Targeted NF-κB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking model

Cellular Immunology

Volumn 260, Issue 1, 2009, Pages 14-20

  Gu, Xiao Yan ^a   Zhou, Lin Fu ^a   Zhang, Ming Shun ^a   Dai, Wen Jing ^a   Chen, Sai Ying ^b   He, Shao Heng ^a   Ji, Xiao Hui ^a   Yin, Kai Sheng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b The 81st Hospital of PLA   (China)

Author keywords

Asthma; Dendritic cell; Monocyte; NF B; Transendothelial trafficking model

Indexed keywords

B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 4; I KAPPA B KINASE;

ADULT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MALE; MILD INTERMITTENT ASTHMA; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; ASTHMA; BIOLOGICAL MODEL; BLOOD; CELL LINEAGE; CONFOCAL MICROSCOPY; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; METABOLISM; WESTERN BLOTTING;

ADULT; ASTHMA; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; I-KAPPA B KINASE; IMMUNE TOLERANCE; INTERLEUKIN-4; MALE; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MONOCYTES; NF-KAPPA B;

EID: 70350399953     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.07.001     Document Type: Article

References (34)

1. Du Q., Zhou L.F., Chen Z., Gu X.Y., Huang M., and Yin K.S. Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma. Clin. Exp. Pharmacol. Physiol. 36 (2009) 43-48
2. Vermaelen K., and Pauwels R. Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma. Am. J. Respir. Cell Mol. Biol. 29 (2003) 405-409
3. Upham J.W., Denburg J.A., and O'Byrne P.M. Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects. Clin. Exp. Allergy 32 (2002) 818-823
4. Morel P.A., Feili-Hariri M., Coates P.T., and Thomson A.W. Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin. Exp. Immunol. 133 (2003) 1-10
5. Sanarico N., Ciaramella A., Sacchi A., Bernasconi D., Bossù P., Mariani F., Colizzi V., and Vendetti S. Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response. J. Leukoc. Biol. 80 (2006) 555-562
6. Dauer M., Obermaier B., Herten J., Haerle C., Pohl K., Rothenfusser S., Schnurr M., Endres S., and Eigler A. Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors. J. Immunol. 170 (2003) 4069-4076
7. Randolph G.J., Beaulieu S., Lebecque S., Steinman R.M., and Muller W.A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282 (1998) 480-483
8. Blanco P., Palucka A.K., Gill M., Pascual V., and Banchereau J. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 294 (2001) 1540-1543
9. + T cells in asthma. Allergy 63 (2008) 509-517
10. Yoshimura S., Bondeson J., Foxwell B.M., Brennan F.M., and Feldmann M. Effective antigen presentation by dendritic cells is NF-κB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int. Immunol. 13 (2001) 675-683
11. Vakkila J., Demarco R.A., and Lotze M.T. Coordinate NF-κB and STAT1 activation promotes development of myeloid type 1 dendritic cells. Scand. J. Immunol. 67 (2008) 260-269
12. Tanaka T., Grusby M.J., and Kaisho T. PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit. Nat. Immunol. 8 (2007) 584-591
13. + T cell survival through NF-κB activation. Cell Immunol. 231 (2004) 20-29
14. Bateman E.D., Hurd S.S., Barnes P.J., Bousquet J., Drazen J.M., FitzGerald M., Gibson P., Ohta K., O'Byrne P., Pedersen S.E., Pizzichini E., Sullivan S.D., Wenzel S.E., and Zar H.J. Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J. 31 (2008) 143-178
15. Zhou L.F., Zhang M.S., Yin K.S., Ji Y., Xie W.P., Cui X.F., and Ji X.H. Effects of adenoviral gene transfer of mutated IκBα, a novel inhibitor of NF-κB, on human monocyte-derived dendritic cells. Acta Pharmacol. Sin. 27 (2006) 609-616
16. Muller W.A., Ratti C.M., McDonnell S.L., and Cohn Z.A. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J. Exp. Med. 170 (1989) 399-414
17. Zhou L.F., Yin K.S., Zhu Z.L., Zhu Y., Yao X., Mao H., Xie W.P., and Huang M. Adenovirus-mediated overexpression of novel mutated IκBα inhibits nuclear factor κB activation in endothelial cells. Chin. Med. J. 118 (2005) 1422-1428
18. Zhou L.F., Zhu Y., Cui X.F., Xie W.P., Hu A.H., and Yin K.S. Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen-induced airway hyperresponsiveness and inflammation. Respir. Res. 7 (2006) 146
19. Leonard C., Tormey V., Burke C., and Poulter L.W. Allergen-induced cytokine production in atopic disease and its relationship to disease severity. Am. J. Respir. Cell Mol. Biol. 17 (1997) 368-375
20. Delneste Y., Charbonnier P., Herbault N., Magistrelli G., Caron G., Bonnefoy J.Y., and Jeannin P. Interferon-γ switches monocyte differentiation from dendritic cells to macrophages. Blood 101 (2003) 143-150
21. - dendritic cells are sensitized not anergic to subsequent activation. J. Immunol. 173 (2004) 1671-1680
22. Moore F., Buonocore S., Aksoy E., Ouled-Haddou N., Goriely S., Lazarova E., Paulart F., Heirman C., Vaeremans E., Thielemans K., Goldman M., and Flamand V. An alternative pathway of NF-κB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IκBα. J. Immunol. 178 (2007) 1301-1311
23. + MHC Class II-precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process. J. Immunol. 177 (2006) 2536-2542
24. Carucci J.A., Ignatius R., Wei Y., Cypess A.M., Schaer D.A., Pope M., Steinman R.M., and Mojsov S. Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor. J. Immunol. 164 (2000) 3494-3499
25. + T cell activation and CTL effector function. J. Immunol. 168 (2002) 3786-3792
26. Luscinskas F.W., Kansas G.S., Ding H., Pizcueta P., Schleiffenbaum B.E., Tedder T.F., and Gimbrone Jr. M.A. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of l-selectin, beta 1-integrins, and beta 2-integrins. J. Cell Biol. 125 (1994) 1417-1427
27. Verma I.M. Nuclear factor (NF)-κB proteins: therapeutic targets. Ann. Rheum. Dis. 63 (2004) ii57-ii61
28. + monocytes cultured under serum-free conditions. Blood 99 (2002) 600-608
29. Zhong L., Granelli-Piperno A., Choi Y., and Steinman R.M. Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur. J. Immunol. 29 (1999) 964-972
30. Diao J., Smythe J.A., Smyth C., Rowe P.B., and Alexander I.E. Human PBMC-derived dendritic cells transduced with an adenovirus vector induced cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro. Gene Ther. 6 (1999) 845-853
31. + T cells in airway inflammation and tolerance. J. Immunol. 174 (2005) 854-863
32. Dijsselbloem N., Goriely S., Albarani V., Gerlo S., Francoz S., Marine J.C., Goldman M., Haegeman G., and Vanden Berghe W. A critical role for p53 in the control of NF-κB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein. J. Immunol. 178 (2007) 5048-5057
33. Tas S.W., de Jong E.C., Hajji N., May M.J., Ghosh S., Vervoordeldonk M.J., and Tak P.P. Selective inhibition of NF-κB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur. J. Immunol. 35 (2005) 1164-1174
34. Van Scott M.R., Justice J.P., Bradfield J.F., Enright E., Sigounas A., and Sur S. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 278 (2000) 667-674