Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis

Fungal Genetics and Biology

Volumn 46, Issue 12, 2009, Pages 919-926

  Almeida, A J ^a   Cunha, C ^a   Carmona, J A ^a   Sampaio Marques, B ^a   Carvalho, A ^a   Malavazi, I ^b   Steensma, H Y ^c   Johnson, D I ^d   Leao C ^a   Logarinho, E ^a   Goldman, G H ^b   Castro, A G ^a   Ludovico, P ^a   Rodrigues, F ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c LEIDEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Cdc42; Dimorphic pathogenic fungus; Multiple budding; Paracoccidioides brasiliensis

Indexed keywords

PROTEIN CDC42;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; FUNGAL MORPHOLOGY; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE EXPRESSION REGULATION; GENE SILENCING; HOST PATHOGEN INTERACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARACOCCIDIOIDES BRASILIENSIS; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELLS, CULTURED; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HOST-PATHOGEN INTERACTIONS; MACROPHAGES; MICE; MICE, INBRED C57BL; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; PHAGOCYTOSIS; RNA, ANTISENSE; VIRULENCE;

FUNGI; PARACOCCIDIOIDES BRASILIENSIS;

EID: 70350408790     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2009.08.004     Document Type: Article

References (45)

1. Almeida A.J., Carmona J.A., Cunha C., Carvalho A., Rappleye C.A., Goldman W.E., et al. Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis. Fungal Genet Biol 44 (2007) 1387-1398
2. Almeida A.J., Martins M., Carmona J.A., Cano L.E., Restrepo A., Leao C., and Rodrigues F. New insights into the cell cycle profile of Paracoccidioides brasiliensis. Fungal Genet. Biol. 43 (2006) 401-409
3. Bassilana M., Blyth J., and Arkowitz R.A. Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans. Eukaryot. Cell 2 (2003) 9-18
4. Beijersbergen A., Dendulkras A., Schilperoort R.A., and Hooykaas P.J.J. Conjugative transfer by the virulence system of Agrobacterium tumefaciens. Science 256 (1992) 1324-1327
5. Borges-Walmsley M.I., Chen D., Shu X., and Walmsley A.R. The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol. 10 (2002) 80-87
6. Boyce K.J., Hynes M.J., and Andrianopoulos A. The CDC42 homolog of the dimorphic fungus Penicillium marneffei is required for correct cell polarization during growth but not development. J. Bacteriol. 183 (2001) 3447-3457
7. Brummer E., Castaneda E., and Restrepo A. Paracoccidioidomycosis: an update. Clin. Microbiol. Rev. 6 (1993) 89-117
8. Brummer E., Restrepo A., Hanson L.H., and Stevens D.A. Virulence of Paracoccidiodes brasiliensis: the influence of in vitro passage and storage. Mycopathologia 109 (1990) 13-17
9. Bundock P., Dulk-Ras A., Beijersbergen A., and Hooykaas P.J. Trans-kingdom T-DNA transfer from Agrobacterium tumefaciens to Saccharomyces cerevisiae. EMBO J. 14 (1995) 3206-3214
10. Caviston J.P., Tcheperegine S.E., and Bi E. Singularity in budding: a role for the evolutionarily conserved small GTPase Cdc42p. Proc. Natl. Acad. Sci. USA 99 (2002) 12185-12190
11. Chen C., Ha Y.S., Min J.Y., Memmott S.D., and Dickman M.B. Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichum trifolii. Eukaryot. Cell 5 (2006) 155-166
12. Cotteret S., and Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol. 3 (2002) 1-8
13. Dulk-Ras A., and Hooykaas P.J. Electroporation of Agrobacterium tumefaciens. Methods Mol. Biol. 55 (1995) 63-72
14. Etienne-Manneville S. Cdc42 - the centre of polarity. J. Cell Sci. 117 (2004) 1291-1300
15. Ferreira I.D., Rosario V.E., and Cravo P.V. Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum. Malar J. 5 (2006) 1
16. Gietz R.D., and Woods R.A. Yeast transformation by the LiAc/SS carrier DNA/PEG method. Methods Mol. Biol. 313 (2006) 107-120
17. Gomez B.L., Nosanchuk J.D., Diez S., Youngchim S., Aisen P., Cano L.E., et al. Detection of melanin-like pigments in the dimorphic fungal pathogen Paracoccidioides brasiliensis in vitro and during infection. Infect. Immun. 69 (2001) 5760-5767
18. Harris S.D., and Momany M. Polarity in filamentous fungi: moving beyond the yeast paradigm. Fungal Genet. Biol. 41 (2004) 391-400
19. Hoyos G.L., McEwen J.G., Brummer E., Castaneda E., Restrepo A., and Stevens D.A. Chronic murine paracoccidioidomycosis: effect of ketoconazole on clearance of Paracoccidioides brasiliensis and immune response. Sabouraudia 22 (1984) 419-426
20. Johnson D.I. Cdc42: an essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol. Mol. Biol. Rev. 63 (1999) 54-105
21. Johnson D.I., and Pringle J.R. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell Biol. 111 (1990) 143-152
