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Volumn 33, Issue 8, 2009, Pages 447-455

Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; ANHYDROECGONINE ETHYL ESTER; ANHYDROECGONINE METHYL ESTER; BENZOYLECGONINE; COCAINE; HOMOCOCAINE; M HYDROXYBENZOYLECGONINE; METHANOL; NORCOCAINE; UNCLASSIFIED DRUG;

EID: 70350501864     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.8.447     Document Type: Article
Times cited : (26)

References (67)
  • 1
    • 27844553155 scopus 로고    scopus 로고
    • Cocaine
    • 2nd ed., B. Levine, Ed. AACC Press,Washington, D.C.
    • D.S. Isenschmid. Cocaine. In Principles of Forensic Toxicology, 2nd ed., B. Levine, Ed. AACC Press,Washington, D.C., 2003, pp 207-228.
    • (2003) Principles of Forensic Toxicology , pp. 207-228
    • Isenschmid, D.S.1
  • 2
    • 4344638467 scopus 로고    scopus 로고
    • Cocaine - Effects on human performance and behavior
    • D.S. Isenschmid. Cocaine - effects on human performance and behavior. Forensic Sci. Rev. 14: 61 (2002).
    • (2002) Forensic Sci. Rev. , vol.14 , pp. 61
    • Isenschmid, D.S.1
  • 3
    • 85036794459 scopus 로고    scopus 로고
    • Accessed February 5, 2008
    • Cocaine. http://www.usdoj.gov/dea/concern/cocaine.html. Accessed February 5, 2008.
    • Cocaine
  • 4
    • 84878647729 scopus 로고    scopus 로고
    • Accessed February 5, 2008
    • NIDA InfoFacts: Crack and Cocaine. http://www.nida.nih.gov/Info facts/cocaine.html. Accessed February 5, 2008.
    • NIDA InfoFacts: Crack and Cocaine
  • 5
    • 60549099527 scopus 로고    scopus 로고
    • Substance Abuse and Mental Health Services Administration. NSDUH Series H-34, DHHS Publication No. SMA 08-4343. Office of Applied Studies, SAMHSA, Rockville, MD
    • Substance Abuse and Mental Health Services Administration. Results from the 2007 National Survey on Drug Use and Health: National Findings, NSDUH Series H-34, DHHS Publication No. SMA 08-4343. Office of Applied Studies, SAMHSA, Rockville, MD, 2008.
    • (2008) Results from the 2007 National Survey on Drug Use and Health: National Findings
  • 6
    • 0025955766 scopus 로고
    • Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine
    • R.A. Dean, C.D. Christian, R.H. Sample, and W.F. Bosron. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J. 5: 2735-2739 (1991).
    • (1991) FASEB J. , vol.5 , pp. 2735-2739
    • Dean, R.A.1    Christian, C.D.2    Sample, R.H.3    Bosron, W.F.4
  • 7
    • 33750183625 scopus 로고    scopus 로고
    • Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration
    • E.A. Kolbrich, A.J. Barnes, D.A. Gorelick, S.J. Boyd, E.J. Cone, and M.A. Huestis. Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration. J. Anal. Toxicol. 30: 501-510 (2006).
    • (2006) J. Anal. Toxicol. , vol.30 , pp. 501-510
    • Kolbrich, E.A.1    Barnes, A.J.2    Gorelick, D.A.3    Boyd, S.J.4    Cone, E.J.5    Huestis, M.A.6
  • 10
    • 0033809550 scopus 로고    scopus 로고
    • Simultaneous GC-MS analysis of meta- and para-hydroxybenzoylecgonine and norbenzoylecgonine: A secondary method to corroborate cocaine ingestion using nonhydrolytic metabolites
    • K.L. Klette, G.K. Poch, R. Czarny, and C.O. Lau. Simultaneous GC-MS analysis of meta- and para-hydroxybenzoylecgonine and norbenzoylecgonine: a secondary method to corroborate cocaine ingestion using nonhydrolytic metabolites. J. Anal. Toxicol. 24: 482-488 (2000).
