Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of α-melanocyte stimulating hormone

Photochemistry and Photobiology

Volumn 85, Issue 6, 2009, Pages 1434-1439

  Harms, Juergen H ^a   Lautenschlager, Stephan ^b   Minder, Christoph E ^a   Minder, Elisabeth I ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AFAMELANOTIDE; ALPHA INTERMEDIN; DRUG DERIVATIVE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTACT DERMATITIS; DRUG EFFECT; DRUG POTENTIATION; ERYTHROPOIETIC PROTOPORPHYRIA; FEMALE; HUMAN; MALE; MIDDLE AGED; SKIN PIGMENTATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; AGED; ALPHA-MSH; DERMATITIS, PHOTOTOXIC; FEMALE; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; PROTOPORPHYRIA, ERYTHROPOIETIC; SKIN PIGMENTATION; YOUNG ADULT;

EID: 70350493320     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.2009.00595.x     Document Type: Article

References (45)

1. Anderson, K. E., S. Sassa, D. F. Bishop R. J. Desnick (2001) Disorders of heme biosynthesis: X-linked sideroblastic anemia and the porphyrias. In The Metabolic and Molecular Bases of Inherited Disease (Edited by C. R. Scriver, A. L. Beaudet D. Valle pp. 2991 3062. McGraw-Hill, New York.
2. Rufener, E. (1990) Schattenspringen. PhD Thesis, Philosophische Fakultät I, University of Zurich.
3. Mathews- Roth, M. M., M. A. Pathak, T. B. Fitzpatrick, L. C. Harber E. H. Kass (1974) Beta-carotene as an oral photoprotective agent in erythropoietic protoporphyria. JAMA 228, 1004 1008.
4. Mathews-Roth, M. M., B. Rosner, K. Benfell J. E. Roberts (1994) A double-blind study of cysteine photoprotection in erythropoietic protoporphyria. Photodermatol. Photoimmunol. Photomed. 10, 244 248.
5. Minder, E. I., X. Schneider-Yin, J. Steurer L. M. Bachmann (2009) Systematic review of treatment options in erythropoietic protoporphyria. Cell. Mol. Biol. 55, 84 97.
6. Krook, G. B. Haeger-Aronsen (1982) Beta-carotene in the treatment of erythropoietic protoporphyria. A short review. Acta Derm. Venereol. Suppl. (Stockh.) 100, 125 129.
7. Collins, P. J. Ferguson (1977) Narrow-band UVB (TL-01) phototherapy: An effective preventative treatment for the photodermatoses. Br. J. Dermatol. 132, 956 963.
8. Mathews-Roth, M. M., M. A. Pathak, T. B. Fitzpatrick, L. H. Harber E. H. Kass (1977) Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases. Arch. Dermatol. 113, 1229 1232.
9. Krook, G. B. Haeger-Aronsen (1974) Erythrohepatic protoporphyria and its treatment with beta-carotene. Acta Derm. Venereol. 54, 39 44.
10. Nozickova-Novotna, M., Z. Kraus V. Janousek (1969) Spectral skin sensitivity in erythropoietic protoporphyria. Acta Derm. Venereol. 49, 299 303.
11. Thody, A. (1999) Alpha-MSH and the regulation of melanocyte function. Ann. N. Y. Acad. Sci. 885, 217 229.
12. Sawyer, T. K., P. J. Sanfilippo, V. J. Hruby, M. H. Engel, C. B. Heward, J. B. Burnett M. E. Hadley (1980) 4-Norleucine,7-d-phenylalanine-alpha- melanocyte-stimulating hormone: A highly potent alpha-melanotropin with ultralong biological activity. Proc. Natl Acad. Sci. USA 77, 5754 5758.
13. Barnetson, R. S., T. K. Ooi, L. Zhuang, G. M. Halliday, C. M. Reid, P. C. Walker, S. M. Humphrey M. J. Kleinig (2006) [Nle4-D-Phe7]-alpha-melanocyte- stimulating hormone significantly increased pigmentation and decreased UV damage in fair-skinned Caucasian volunteers. J. Invest. Dermatol. 126, 1869 1878.
14. Fitzgerald, L. M., J. L. Fryer, T. Dwyer S. M. Humphrey (2006) Effect of MELANOTAN, [Nle (4), D-Phe (7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles. Peptides 27, 388 394.
15. Catania, A., S. Gatti, G. Colombo J. M. Lipton (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1 29.
16. Rüfenacht, U. B., L. Gouya, X. Schneider-Yin, H. Puy, B. W. Schäfer, R. Aquaron, Y. Nordmann, E. I. Minder J. C. Deybach (1998) Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria. Am. J. Hum. Genet. 62, 1341 1352.
17. Rüfenacht, U. B., X. Schneider-Yin, B. W. Schäfer, S. Taketani, J. C. Deybach E. I. Minder (1998) Rapid molecular diagnosis of erythropoietic protoporphyria among Swiss patients. Clin. Chem. Lab. Med. 36, 763 765.
18. Gouya, L., H. Puy, A. Robreau, M. Bourgeois, J. Lamoril, V. Da Silva, B. Grandchamp J. C. Deybach (2002) The penetrance of dominant erythropoietic protoporphyria is modulated by expression of wildtype FECH. Nat. Genet. 30, 27 28.
19. Holme, S. A., A. V. Anstey, A. Y. Finlay, G. H. Elder M. N. Badminton (2006) Erythropoietic protoporphyria in the UK: Clinical features and effect on quality of life. Br. J. Dermatol. 155, 574 581.
