, E. B. Coughlin, M. Muthukumar, G. N. Tew, Langmuir 2008, 24, 12489.
17. Z. M. Al-Badri, A. Som, S. Lyon, C F Nelson, K. Nüsslein, G. N. Tew, Biomacromolecules 2008, 9, 2805.
18. A. Kanazawa, T. Ikeda, T. Endo, J. Polym. Sci. Part A: Polym. Chem. 1993, 31, 1441.
19. C Z. Chen, N. C Beck-Tan, P. Dhurjati, T. K. V. Dyk, R. A. LaRossa, S. L. Cooper, Biomacromolecules 2000, 1, 473.
20. E. F Panarin, M. V. Solovaskii, N. A. Zaikina, G. E. Afinogenov, Makromol. Chem. Suppl. 1985, 9, 25.
21. V. Sambhy, B. R. Peterson, A. Sen, Angew. Chem. 2008, 120, 1270;
22. Angew. Chem. Int. Ed. 2008, 47, 1250.
23. A. Kanazawa, T. Ikeda, T. Endo, J. Polym. Sci. Part A 1993, 31, 3031.
24. K. Lienkamp, G.N. Tew, Chem. Eur. J. 2009, DOI: 10.1002/chem.200900049.
25. B. P. Mowery, A. H. Lindner, B. Weisblum, S. S. Stahl, S. H. Gellman, J. Am. Chem. Soc. 2009, 131, 9735.
26. J. A. Love, J. P. Morgan, T. M. Trnka, R. H. Grubbs, Angew. Chem. 2002, 114, 4207;
27. Angew. Chem. Int. Ed. 2002, 41, 4035.
28. J. Rennie, L. Amt, H. Tang, K. Nuesslein, G. N. Tew, J. Ind. Microbiol. Biotechnol. 2005, 32, 296.
29. K. Lienkamp, K.-N. Kumar, A. Som, K. Nüsslein, G. N. Tew, Chem. Eur. J. 2009, 10.1002/chem.200802558.
30. A. Som, G. N. Tew, J. Phys. Chem. B 2008, 112, 3495.
31. A. Som, S. Vemparala, I. Ivanov, G. N. Tew, Biopolymers 2008, 90, 83.
32. M. Pasupuleti, B. Walse, B. Svensson, M. Malmsten, A. Schmidtchen, Biochemistry 2008, 47, 9057.