    • (2000) J. Anal. Toxicol. , vol.24 , pp. 482-488
    • Klette, K.L.1    Poch, G.K.2    Czarny, R.3    Lau, C.O.4
  • 11
    • 0020632379 scopus 로고
    • N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase
    • M.W. Kloss, G.M. Rosen, and E.J. Rauckman. N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase. Mol. Pharmacol. 23: 482-485 (1983).
    • (1983) Mol. Pharmacol. , vol.23 , pp. 482-485
    • Kloss, M.W.1    Rosen, G.M.2    Rauckman, E.J.3
  • 12
    • 0021368745 scopus 로고
    • Cocaine-mediated hepatotoxicity. A critical review
    • M.W. Kloss, G.M. Rosen, and E.J. Rauckman. Cocaine-mediated hepatotoxicity. A critical review. Biochem. Pharmacol. 33: 169-173 (1984).
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 169-173
    • Kloss, M.W.1    Rosen, G.M.2    Rauckman, E.J.3
  • 13
    • 0034284977 scopus 로고    scopus 로고
    • Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species
    • F. Boess, F.M. Ndikum-Moffor, U.A. Boelsterli, and S.M. Roberts. Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species. Biochem. Pharmacol. 60: 615-623 (2000).
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 615-623
    • Boess, F.1    Ndikum-Moffor, F.M.2    Boelsterli, U.A.3    Roberts, S.M.4
  • 17
    • 0025763080 scopus 로고
    • Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion
    • P. Jatlow, J.D. Elsworth, C.W. Bradberry, G. Winger, J.R. Taylor, R. Russell, and R.H. Roth. Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life Sci. 48: 1787-1794 (1991).
    • (1991) Life Sci. , vol.48 , pp. 1787-1794
    • Jatlow, P.1    Elsworth, J.D.2    Bradberry, C.W.3    Winger, G.4    Taylor, J.R.5    Russell, R.6    Roth, R.H.7
  • 18
    • 0027948970 scopus 로고
    • Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine
    • M.R. Brzezinski, T.L. Abraham, C.L. Stone, R.A. Dean, and W.F. Bosron. Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem. Pharmacol. 48: 1747-1755 (1994).
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1747-1755
    • Brzezinski, M.R.1    Abraham, T.L.2    Stone, C.L.3    Dean, R.A.4    Bosron, W.F.5
  • 21
    • 0028132050 scopus 로고
    • Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine
    • M. Perez-Reyes, A.R. Jeffcoat, M. Myers, K. Sihler, and C.E. Cook. Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine. Psychopharmacology (Berl). 116: 428-432 (1994).
    • (1994) Psychopharmacology (Berl) , vol.116 , pp. 428-432
    • Perez-Reyes, M.1    Jeffcoat, A.R.2    Myers, M.3    Sihler, K.4    Cook, C.E.5
  • 22
    • 0030839228 scopus 로고    scopus 로고
    • Cocaethylene toxicity
    • P. Andrews. Cocaethylene toxicity. J.Addict Dis. 16: 75-84 (1997).
    • (1997) J.Addict Dis. , vol.16 , pp. 75-84
    • Andrews, P.1
  • 24
    • 0028225826 scopus 로고
    • Simultaneous measurement of cocaine, cocaethylene, their metabolites, and "crack" pyrolysis products by gas chromatography-mass spectrometry
    • E.J. Cone, M. Hillsgrove, and W.D. Darwin. Simultaneous measurement of cocaine, cocaethylene, their metabolites, and "crack" pyrolysis products by gas chromatography-mass spectrometry. Clin. Chem. 40: 1299-1305 (1994).
    • (1994) Clin. Chem. , vol.40 , pp. 1299-1305
    • Cone, E.J.1    Hillsgrove, M.2    Darwin, W.D.3
  • 25
    • 0030982554 scopus 로고    scopus 로고
    • Identification of unique cocaine metabolites and smoking by-products in postmortem blood and urine specimens
    • A.J. Jenkins and B.A. Goldberger. Identification of unique cocaine metabolites and smoking by-products in postmortem blood and urine specimens. J. Forensic Sci. 42: 824-827 (1997).
    • (1997) J. Forensic Sci. , vol.42 , pp. 824-827
    • Jenkins, A.J.1    Goldberger, B.A.2
  • 26
    • 0021363142 scopus 로고
    • Ethyl esters of arylhydroxy- and arylhydroxymethoxycocaines in the urines of simultaneous cocaine and ethanol users
    • R.M. Smith. Ethyl esters of arylhydroxy- and arylhydroxymethoxycocaines in the urines of simultaneous cocaine and ethanol users. J. Anal. Toxicol. 8: 38-42 (1984).
