Synthesis of the 6′-iso analogues of neplanocin A and 5′-homoneplanocin A

Tetrahedron Letters

Volumn 50, Issue 51, 2009, Pages 7156-7158

  Ye, Wei ^a   He, Mingzhu ^a   Schneller, Stewart W ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Carbocyclic nucleosides; Grubbs reaction; Mitsunobu reaction

Indexed keywords

5' HOMONEPLANOCIN A; 6' ISOHOMONEPLANOCIN A; 6' ISONEPLANOCIN A; NEPLANOCIN A; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; OXIDATION;

EID: 70350434301     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.10.016     Document Type: Article

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15. 1H NMR spectroscopy (i.e., Ha of 8β is a singlet while Ha of 8α is multiplet; Hb of 8β is a doublet while Hb of 8α is a triplet).{A figure is presented}
16. A was observed when more than 1 equiv of adenine was used. However, A could be converted to 5 and 6 under the acidic deprotection.{A figure is presented}
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18. Crystallographic data (excluding structure factors) for the structure in this Letter have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC 744708. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, fax: +44 (0)1223 336033 or e-mail: deposit@ccdc.cam.ac.uk.
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