Novel evaluation method for densitometric curves of von Willebrand factor multimers and a new parameter (MMW) to describe the degree of multimersation

Thrombosis and Haemostasis

Volumn 102, Issue 2, 2009, Pages 412-417

  Udvardy, Miklós L ^a,b   Szekeres Csiki, Katalin ^a   Hársfalvi, Jolán ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Von Willebrand disease; VWF multimer analysis

Indexed keywords

COLLAGEN; OLIGOMER; RISTOCETIN; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN; BUFFER; MULTIPROTEIN COMPLEX;

ANALYTIC METHOD; ARTICLE; CELL LYSATE; CONTROLLED STUDY; DENSITOMETRY; FUNCTION TEST; HEMOSTASIS; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; VON WILLEBRAND DISEASE; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; EVALUATION; IN VITRO STUDY; METABOLISM; METHODOLOGY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; STATISTICS;

ADAM PROTEINS; BUFFERS; CASE-CONTROL STUDIES; COLLAGEN; DENSITOMETRY; HUMANS; MOLECULAR WEIGHT; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; VON WILLEBRAND DISEASE; VON WILLEBRAND FACTOR;

EID: 70350464416     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-01-0032     Document Type: Article

References (23)

1. Ruggeri ZM. Von Willebrand factor. Curr Opin Hematol 2003; 10: 142-149.
2. Marx I, Christophe OD, Lenting PJ, et al. Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa. Blood 2008; 112: 603-609.
3. Sadler JE. von Willebrand factor: two sides of a coin. J Thromb Haemost 2005; 3: 1702-1709. (Pubitemid 41716556)
4. Luken BM. Extracellular control of VWF multimer size and thiol-disulfide exchange. J Thromb Haemost 2008; 6: 1131-1134.
5. Tsai HM. Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency. Hematol Oncol Clin North Am 2007; 21: 609-632.
6. Sadler JE. A revised classification of von Willebrand disease. For the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1994; 71: 520-525.
7. Sadler JE, Budde U, Eikenboom JC, et al. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. J Thromb Haemost 2006; 4: 2103-2114. (Pubitemid 44403432)
8. Spiel AO, Gilbert JC, Jilma B. von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes. Circulation 2008; 117: 1449-1459.
9. Blann AD. Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years. Thromb Haemost 2006; 95: 49-55.
10. Favaloro EJ, Thom J, Patterson D, et al. Desmopressin therapy to assist the functional identification and characterisation of von Willebrand disease: Differential utility from combining two (VWF:CB and VWF:RCo) von Willebrand factor activity assays? Thromb Res 2009; 123: 862-868.
11. Raines G, Aumann H, Sykes S, et al. Multimeric analysis of von Willebrand factor by molecular sieving electrophoresis in sodium dodecyl sulphate agarose gel. Thromb Res 1990; 60: 201-212.
12. Ruggeri ZM, Zimmerman TS. The complex multimeric composition of factor VIII/von Willebrand factor. Blood 1981; 57: 1140-1143. (Pubitemid 11050823)
13. Smejkal GB, Shainoff JR, Kottke-Marchant KM. Rapid high-resolution electrophoresis of multimeric von Willebrand Factor using a thermopiloted gel apparatus. Electrophoresis 2003; 24: 582-587.
14. Studt JD, Budde U, Schneppenheim R, et al. Quantification and facilitated comparison of von Willebrand factor multimer patterns by densitometry. Am J Clin Pathol 2001; 116: 567-574. (Pubitemid 34450291)
15. Bowen JD, Bowley SJ. Improved visualisation of high-molecular-weight von Willebrand factor multimers. Thromb Haemost 2007; 97: 1051-1052.
16. Krizek DR, Rick ME. A rapid method to visualize von willebrand factor multimers by using agarose gel electrophoresis, immunolocalization and luminographic detection. Thromb Res 2000; 97: 457-462.
17. Weiss DR, Thiel C, Strasser EF, et al. An optimized electrophoresis method for high-resolution imaging of von-Willebrand multimers. Thromb Haemost 2008; 100: 949-951.
18. Budde U, Schneppenheim R, Eikenboom J, et al. Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD). J Thromb Haemost 2008; 6: 762-771.
19. Gerritsen HE, Turecek PL, Schwarz HP, et al. Assay of von Willebrand factor (vWF)-cleaving protease based on decreased collagen binding affinity of degraded vWF: a tool for the diagnosis of thrombotic thrombocytopenic purpura (TTP). Thromb Haemost 1999; 82: 1386-1389.
20. Cejka J. Enzyme immunoassay for factor VIII-related antigen. Clin Chem 1982; 28: 1356-1358.
21. Claus RA, Bockmeyer CL, Budde U, et al. Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. Thromb Haemost 2009; 101: 239-247.
22. Lopes AA, Soares RP, Maeda NY. A mathematical framework for group analysis of von Willebrand factor multimeric composition following luminography. Braz J.Med Biol Res 2002; 35: 1259-1263.
23. Mazurier C, Dieval J, Jorieux S, et al. A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction. Blood 1990; 75: 20-26.