22. Kurokawa C.S., Lopes C.R., Sugizaki M.F., Kuramae E.E., Franco M.F., and Peracoli M.T. Virulence profile of ten Paracoccidioides brasiliensis isolates: association with morphologic and genetic patterns. Rev. Inst. Med. Trop. Sao Paulo 47 (2005) 257-262
23. Larionov A., Krause A., and Miller W. A standard curve based method for relative real time PCR data processing. BMC Bioinform. 6 (2005) 62
24. Logarinho E., Rsende T., Torres C., and Bousbaa H. The human spindle assembly checkpoint protein bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Mol. Biol. Cell 19 (2008) 1798-1813
25. Mahlert M., Leveleki L., Hlubek A., Sandrock B., and Bolker M. Rac1 and Cdc42 regulate hyphal growth and cytokinesis in the dimorphic fungus Ustilago maydis. Mol. Microbiol. 59 (2006) 567-578
26. Michel S., Ushinsky S., Klebl B., Leberer E., Thomas D., Whiteway M., and Morschhauser J. Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes. Mol. Microbiol. 46 (2002) 269-280
27. Miller P.J., and Johnson D.I. Characterization of the Saccharomyces cerevisiae cdc42-1ts allele and new temperature-conditional-lethal cdc42 alleles. Yeast 13 (1997) 561-572
28. Nelson W.J. Mum, this bud's for you: where do you want it? Roles for Cdc42 in controlling bud site selection in Saccharomyces cerevisiae. Bioessays 25 (2003) 833-836
29. Oliveira M.S., Fraga A.G., Torrado E., Castro A.G., Pereira J.P., Filho A.L., et al. Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice. Infect. Immun. 73 (2005) 6299-6310
30. Price M.S., Nichols C.B., and Alspaugh J.A. The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect. Immun. 76 (2008) 5729-5737
31. Rappleye C.A., Engle J.T., and Goldman W.E. RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence. Mol. Microbiol. 53 (2004) 153-165
32. Richman T.J., and Johnson D.I. Saccharomyces cerevisiae cdc42p GTPase is involved in preventing the recurrence of bud emergence during the cell cycle. Mol. Cell Biol. 20 (2000) 8548-8559
33. Richman T.J., Sawyer M.M., and Johnson D.I. Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot. Cell 1 (2002) 458-468
34. Richman T.J., Toenjes K.A., Morales S.E., Cole K.C., Wasserman B.T., Taylor C.M., et al. Analysis of cell-cycle specific localization of the Rdi1p RhoGDI and the structural determinants required for Cdc42p membrane localization and clustering at sites of polarized growth. Curr. Genet. 45 (2004) 339-349
35. Rodrigues F., van Hemert M., Steensma H.Y., Corte-Real M., and Leao C. Red fluorescent protein (DsRed) as a reporter in Saccharomyces cerevisiae. J. Bacteriol. 183 (2001) 3791-3794
36. Rolke Y., and Tudzynski P. The small GTPase Rac and the p21-activated kinase Cla4 in Claviceps purpurea: interaction and impact on polarity, development and pathogenicity. Mol. Microbiol. 68 (2008) 405-423
37. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual (1998), Cold Spring Harbor Laboratory Press, New York
38. Scheffer J., Chen C., Heidrich P., Dickman M.B., and Tudzynski P. A CDC42 homologue in Claviceps purpurea is involved in vegetative differentiation and is essential for pathogenicity. Eukaryot. Cell 4 (2005) 1228-1238
39. Svidzinski T.I., Miranda Neto M.H., Santana R.G., Fischman O., and Colombo A.L. Paracoccidioides brasilienses isolates obtained from patients with acute and chronic disease exhibit morphological differences after animal passage. Rev. Inst. Med. Trop. Sao Paulo 41 (1999) 279-283
40. Ushinsky S.C., Harcus D., Ash J., Dignard D., Marcil A., Morchhauser J., et al. CDC42 is required for polarized growth in human pathogen Candida albicans. Eukaryot. Cell 1 (2002) 95-104
41. Van den Berg A.L., Ibrahim A.S., Edwards Jr. J.E., Toenjes K.A., and Johnson D.I. Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans. Eukaryot. Cell 3 (2004) 724-734
42. Villar L.A., and Restrepo A. Virulence of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature. J. Med. Vet. Mycol. 27 (1989) 141-148
43. Virag A., Lee M.P., Si H., and Harris S.D. Regulation of hyphal morphogenesis by cdc42 and rac1 homologues in Aspergillus nidulans. Mol. Microbiol. 66 (2008) 1579-1596
44. Ye X., and Szaniszlo P.J. Expression of a constitutively active Cdc42 homologue promotes development of sclerotic bodies but represses hyphal growth in the zoopathogenic fungus Wangiella (Exophiala) dermatitidis. J. Bacteriol. 182 (2000) 4941-4950
45. Zhengding S., Hongjian L., Yang L., and Feng N. Inhibition of the pathogenically related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors. Chem. Biol. 14 (2007) 1273-1282