Balancing Efficacy and Toxicity of Kidney Transplant Immunosuppression

Transplantation Proceedings

Volumn 41, Issue 8, 2009, Pages 3393-3395

  Naesens, M ^a   Lerut, E ^a   Sarwal, M ^b   Van Damme, B ^a   Vanrenterghem, Y ^a   Kuypers, D R J ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS;

ARTICLE; DNA POLYMORPHISM; GENE EXPRESSION; GENOME; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY DONOR; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MICROARRAY ANALYSIS; NEPHROTOXICITY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RISK ASSESSMENT;

ADULT; BIOPSY; CALCINEURIN; CHILD; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; TIME FACTORS; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 70350491834     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.09.017     Document Type: Article

References (10)

1. Chapman J.R., O'Connell P.J., and Nankivell B.J. Chronic renal allograft dysfunction. J Am Soc Nephrol 16 (2005) 3015
2. Naesens M., Kuypers D.R., and Sarwal M. Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 4 (2009) 481
3. Naesens M., Lerut E., Van Damme B., et al. Tacrolimus exposure and evolution of renal allograft histology in the first year after transplantation. Am J Transplant 7 (2007) 2114
4. Naesens M., Kambham N., Concepcion W., et al. The evolution of non-immune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 7 (2007) 2504
5. Halloran P.F., Melk A., and Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 10 (1999) 167
6. Koziolek M.J., Riess R., Geiger H., et al. Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients. Kidney Int 60 (2001) 156
7. Anglicheau D., Pallet N., Rabant M., et al. Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Kidney Int 70 (2006) 1019
8. Hauser I.A., Schaeffeler E., Gauer S., et al. ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. J Am Soc Nephrol 16 (2005) 1501
9. Naesens M., Li L., Ying L., et al. Local complement gene expression in living and pristine deceased donor kidney allografts. J Am Soc Nephrol 20 (2009) 1839
10. Brown K.M., Kondeatis E., Vaughan R.W., et al. Influence of donor C3 allotype on late renal-transplantation outcome. N Engl J Med 354 (2006) 2014