    • (1984) J. Anal. Toxicol. , vol.8 , pp. 38-42
    • Smith, R.M.1
  • 27
    • 28444485280 scopus 로고    scopus 로고
    • Concentration profiles of cocaine, pyrolytic methyl ecgonidine and thirteen metabolites in human blood and urine: Determination by gas chromatography-mass spectrometry
    • B.D. Paul, S. Lalani, T. Bosy, A.J. Jacobs, and M.A. Huestis. Concentration profiles of cocaine, pyrolytic methyl ecgonidine and thirteen metabolites in human blood and urine: determination by gas chromatography-mass spectrometry. Biomed. Chromatogr. 19: 677-688 (2005).
    • (2005) Biomed. Chromatogr. , vol.19 , pp. 677-688
    • Paul, B.D.1    Lalani, S.2    Bosy, T.3    Jacobs, A.J.4    Huestis, M.A.5
  • 28
    • 0031697181 scopus 로고    scopus 로고
    • Cocaine and metabolite concentrations in plasma during repeated oral administration: Development of a human laboratory model of chronic cocaine use
    • R.A. Jufer, S.L.Walsh, and E.J. Cone. Cocaine and metabolite concentrations in plasma during repeated oral administration: development of a human laboratory model of chronic cocaine use. J. Anal. Toxicol. 22: 435-444 (1998).
    • (1998) J. Anal. Toxicol. , vol.22 , pp. 435-444
    • Jufer, R.A.1    Walsh, S.L.2    Cone, E.J.3
  • 29
    • 0034874516 scopus 로고    scopus 로고
    • Analysis of cocaine, benzoylecgonine, ecogonine methyl ester, and ecgonine by high-pressure liquid chromatography-API mass spectrometry and application to a short-term degradation study of cocaine in plasma
    • A. Klingmann, G. Skopp, and R. Aderjan. Analysis of cocaine, benzoylecgonine, ecogonine methyl ester, and ecgonine by high-pressure liquid chromatography-API mass spectrometry and application to a short-term degradation study of cocaine in plasma. J. Anal. Toxicol. 25: 425-430 (2001).
    • (2001) J. Anal. Toxicol. , vol.25 , pp. 425-430
    • Klingmann, A.1    Skopp, G.2    Aderjan, R.3
  • 30
    • 0034582509 scopus 로고    scopus 로고
    • Rapid confirmation/quantitation of cocaine and benzoylecgonine in urine utilizing high performance liquid chromatography and tandem mass spectrometry
    • P.M. Jeanville, E.S. Estape, S.R. Needham, and M.J. Cole. Rapid confirmation/quantitation of cocaine and benzoylecgonine in urine utilizing high performance liquid chromatography and tandem mass spectrometry. J. Am. Soc.Mass Spectrom. 11: 257-263 (2000).
    • (2000) J. Am. Soc.Mass Spectrom. , vol.11 , pp. 257-263
    • Jeanville, P.M.1    Estape, E.S.2    Needham, S.R.3    Cole, M.J.4
  • 31
    • 56449097003 scopus 로고    scopus 로고
    • Complete automation of solid-phase extraction with subsequent liquid chromatography-tandem mass spectrometry for the quantification of benzoylecgonine, m-hydroxybenzoylecgonine, p-hydroxybenzoylecgonine, and norbenzoylecgonine in urine - Application to a high-throughput urine analysis laboratory
    • P.P. Robandt, L. J. Reda, and K.L. Klette. Complete automation of solid-phase extraction with subsequent liquid chromatography-tandem mass spectrometry for the quantification of benzoylecgonine, m- hydroxybenzoylecgonine, p-hydroxybenzoylecgonine, and norbenzoylecgonine in urine - application to a high-throughput urine analysis laboratory. J. Anal. Toxicol. 32: 577-585 (2008).
