Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction

Journal of Veterinary Internal Medicine

Volumn 23, Issue 6, 2009, Pages 1247-1253

  Robinson, N E ^a   Berney, C ^a   Behan, A ^a   Derksen, F J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Corticosteroids; Cortisol; Horse; Laminitis

Indexed keywords

ANDROSTANE DERIVATIVE; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; FLUTICASONE;

AEROSOL; ANIMAL; ANIMAL DISEASE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; HORSE; HORSE DISEASE;

AEROSOLS; ANDROSTADIENES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CROSS-OVER STUDIES; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HORSE DISEASES; HORSES; LUNG DISEASES, OBSTRUCTIVE;

ANIMALIA; EQUIDAE;

EID: 70350397282     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0382.x     Document Type: Article

References (23)

1. Baptist AP, Reddy RC. Inhaled corticosteroids for asthma: Are they all the same? J Clin Pharm Ther 2009;34:1-12.
2. Couetil LL, Chilcoat CD, DeNicola DB, et al. Randomized, controlled study of inhaled fluticasone propionate, oral administration of prednisone, and environmental management of horses with recurrent airway obstruction. Am J Vet Res 2005;66:1665-1674.
3. Giguere S, Viel L, Lee E, et al. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet Immunol Immunopathol 2002;85:147-158.
4. Funch-Nielsen H, Roberts C, Weekes J, et al. Evaluation of a new spacer device for delivery of drugs into the equine respiratory system. In: World Equine Airway Symposium, Edinburgh, 2001,56.
5. Derksen FJ, Robinson NE, Armstrong PJ, et al. Airway reactivity in ponies with recurrent airway obstruction (heaves). J Appl Physiol 1985;58:598-604.
6. Robinson NE, Olszewski MA, Boehler D, et al. Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine Vet J 2000;32:393-400.
7. Rush BR, Raub ES, Rhoads WS, et al. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1039-1043.
8. Derksen FJ, Robinson NE. Esophageal and intrapleural pressures in the healthy conscious pony. Am J Vet Res 1980;41:1756-1761.
9. Rooney JT, Roberson JL. The forelimb. In: Equine Pathology. Ames, IA: Iowa State University Press; 1996, 188.
10. Messer NT, Johnson PJ, Refsal KR, et al. Effect of food de-privation on baseline iodothyronine and cortisol concentrations in healthy, adult horses. Am J Vet Res 1995;56:116-121.
11. Robinson NE, Derksen FJ, Olszewski M, et al. Determinants of the maximal change in pleural pressure during tidal breathing in COPD-affected horses. Vet J 1999;157:160-165.
12. Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves). Am J Vet Res 1994;55:885-891.
13. Robinson NE, Jackson C, Jefcoat A, et al. Efficacy of three corticosteroids for the treatment of heaves. Equine Vet J 2002;34:17-22.
14. Cornelisse CJ, Robinson NE, Berney CE, et al. Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction. Equine Vet J 2004;36:426-430.
15. DeLuca L, Erb HN, Young JC, et al. The effect of adding oral dexamethasone to feed alterations on the airway cell inflammatory gene expression in stabled horses affected with recurrent airway obstruction. J Vet intern Med 2008;22:427-435.
16. Couetil LL, Art T, de Moffarts B, et al. Effect of beclomethasone dipropionate and dexamethasone isonicotinate on lung function, bronchoalveolar lavage fluid cytology, and transcription factor expression in airways of horses with recurrent airway obstruction. J Vet Intern Med 2006;20:399-406.
17. Rush BR, Flaminio MJ, Matson CJ, et al. Cytologic evaluation of bronchoalveolar lavage fluid in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1033-1038.
18. Robinson NE, Berney C, Eberhart S, et al. Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction. Am J Vet Res 2003;64:550-557.
19. Lavoie JP, Leguillette R, Pasloske K, et al. Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. Am J Vet Res 2002;63:579-585.
20. Rush BR, Hoskinson JJ, Davis EG, et al. Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction. Am J Vet Res 1999;60: 764-769.
21. Rush BR, Worster AA, Flaminio MJ, et al. Alteration in adrenocortical function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998; 59:1044-1047.
22. Rush BR, Trevino IC, Matson CJ, et al. Serum cortisol concentration in response to incremental doses of inhaled beclomethasone dipropionate. Equine Vet J 1999;31:258-261.
23. Cornelisse CJ, Robinson NE, Berney CA, et al. Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse. Equine Vet J 2006;38:119-126.