C-reactive protein as a marker of serious bacterial infections in hospitalized febrile infants

Acta Paediatrica, International Journal of Paediatrics

Volumn 98, Issue 11, 2009, Pages 1776-1780

  Bilavsky, Efraim ^a,b   Yarden Bilavsky, Havatzelet ^a,b   Ashkenazi, Shai ^a,b   Amir, Jacob ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Bacteremia; C reactive protein; Serious bacterial infection; Urinary track infection; White blood cell count

Indexed keywords

C REACTIVE PROTEIN;

ARTICLE; BACTEREMIA; BACTERIAL INFECTION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; FEVER; GASTROENTERITIS; HOSPITALIZED INFANT; HUMAN; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MENINGITIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SALMONELLA; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; URINARY TRACT INFECTION;

ANALYSIS OF VARIANCE; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; FEVER; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; LEUKOCYTE COUNT; LOGISTIC MODELS; MALE; OBSERVATION; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 70350496144     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2009.01469.x     Document Type: Article

References (30)

1. Pulliam PN, Attia MW, Cronan KM. C-reactive protein in febrile children 1 to 36 months of age with clinically undetectable serious bacterial infection. Paediatrics 2001 108 : 1275 1279.
2. Bachur RG, Harper MB. Predictive model for serious bacterial infections among infants younger than 3 months of age. Paediatrics 2001 108 : 311 316.
3. Hatherill M, Tibby SM, Sykes K, Turner C, Murdoch IA. Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child 1999 81 : 417 421.
4. Baker MD, Bell LM, Avner JR. Outpatient management without antibiotics of fever in selected infants. N Engl J Med 1993 329 : 1437 1441.
5. Baskin MN, O'Rourke EJ, Fleisher GR. Outpatient treatment of febrile infants 28 to 89 days of age with intramuscular administration of ceftriaxone. J Paediatr 1992 120 : 22 7.
6. Jaskiewicz JA, McCarthy CA, Richardson AC, White KC, Fisher DJ, Dagan R, et al. Febrile infants at low risk for serious bacterial infection - an appraisal of the Rochester criteria and implications for management. Febrile Infant Collaborative Study Group. Paediatrics 1994 94 : 390 396.
7. Dagan R, Powell KR, Hall CB, Menegus MA. Identification of infants unlikely to have serious bacterial infection although hospitalized for suspected sepsis. J Paediatr 1985 107 : 855 860.
8. Dagan R, Sofer S, Phillip M, Shachak E. Ambulatory care of febrile infants younger than 2 months of age classified as being at low risk for having serious bacterial infections. J Paediatr 1988 112 : 355 360.
9. Brown L, Shaw T, Wittlake WA. Does leucocytosis identify bacterial infections in febrile neonates presenting to the emergency department? Emerg Med J 2005 22 : 256 259.
10. Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detection of serious bacterial infections. Paediatrics 2008 122 : 701 710.
11. Galetto-Lacour A, Zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral centre. Paediatrics 2003 112 : 1054 1060.
12. Isaacman DJ, Burke BL. Utility of the serum C-reactive protein for detection of occult bacterial infection in children. Arch Paediatr Adolesc Med 2002 156 : 905 909.
13. Lacour AG, Gervaix A, Zamora SA, Vadas L, Lombard PR, Dayer JM, et al. Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identificators of serious bacterial infections in children with fever without localizing signs. Eur J Paediatr 2001 160 : 95 100.
14. Peltola V, Mertsola J, Ruuskanen O. Comparison of total white blood cell count and serum C-reactive protein levels in confirmed bacterial and viral infections. J Paediatr 2006 149 : 721 724.
15. Gendrel D, Raymond J, Coste J, Moulin F, Lorrot M, Guérin S, et al. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Paediatr Infect Dis J 1999 18 : 875 881. (Pubitemid 29487507)
16. Sormunen P, Kallio MJ, Kilpi T, Peltola H. C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. J Paediatr 1999 134 : 725 729.
17. Toikka P, Irjala K, Juvén T, Virkki R, Mertsola J, Leinonen M, et al. Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Paediatr Infect Dis J 2000 19 : 598 602.
18. Berger RM, Berger MY, van Steensel-Moll HA, Dzoljic-Danilovic G, Derksen-Lubsen G. A predictive model to estimate the risk of serious bacterial infections in febrile infants. Eur J Paediatr 1996 155 : 468 473.
19. Putto A, Ruuskanen O, Meurman O, Ekblad H, Korvenranta H, Mertsola J, et al. C reactive protein in the evaluation of febrile illness. Arch Dis Child 1986 61 : 24 9.
20. Bleeker SE, Moons KG, Derksen-Lubsen G, Grobbee DE, Moll HA. Predicting serious bacterial infection in young children with fever without apparent source. Acta Paediatr 2001 90 : 1226 1232.
21. Bleeker SE, Derksen-Lubsen G, Grobbee DE, Donders AR, Moons KG, Moll HA. Validating and updating a prediction rule for serious bacterial infection in patients with fever without source. Acta Paediatr 2007 96 : 100 104.
22. Bennish M, Beem MO, Ormiste V. C-reactive protein and zeta sedimentation ratio as indicators of bacteremia in paediatric patients. J Paediatr 1984 104 : 729 732.
23. Olaciregui I, Hernández U, Muñoz JA, Emparanza JI, Landa JJ. Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. Arch Dis Child 2009 94 : 501 505.
24. Schlager TA. Urinary tract infections in infants and children. Infect Dis Clin North Am 2003 17 : 353 365.
25. Committee on Quality Improvement. Subcommittee on urinary tract infections. Practice parameter: the diagnosis, treatment, and evaluation of the initial UTI in febrile infants and young children. Paediatrics 1999 103 : 843 852.
26. World Health Organization Pneumonia Vaccine Trial Investigators' Group. Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. Geneva : Department of Vaccines and Biologicals, World Health Organization, 2001.
27. Abramson JH. WINPEPI (PEPI-for-Windows): computer programs for epidemiologists. Epidemiol Perspect Innov 2004 1 : 6.
28. Franz AR, Kron M, Pohlandt F, Steinbach G. Comparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants. Paediatr Infect Dis J 1999 18 : 666 671.
29. Berger C, Uehlinger J, Ghelfi D, Blau N, Fanconi S. Comparison of C-reactive protein and white blood cell count with differential in neonates at risk for septicaemia. Eur J Paediatr 1995 154 : 138 144.
30. Pourcyrous M, Bada HS, Korones SB, Baselski V, Wong SP. Significance of serial C-reactive protein responses in neonatal infection and other disorders. Paediatrics 1993 92 : 431 435.