    • (2008) J. Anal. Toxicol. , vol.32 , pp. 577-585
    • Robandt, P.P.1    Reda, L.J.2    Klette, K.L.3
  • 32
    • 0034306518 scopus 로고    scopus 로고
    • Performance of a pentafluorophenylpropyl stationary phase for the electrospray ionization high-performance liquid chromatography- Mass spectrometry-mass spectrometry assay of cocaine and its metabolite ecgonine methyl ester in human urine
    • S.R. Needham, P.M. Jeanville, P.R. Brown, and E.S. Estape. Performance of a pentafluorophenylpropyl stationary phase for the electrospray ionization high-performance liquid chromatography- mass spectrometry-mass spectrometry assay of cocaine and its metabolite ecgonine methyl ester in human urine. J. Chromatogr. B Biomed. Sci. Appl. 748: 77-87 (2000).
    • (2000) J. Chromatogr. B Biomed. Sci. Appl. , vol.748 , pp. 77-87
    • Needham, S.R.1    Jeanville, P.M.2    Brown, P.R.3    Estape, E.S.4
  • 33
    • 53349141608 scopus 로고    scopus 로고
    • Simultaneous analyses of cocaine and its metabolite benzoylecgonine in urine by LC-MS/MS
    • in Chinese
    • Q.R. Sun, P. Xiang, H. Yan, and M. Shen. Simultaneous analyses of cocaine and its metabolite benzoylecgonine in urine by LC-MS/MS. Fa Yi Xue Za Zhi. 24: 268-272 (2008) (in Chinese).
    • (2008) Fa Yi Xue Za Zhi , vol.24 , pp. 268-272
    • Sun, Q.R.1    Xiang, P.2    Yan, H.3    Shen, M.4
  • 34
    • 34548858452 scopus 로고    scopus 로고
    • Simultaneous determination of multiple drugs of abuse and relevant metabolites in urine by LC-MS-MS
    • J. Feng, L. Wang, I. Dai, T. Harmon, and J.T. Bernert. Simultaneous determination of multiple drugs of abuse and relevant metabolites in urine by LC-MS-MS. J. Anal. Toxicol. 31: 359-368 (2007).
    • (2007) J. Anal. Toxicol. , vol.31 , pp. 359-368
    • Feng, J.1    Wang, L.2    Dai, I.3    Harmon, T.4    Bernert, J.T.5
  • 35
    • 34249733725 scopus 로고    scopus 로고
    • Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry
    • S.S. Johansen and H.M. Bhatia. Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 852: 338-344 (2007).
    • (2007) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.852 , pp. 338-344
    • Johansen, S.S.1    Bhatia, H.M.2
  • 37
    • 0037412260 scopus 로고    scopus 로고
    • Use of the terms "recovery" and "apparent recovery" in analytical procedures (IUPAC Recommendations 2002)
    • D.T. Burns, K. Danzer, and A. Townshend. Use of the terms "recovery" and "apparent recovery" in analytical procedures (IUPAC Recommendations 2002). Pure Appl. Chem. 74: 2201-2205 (2002).
    • (2002) Pure Appl. Chem. , vol.74 , pp. 2201-2205
    • Burns, D.T.1    Danzer, K.2    Townshend, A.3
  • 38
    • 0038574979 scopus 로고    scopus 로고
    • Ion suppression in mass spectrometry
    • T.M. Annesley. Ion suppression in mass spectrometry. Clin. Chem. 49: 1041-1044 (2003).
    • (2003) Clin. Chem. , vol.49 , pp. 1041-1044
    • Annesley, T.M.1
  • 39
    • 0034652086 scopus 로고    scopus 로고
    • An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium
    • Y. Xia, P.Wang, M.G. Bartlett, H.M. Solomon, and K.L. Busch. An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium. Anal. Chem. 72: 764-771 (2000).
    • (2000) Anal. Chem. , vol.72 , pp. 764-771
    • Xia, Y.1    Wang, P.2    Bartlett, M.G.3    Solomon, H.M.4    Busch, K.L.5
  • 40
    • 0016841331 scopus 로고
    • Quantitative determination of cocaine and its metabolites benzoylecgonine and ecgonine by gas-liquid chromatography
    • J.I. Javaid, H. Dekirmenjian, E.G. Brunngraber, and J.M. Davis. Quantitative determination of cocaine and its metabolites benzoylecgonine and ecgonine by gas-liquid chromatography. J. Chromatogr. 110: 140-149 (1975).