20. Runge, W. C. J. Watson (1962) Experimental production of skin lesions in human cutaneous porphyria. Proc. Soc. Exp. Biol. Med. 109, 809 811.
21. Runge, W. J. R. M. Fusaro (1971) Erythropoietic protoporphyria. IV. The synergistic effect of ultraviolet and infrared radiation and protection against these wavelengths. Acta Derm. Venereol. 51, 55 58.
22. Poh-Fitzpatrick, M. (1989) The "priming phenomenon" in the acute phototoxicity of erythropoietic protoporphyria. J. Am. Acad. Dermatol. 21, 311.
23. Dwyer, T., H. Muller, L. Blizzard, R. Ashbolt G. Phillips (1998) The use of spectrophotometry to estimate melanin density in Caucasians. Cancer Epidemiol. Biomarkers Prev. 7, 203 206.
24. Dwyer, T., L. Blizzard, R. Ashbolt, J. Plumb, M. Berwick J. M. Stankovich (2002) Cutaneous melanin density of Caucasians measured by spectrophotometry and risk of malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin. Am. J. Epidemiol. 155, 614 621.
25. Rossi, E. P. Garcia-Webb (1986) Red cell zinc protoporphyrin and protoporphyrin by HPLC with fluorescence detection. Biomed. Chromatogr. 1, 163 168.
26. Wilcoxon, F. R. Wilcox (1964) Some Rapid Approximate Statistical Procedures, pp. 36 38. Lederle Laboratories, New York. Cited according to L. Sachs (1978) Angewandte Statistik, 5th edn. pp. 426-429.
27. Slominski, A. Z. (2006) Proopiomelanocortin signaling system is operating in mast cells. J. Invest. Dermatol. 126, 1934.
28. Cui, R., H. R. Widlund, E. Feige, J. Y. Lin, D. L. Wilensky, V. E. Igras, J. D'Orazi, C. Y. Fung, C. F. Schanbacher, S. R. Granter D. E. Fisher (2007) Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 128, 853 864.
29. Barsh, G. L. D. Attardi (2007) A healthy tan? N. Engl. J. Med. 356, 2208 2210.
30. Zhu, N., R. Lalla, P. Eves, T. L. Brown, A. King, E. H. Kemp, J. W. Haycock S. MacNeil (2004) Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone. Br. J. Cancer 90, 1457 1463.
31. Kadekaro, A. L., R. Kavanagh, H. Kanto, S. Terzieva, J. Hauser, N. Kobayashi, S. Schwemberger, J. Cornelius, G. Babcock, H. G. Shertzer, G. Scott Z. A. Abdel-Malek (2005) Alpha-melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes. Cancer Res. 65, 4292 4299.
32. Pavey, S. B. Gabrielli (2002) Alpha-melanocyte stimulating hormone potentiates p16-CDKN2A expression in human skin after ultraviolet irradiation. Cancer Res. 62, 875 880.
33. Jiang, J., S. D. Sharma, S. Nakamura, J. Y. Lai, J. L. Fink, V. J. Hruby M. E. Hadley (1995) The melanotropic peptide, [Nle4, D-Phe7] alpha-MSH, stimulates human melanoma tyrosinase activity and inhibits cell proliferation. Pigment Cell Res. 8, 314 323.
34. Dorr, R. T., G. Ertl, N. Levine, C. Brooks, J. L. Bangert, M. B. Powell, S. Humphrey D. S. Alberts (2004) Effects of superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers. Arch. Dermatol. 140, 827 835.
35. Magnus, I. A., A. Jarrett, T. A. Prankerd C. Rimington (1961) Erythropoietic protoporphyria. A new porphyria syndrome with solar urticaria due to protoporphyrinaemia. Lancet 2, 448 451.
36. Bagdonas, S., I. W. MA, V. Iani, R. Rotomskis, P. Juzenas J. Moan (2000) Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: A spectroscopic study. Photochem. Photobiol. 72, 186 192.
37. Anderson, R. R. J. A. Parrish (1981) The optics of human skin. J. Invest. Dermatol. 77, 13 19.
38. Britton, G. (1995) Structure and properties of carotenoids in relation to function. FASEB J. 9, 1551 1558.
39. Mathews-Roth, M. M. (2000) Erythropoietic protoporphyria: Treatment with antioxidants and potential cure with gene therapy. Methods Enzymol. 319, 479 484.
40. Kadekaro, A. L., K. Wakamatsu, S. Ito Z. A. Abdel-Malek (2006) Cutaneous photoprotection and melanoma susceptibility: Reaching beyond melanin content to the frontiers of DNA repair. Front. Biosci. 11, 2157 2173.
41. Bustamante, J., L. Bredeston, G. Malanga J. Mordoh (1993) Role of melanin as a scavenger of active oxygen species. Pigment Cell Res. 6, 348 353.
42. Eves, P. C., S. MacNeil J. W. Haycock (2006) Alpha-melanocyte stimulating hormone, inflammation and human melanoma. Peptides 27, 444 452.
43. Zaynoun, S. T., J. A. A. Hunter, F. J. Darby, P. Zarembski, B. E. Johnson W. Frain-Bell (1977) The treatment of erythropoietic protoporphyria. Experience with beta-carotene. Br. J. Dermatol. 97, 663 668.
44. Mathews-Roth, M. M. (1979) Phototesting as an objective measurement of improvement in erythropoietic protoporphyria. Arch. Dermatol. 115, 1391 1392.
45. Fusaro, R. M. J. A. Johnson (1975) Limited usefulness of artificial light sources. Arch. Dermatol. 111, 394 396.