Pretransplant detection of anti-endothelial cell antibodies could predict renal allograft outcome

Experimental and Clinical Transplantation

Volumn 7, Issue 2, 2009, Pages 104-109

  Ismail, Amani M ^a   Badawi, Rasha M ^a   El Agroudy, Amgad E ^a   Mansour, Merveet A ^b  

^a MANSOURA UNIVERSITY   (Egypt)

^b Tanta University   (Egypt)

Author keywords

Acute rejection; Chronic rejection; Kidney transplant; Outcome; Renal allograft

Indexed keywords

BASILIXIMAB; CREATININE; CYCLOSPORIN; DACLIZUMAB; ENDOTHELIAL CELL ANTIBODY; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; THYMOCYTE ANTIBODY; ANTI-ENDOTHELIAL CELL ANTIBODY; AUTOANTIBODY; BIOLOGICAL MARKER;

ACUTE GRAFT REJECTION; ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; ENDOTHELIUM CELL; FEMALE; GRAFT FAILURE; GRAFT SURVIVAL; HIGH RISK PATIENT; HUMAN; KIDNEY ALLOGRAFT REJECTION; KIDNEY FAILURE; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREOPERATIVE EVALUATION; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; BLOOD; CHRONIC KIDNEY FAILURE; FOLLOW UP; GRAFT REJECTION; IMMUNOLOGY; INCIDENCE; KAPLAN MEIER METHOD; MORTALITY; PREDICTION AND FORECASTING; PREOPERATIVE CARE;

ADULT; AUTOANTIBODIES; BIOLOGICAL MARKERS; CREATININE; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; INCIDENCE; KAPLAN-MEIERS ESTIMATE; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; PREDICTIVE VALUE OF TESTS; PREOPERATIVE CARE;

EID: 70350491404     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bordron A, Révélen R, D'Arbonneau F, et al. Functional heterogeneity of anti-endothelial cell antibodies. Clin Exp Immunol. 2001;124(3):492-501. (Pubitemid 32701714)
2. Meroni PL, D'Cruz D, Khamashta M, Youinou P, Hughes GR. Anti-endothelial cell antibodies: only for scientists or for clinicians too? Clin Exp Immunol. 1996;104(2):199-202.
3. Damianovich M, Gilburd B, George J, et al. Pathogenic role of antiendothelial cell antibodies in vasculitis. An idiotypic experimental model. J Immunol. 1996;156(12):4946-4951. (Pubitemid 26174484)
4. Le Bas-Bernardet S, Hourmant M, Coupel S, Bignon JD, Soulillou JP, Charreau B. Non-HLA-type endothelial cell reactive alloantibodies in pre-transplant sera of kidney recipients trigger apoptosis. Am J Transplant. 2003;3(2):167-177. (Pubitemid 36323114)
5. al-Hussein KA, Talbot D, Proud G, Taylor RM, Shenton BK. The clinical significance of post-transplantation non-HLA antibodies in renal transplantation. Transpl Int. 1995;8(3):214-220.
6. Brasile L, Clarke J, Abrams A, Cerilli J. Risk factors in the development of antibodies to vascular endothelial cells. Transplant Proc. 1989;21(1 Pt 1):716-717. (Pubitemid 19118189)
7. Mohanakumar T, Waldrep JC, Phibbs M, Mendez-Picon G, Kaplan AM, Lee HM. Serological characterization of antibodies eluted from chronically rejected human renal allografts. Transplantation. 1981;32(1):61-66. (Pubitemid 11069861)
8. Harmer AW, Haskard D, Koffman CG, Welsh KI. Novel antibodies associated with unexplained loss of renal allografts. Transpl Int. 1990;3(2):66-69. (Pubitemid 20268661)
9. Nakagawa Y, Saito K, Morioka T, Tomita Y, Takahashi K, Oite T. The clinical significance of antibody to vascular endothelial cells after renal transplantation. Clin Transplant. 2002;16 (Suppl 8):51-57. (Pubitemid 41185574)
10. Paul LC, Baldwin WM 3rd, van Es LA. Vascular endothelial alloantigens in renal transplantation. Transplantation. 1985;40(2):117-123.
11. Fredrich R, Toyoda M, Czer LS, et al. The clinical significance of antibodies to human vascular endothelial cells after cardiac transplantation. Transplantation. 1999;67(3):385-391. (Pubitemid 29094008)
12. Abdulkarim AB, Barnes AD, Adu D, Catty D. A study of endothelial cell-lymphocyte responses in human renal transplantation. Clin Transplant. 1999;13(1 Pt 2):113-122. (Pubitemid 29110379)
13. Lucchiari N, Panajotopoulos N, Xu C, et al. Antibodies eluted from acutely rejected renal allografts bind to and activate human endothelial cells. Hum Immunol. 2000;61(5):518-527. (Pubitemid 30238283)
14. Mizutani K, Terasaki P, Bignon JD, et al. Association of kidney transplant failure and antibodies against MICA. Hum Immunol. 2006;67(9):683-691. (Pubitemid 44430109)
15. Yard B, Spruyt-Gerritse M, Claas F, et al. The clinical significance of allospecific antibodies against endothelial cells detected with an antibody-dependent cellular cytotoxicity assay for vascular rejection and graft loss after renal transplantation. Transplantation. 1993;55(6):1287-1293. (Pubitemid 23183239)
16. Shin YS, Yang CW, Ahn HJ, et al. Clinical significance of anti-endothelial cell antibody in renal transplant recipients. Korean J Intern Med. 2001;16(1):24-29.
17. Kooijmans-Coutinho MF, Hermans J, Schrama E, et al. Interstitial rejection, vascular rejection, and diffuse thrombosis of renal allografts. Predisposing factors, histology, immunohistochemistry, and relation to outcome. Transplantation. 1996;61(9):1338-1344.
18. Sumitran-Karuppan S, Tyden G, Reinholt F, Berg U, Moller E. Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells. Transpl Immunol. 1997;5(4):321-327. (Pubitemid 28026578)