    • (1975) J. Chromatogr. , vol.110 , pp. 140-149
    • Javaid, J.I.1    Dekirmenjian, H.2    Brunngraber, E.G.3    Davis, J.M.4
  • 42
    • 0017325720 scopus 로고
    • Simultaneous determination of cocaine and benzoyl ecgonine in urine by gas chromatography with on-column alkylation
    • N.C. Jain, D.M. Chinn, R.D. Budd, T.S. Sneath, and W.J. Leung. Simultaneous determination of cocaine and benzoyl ecgonine in urine by gas chromatography with on-column alkylation. J. Forensic Sci. 22: 7-16 (1977).
    • (1977) J. Forensic Sci. , vol.22 , pp. 7-16
    • Jain, N.C.1    Chinn, D.M.2    Budd, R.D.3    Sneath, T.S.4    Leung, W.J.5
  • 43
    • 0017588025 scopus 로고
    • Quantitative determination of benzoylecgonine and cocaine in human biofluids by gas-liquid chromatography
    • M.J. Kogan, K.G. Verebey, A.C. DePace, R.B. Resnick, and S.J. Mule. Quantitative determination of benzoylecgonine and cocaine in human biofluids by gas-liquid chromatography. Anal. Chem. 49: 1965-1969 (1977).
    • (1977) Anal. Chem. , vol.49 , pp. 1965-1969
    • Kogan, M.J.1    Verebey, K.G.2    DePace, A.C.3    Resnick, R.B.4    Mule, S.J.5
  • 44
    • 0017611890 scopus 로고
    • Simultaneous determination of cocaine and benzoylecgonine in urine by gas-liquid chromatography
    • D.L. von Minden and N.A. D'Amato. Simultaneous determination of cocaine and benzoylecgonine in urine by gas-liquid chromatography. Anal. Chem. 49: 1974-1977 (1977).
    • (1977) Anal. Chem. , vol.49 , pp. 1974-1977
    • Von Minden, D.L.1    D'Amato, N.A.2
  • 45
    • 0025641877 scopus 로고
    • Simultaneous detection in urine of cocaine and its main metabolites
    • J. Ortuño, R. de la Torre, J. Segura, and J. Camí. Simultaneous detection in urine of cocaine and its main metabolites. J. Pharm. Biomed. Anal. 8: 911-914 (1990).
    • (1990) J. Pharm. Biomed. Anal. , vol.8 , pp. 911-914
    • Ortuño, J.1    De La Torre, R.2    Segura, J.3    Camí, J.4
  • 46
    • 0023730823 scopus 로고
    • A method for the simultaneous determination of cocaine, benzoylecgonine, and ecgonine methyl ester in blood and urine using GC/EIMS with derivatization to produce high mass molecular ions
    • D.S. Isenschmid, B.S. Levine, and Y.H. Caplan. A method for the simultaneous determination of cocaine, benzoylecgonine, and ecgonine methyl ester in blood and urine using GC/EIMS with derivatization to produce high mass molecular ions. J. Anal. Toxicol. 12: 242-245 (1988).
    • (1988) J. Anal. Toxicol. , vol.12 , pp. 242-245
    • Isenschmid, D.S.1    Levine, B.S.2    Caplan, Y.H.3
  • 47
    • 0026091130 scopus 로고
    • Analysis of cocaine and cocaethylene in blood and tissues by GC-NPD and GC-ion trap mass spectrometry
    • G.W. Hime, W.L. Hearn, S. Rose, and J. Cofino. Analysis of cocaine and cocaethylene in blood and tissues by GC-NPD and GC-ion trap mass spectrometry. J. Anal. Toxicol. 15: 241-245 (1991).
    • (1991) J. Anal. Toxicol. , vol.15 , pp. 241-245
    • Hime, G.W.1    Hearn, W.L.2    Rose, S.3    Cofino, J.4
  • 48
    • 0028673558 scopus 로고
    • Gas chromatography/mass spectrometry for the determination of cocaine and benzoylecgonine over a wide concentration range (< 0.005-5 mg/dL) in postmortem blood
    • M.R. Corburt and E.M. Koves. Gas chromatography/mass spectrometry for the determination of cocaine and benzoylecgonine over a wide concentration range (< 0.005-5 mg/dL) in postmortem blood. J. Forensic Sci. 39: 136-149 (1994).
