APOBEC3 proteins inhibit LINE-1 retrotransposition in the absence of ORF1p binding

Annals of the New York Academy of Sciences

Volumn 1178, Issue , 2009, Pages 268-275

  Lovin, Nika ^a   Peterlin, B Matija ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

APOBEC3; LINE 1; Retrotransposon; Transposable elements

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3A; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3B; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3F; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

CONFERENCE PAPER; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RETROPOSON; RNA INTERFERENCE;

EID: 70350444935     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05006.x     Document Type: Conference Paper

References (35)

1. Lander, E.S. et al. 2001. Initial sequencing and analysis of the human genome. Nature 409: 860-921.
2. Brosius, J. 2003. The contribution of RNAs and retroposition to evolutionary novelties. Genetica 118: 99-116.
3. Feschotte, C. 2008. Transposable elements and the evolution of regulatory networks. Nat. Rev. Genet. 9: 397-405.
4. Belancio, V.P., D.J. Hedges & P. Deininger. 2008. Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health. Genome Res. 18: 343-358.
5. Sassaman, D.M. et al. 1997. Many human L1 elements are capable of retrotransposition. Nat. Genet. 16: 37-43.
6. Goodier, J.L. & H.H. Kazazian, Jr. 2008. Retrotransposons revisited: The restraint and rehabilitation of parasites. Cell 135: 23-35.
7. Kordis, D., N. Lovsin & F. Gubensek. 2006. Phylogenomic analysis of the L1 retrotransposons in Deuterostomia. Syst. Biol. 55: 886-901.
8. Walsh, C.P., J.R. Chaillet & T.H. Bestor. 1998. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet. 20: 116-117.
9. Kanellopoulou, C. et al. 2005. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19: 489-501.
10. Esnault, C. et al. 2005. APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses. Nature 433: 430-433.
11. Navaratnam, N. et al. 1993. The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J. Biol. Chem. 268: 20709-20712.
12. Honjo, T. 2002. Does AID need another aid? Nat. Immunol. 3: 800-801.
13. Jarmuz, A. et al. 2002. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics 79: 285-296.
14. Sheehy, A.M. et al. 2002. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418: 646-650.
15. Harris, R.S. et al. 2003. DNA deamination mediates innate immunity to retroviral infection. Cell 113: 803-809.
16. Zheng, Y.H. et al. 2004. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. J. Virol. 78: 6073-6076.
17. Okeoma, C.M. et al. 2007. APOBEC3 inhibitsmouse mammary tumour virus replication in vivo. Nature 445: 927-930.
18. Santiago, M.L. et al. 2008. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321: 1343-1346.
19. Bogerd, H.P. et al. 2006. APOBEC3A and APOBEC3B are potent inhibitors of LTRretrotransposon function in human cells. Nucleic Acids Res. 34: 89-95.
20. Chen, H. et al. 2006. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr. Biol. 16: 480-485.
21. Muckenfuss, H. et al. 2006. APOBEC3 proteins inhibit human LINE-1 retrotransposition. J. Biol. Chem. 281: 22161-22172.
22. Bogerd, H.P. et al. 2006. Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc. Natl. Acad. Sci. USA 103: 8780-8785.
23. Stenglein, M.D. & R.S. Harris. 2006. APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. J. Biol. Chem. 281: 16837-16841.
24. Kinomoto, M. et al. 2007. All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res. 35(9): 2955-2964.
25. Moran, J.V. et al. 1996. High frequency retrotransposition in cultured mammalian cells. Cell 87: 917-927.
26. Alce, T.M. & W. Popik. 2004. APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein. J. Biol. Chem. 279: 34083-34086.
27. Gallois-Montbrun, S. et al. 2007. Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules. J. Virol. 81: 2165-2178.
28. Wichroski, M.J., G.B. Robb & T.M. Rana. 2006. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS. Pathog. 2: e41.
29. Goodier, J.L. et al. 2007. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol. Cell. Biol. 27: 6469-6483.
30. Niewiadomska, A.M. et al. 2007. Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecularmass- complex formation or P-body association. J. Virol. 81: 9577-9583.
31. Hohjoh, H. & M.F. Singer. 1997. Ribonuclease and high salt sensitivity of the ribonucleoprotein complex formed by the human LINE-1 retrotransposon. J. Mol. Biol. 271: 7-12.
32. Kulpa, D.A. & J.V. Moran. 2006. Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nat. Struct .Mol. Biol. 13: 655-660.
33. Goodier, J.L. et al. 2004. A potential role for the nucleolus in L1 retrotransposition. Hum. Mol. Genet. 13: 1041-1048.
34. Feng, Q. et al. 1996. Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell 87: 905-916.
35. Kohoutek, J., D. Blazek & B.M. Peterlin. 2006. Hexim1 sequesters positive transcription elongation factor b fromthe class II transactivator onMHCclass II promoters. Proc. Natl. Acad. Sci. USA 103: 17349-17354.