Cargo binding induces dimerization of myosin VI

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 41, 2009, Pages 17320-17324

  Phichith, Denis ^a   Travaglia, Mirko ^a,b   Yang, Zhaohui ^a   Liu, Xiaoyan ^a   Zong, Alan B ^a   Safer, Daniel ^a   Sweeney, H Lee ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Dab2; Directionality; Motility; Optineurin; Unconventional myosin

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATASE; DIMER; MYOSIN VI; OPTINEURIN; PROTEIN DAB 2; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; DIMERIZATION; ELECTRON MICROSCOPY; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; ANIMALS; BINDING SITES; DIMERIZATION; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MYOSIN HEAVY CHAINS; PROTEIN FOLDING; SURFACE PLASMON RESONANCE; SWINE;

EID: 70350453763     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909748106     Document Type: Article

References (31)

1. Odronitz F, Kollmar M (2007) Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. Genome Biol 8:R196. (Pubitemid 351895469)
2. Wells AL, Lin AW, Chen L-Q, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA Sweeney HL (1999) Myosin VI is an actin-based motor that moves backwards. Nature 401:505-508. (Pubitemid 129515792)
3. Ménétrey J, et al. (2005) The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature 435:779-785. (Pubitemid 40839723)
4. Rock RS, et al. (2005) A flexible domain is essential for the large step size and processivity of myosin VI. Mol Cell 17:603-609.
5. Park H, et al. (2006) Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Mol Cell 21:331-336. (Pubitemid 43163528)
6. Mukherjea M, et al. (2009) Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell 35:305-315.
7. Altman D, Sweeney HL, Spudich JA (2004) The mechanism of myosin VI translocation and its load-induced anchoring. Cell 116:737-749. (Pubitemid 38326731)
8. Buss F, Spudich G, Kendrick-Jones J (2004) Myosin VI: Cellular functions and motor properties. Annu Rev Cell Dev Biol 20:649-676. (Pubitemid 39488653)
9. Frank DJ, Noguchi T, Miller KG (2004) Myosin VI: Cellular functions and motor properties. Curr Opin Cell Biol 16:189-194.
10. Sweeney HL, Houdusse A (2007) What can myosin VI do in cells? Curr Opin Cell Biol 19:57-66.
11. Lister I, et al. (2004) A monomeric myosin VI with a large working stroke. EMBO J 23:1729-1738. (Pubitemid 38649636)
12. Sahlender DA, et al. (2005) Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol 169:285-295.
13. Inoue A, Sato O, Homma K, Ikebe M (2002) DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun 292:300-307.
14. Morris SM, et al. (2002) Myosin VI binds to and localizes with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic 3:331-341.
15. Osterweil E, Wells DG, Mooseker MS (2005) A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168:329-338. (Pubitemid 40248229)
16. Hasson T (2003) Myosin VI: Two distinct roles in endocytosis. J Cell Sci 116:3453-3461.
17. Aschenbrenner L, Naccache SN, Hasson T (2004) Uncoated endocytic vesicles require the unconventional myosin, Myo6, for rapid transport through actin barriers. Mol Biol Cell 15:2253-2263. (Pubitemid 38580643)
18. Spink BJ, Sivaramakrishnan S, Lipfert J, Doniach S, Spudich JA (2008) Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI. Nat Struct Mol Biol 6:591-597. (Pubitemid 351799136)
19. De Marco N, Buono M, Troise F, Diez-Roux G (2006) Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem 281:16147-16156. (Pubitemid 43848510)
20. Sweeney HL, Park H, Zong AB, Yang Z, Selvin PR, Rosenfeld SS (2007) How myosin VI coordinates its heads during processive movement. EMBO J 26:2682-2692. (Pubitemid 46884286)
21. Thorn KS, Ubersax JA, Vale RA (2000) Engineering the processive run length of the kinesin motor. J Cell Biol 151:1093-1100.
22. Hodges AR, Krementsova EB, Trybus KM (2007) Engineering the processive run length of Myosin V. J Biol Chem 282(37):27192-27197.
23. Knight PJ, et al. (2005) The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head. J Biol Chem 280:34702-34708.
24. Sivaramakrishnan S, Spink BJ, Sim AY, Doniach S, Spudich JA (2008) Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif. Proc Natl Acad Sci USA 105:13356-13361.
25. Yu C, et al. (2009) Myosin VI undergoes cargo-mediated dimerization. Cell 138:537-548.
26. Sweeney HL, et al. (1998) Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide-binding pocket. J Biol Chem 273:6262-6270.
27. De La Cruz EM, Ostap EM, Sweeney HL (2001) Kinetic mechanism and regulation of myosin VI. J Biol Chem 276:32373-32381.
28. Yildiz A, Selvin P (2005) Fluorescence imaging with one nanometer accuracy: application to molecular motors. Acc Chem Res 38:574-582. (Pubitemid 41128410)
29. Sbalzarini F, Koumoutsakos P (2005) Feature point tracking and trajectory analysis for video imaging in cell biology. J Struct Biol 151:182-195.
30. Sage D, Neumann F-R, Hediger F, Gasser S-M, Unser M (2005) Automatic tracking of individual fluorescence particles: Application to the study of chromosome dynamics. IEEE Trans Image Process 14:1372-1383. (Pubitemid 41430899)
31. Kerssemakers J-W, et al. (2006) Assembly dynamics of microtubules at molecular resolution. Nature 442:709-712. (Pubitemid 44215328)