    • (1994) J. Forensic Sci. , vol.39 , pp. 136-149
    • Corburt, M.R.1    Koves, E.M.2
  • 49
    • 0028959849 scopus 로고
    • Determination of cocaine and its metabolites in human urine by gas chromatography/mass spectrometry after simultaneous use of cocaine and ethanol
    • R. de la Torre, J. Ortuño, M.L. González, M. Farré, J. Camí, and J. Segura. Determination of cocaine and its metabolites in human urine by gas chromatography/mass spectrometry after simultaneous use of cocaine and ethanol. J. Pharm. Biomed. Anal. 13: 305-312 (1995).
    • (1995) J. Pharm. Biomed. Anal. , vol.13 , pp. 305-312
    • De La Torre, R.1    Ortuño, J.2    González, M.L.3    Farré, M.4    Camí, J.5    Segura, J.6
  • 50
    • 0029819421 scopus 로고    scopus 로고
    • Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS
    • D. Smirnow and B.K. Logan. Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS. J. Anal. Toxicol. 20: 463-467 (1996).
    • (1996) J. Anal. Toxicol. , vol.20 , pp. 463-467
    • Smirnow, D.1    Logan, B.K.2
  • 51
    • 0033818588 scopus 로고    scopus 로고
    • A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine in plasma: Detection of norcocaine in plasma after oral administration of cocaine
    • A.C. Spanbauer, D.E. Moody, R.L. Foltz, and S.L. Walsh. A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine in plasma: detection of norcocaine in plasma after oral administration of cocaine. J. Anal. Toxicol. 24: 453-455 (2000).
    • (2000) J. Anal. Toxicol. , vol.24 , pp. 453-455
    • Spanbauer, A.C.1    Moody, D.E.2    Foltz, R.L.3    Walsh, S.L.4
  • 52
    • 0019256141 scopus 로고
    • High-performance liquid chromatographic analysis of cocaine in human plasma
    • A.N. Masoud and D.M. Krupski. High-performance liquid chromatographic analysis of cocaine in human plasma. J. Anal. Toxicol. 4: 305-310 (1980).
    • (1980) J. Anal. Toxicol. , vol.4 , pp. 305-310
    • Masoud, A.N.1    Krupski, D.M.2
  • 53
    • 0026051867 scopus 로고
    • Determination of cocaine, benzoylecgonine and ecgonine methyl ester in plasma by reversed-hase high-performance liquid chromatography
    • R.L. Miller and C.L. DeVane. Determination of cocaine, benzoylecgonine and ecgonine methyl ester in plasma by reversed-hase high-performance liquid chromatography. J. Chromatogr. 570: 412-418 (1991).
    • (1991) J. Chromatogr. , vol.570 , pp. 412-418
    • Miller, R.L.1    DeVane, C.L.2
  • 54
    • 0029016543 scopus 로고
    • Quantitative determination of cocaine, cocaethylene (ethylcocaine), and metabolites in plasma and urine by high-performance liquid chromatography
    • J. Sukbuntherng, A. Walters, H.H. Chow, and M. Mayersohn. Quantitative determination of cocaine, cocaethylene (ethylcocaine), and metabolites in plasma and urine by high-performance liquid chromatography. J. Pharm. Sci. 84: 799-804 (1995).
    • (1995) J. Pharm. Sci. , vol.84 , pp. 799-804
    • Sukbuntherng, J.1    Walters, A.2    Chow, H.H.3    Mayersohn, M.4
  • 55
    • 0031178303 scopus 로고    scopus 로고
    • Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection
    • K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection. J. Chromatogr. Sci. 35: 321-328 (1997).
    • (1997) J. Chromatogr. Sci. , vol.35 , pp. 321-328
    • Clauwaert, K.M.1    Van Bocxlaer, J.F.2    Lambert, W.E.3    De Leenheer, A.P.4
  • 58
    • 0018860927 scopus 로고
    • Impurities and artifacts of illicit cocaine
    • T. Lukaszewski andW. Jeffery. Impurities and artifacts of illicit cocaine. J. Forensic Sci. 25: 499-508 (1980).
    • (1980) J. Forensic Sci. , vol.25 , pp. 499-508
    • Lukaszewski, T.1    Jeffery, W.2
  • 59
    • 0025200969 scopus 로고
    • A pyrolysis product, anhydroecgonine methyl ester (methylecgonidine), is in the urine of cocaine smokers
    • P. Jacob, III, E.R. Lewis, B.A. Elias-Baker, and R.T. Jones. A pyrolysis product, anhydroecgonine methyl ester (methylecgonidine), is in the urine of cocaine smokers. J. Anal. Toxicol. 14: 353-357 (1990).
    • (1990) J. Anal. Toxicol. , vol.14 , pp. 353-357
    • Jacob III, P.1    Lewis, E.R.2    Elias-Baker, B.A.3    Jones, R.T.4
  • 60
    • 0033490795 scopus 로고    scopus 로고
    • Gas chromatographic-mass spectrometric detection of anhydroecgonine methyl ester (methylecgonidine) in human serum as evidence of recent smoking of crack
    • S.W. Toennes, A.S. Fandino, and G. Kauert. Gas chromatographic-mass spectrometric detection of anhydroecgonine methyl ester (methylecgonidine) in human serum as evidence of recent smoking of crack. J. Chromatogr. B Biomed. Sci. Appl. 735: 127-132 (1999).
    • (1999) J. Chromatogr. B Biomed. Sci. Appl. , vol.735 , pp. 127-132
    • Toennes, S.W.1    Fandino, A.S.2    Kauert, G.3
  • 61
    • 0021338468 scopus 로고
    • Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans
    • J. Ambre, M. Fischman, and T.I. Ruo. Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans. J. Anal. Toxicol. 8: 23-25 (1984).
    • (1984) J. Anal. Toxicol. , vol.8 , pp. 23-25
    • Ambre, J.1    Fischman, M.2    Ruo, T.I.3
  • 62
    • 0023763293 scopus 로고
    • Urinary excretion of cocaine, benzoylecgonine, and ecgonine methyl ester in humans
    • J. Ambre, T.I. Ruo, J. Nelson, and S. Belknap. Urinary excretion of cocaine, benzoylecgonine, and ecgonine methyl ester in humans. J. Anal. Toxicol. 12: 301-306 (1988).
    • (1988) J. Anal. Toxicol. , vol.12 , pp. 301-306
    • Ambre, J.1    Ruo, T.I.2    Nelson, J.3    Belknap, S.4
  • 63
    • 0022351370 scopus 로고
    • The urinary excretion of cocaine and metabolites in humans: A kinetic analysis of published data
    • J. Ambre. The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data. J. Anal. Toxicol. 9: 241-245 (1985).
    • (1985) J. Anal. Toxicol. , vol.9 , pp. 241-245
    • Ambre, J.1
  • 64
    • 0027461339 scopus 로고
    • Serial plasma concentrations of cocaethylene, cocaine, and ethanol in trauma victims
    • D.N. Bailey. Serial plasma concentrations of cocaethylene, cocaine, and ethanol in trauma victims. J. Anal. Toxicol. 17: 79-83 (1993).
    • (1993) J. Anal. Toxicol. , vol.17 , pp. 79-83
    • Bailey, D.N.1
  • 66
    • 0027368696 scopus 로고
    • Cocaethylene: Pharmacologic activity and clinical significance
    • P. Jatlow. Cocaethylene: pharmacologic activity and clinical significance. Ther. Drug. Monit. 15: 533-536 (1993).
    • (1993) Ther. Drug. Monit. , vol.15 , pp. 533-536
    • Jatlow, P.1
  • 67
    • 0141682620 scopus 로고    scopus 로고
    • Urine testing for cocaine abuse: Metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results
    • E.J. Cone, A.H. Sampson-Cone,W.D. Darwin, M.A. Huestis, and J.M. Oyler. Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results. J. Anal. Toxicol. 27: 386-401 (2003).
    • (2003) J. Anal. Toxicol. , vol.27 , pp. 386-401
    • Cone, E.J.1    Sampson-Cone, A.H.2    Darwin, W.D.3    Huestis, M.A.4    Oyler, J.M.5


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