Randomized, controlled study of inhaled fluticasone propionate, oral administration of prednisone, and environmental management of horses with recurrent airway obstruction

American Journal of Veterinary Research

Volumn 66, Issue 10, 2005, Pages 1665-1674

  Couëtil, Laurent L ^a   Chilcoat, Clayton D ^a,b   DeNicola, Denis B ^a,c   Clark, Shawn P ^a   Glickman, Nita W ^a   Glickman, Lawrence T ^a  

^a PURDUE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c IDEXX LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE PROPIONATE; GLUCOCORTICOID; HYDROCORTISONE; PREDNISONE; VETERINARY DRUG;

ADRENAL FUNCTION; AIRWAY OBSTRUCTION; ANIMAL CELL; ANIMAL FOOD; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CYTOPATHOLOGY; DISEASE CLASSIFICATION; DISEASE SEVERITY; DUST; ENVIRONMENTAL MANAGEMENT; FEMALE; HORSE DISEASE; HYDROCORTISONE BLOOD LEVEL; LUNG FUNCTION; LUNG LAVAGE; MALE; NONHUMAN; RANDOMIZATION; RECURRENT DISEASE; SCORING SYSTEM; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANDROSTADIENES; ANIMALS; BRONCHOALVEOLAR LAVAGE; ENVIRONMENT; HORSE DISEASES; HORSES; HYDROCORTISONE; PREDNISONE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 27844596766     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1665     Document Type: Article

References (37)

1. Derksen FJ. Chronic obstructive pulmonary disease. In: Beech J, ed. Equine respiratory disorders. Philadelphia: Lea & Febiger, 1991;223-235.
2. Derksen FJ, Scott JS, Miller DC, et al. Bronchoalveolar lavage in ponies with recurrent airway obstruction (heaves). Am Rev Respir Dis 1985;132:1066-1070.
3. McGorum BC, Dixon PM, Halliwell RE. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet J 1993;25:261-267.
4. Gillespie JR, Tyler WS, Eberly VE. Pulmonary ventilation and resistance in emphysematous and control horses. J Appl Physiol 1966;21:416-422.
5. Derksen FJ, Robinson NE, Armstrong PJ, et al. Airway reactivity in ponies with recurrent airway obstruction (heaves). J Appl Physiol 1985;58:598-604.
6. Willoughby RA, McDonnell WN. Pulmonary function testing in horses. Vet Clin North Am Large Anim Pract 1979;1:171-196.
7. Tesarowski DB, Viel L, McDonell WN. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstruction (heaves). Am J Vet Res 1996;57:1214-1219.
8. McPherson EA, Lawson GH, Murphy JR, et al. Chronic obstructive pulmonary disease (COPD): factors influencing the occurrence. Equine Vet J 1979;11:167-171.
9. Tremblay GM, Ferland C, Lapointe JM, et al. Effect of stabling on bronchoalveolar cells obtained from normal and COPD horses. Equine Vet J 1993;25:194-197.
10. Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves). Am J Vet Res 1994;55:885-891.
11. Rush BR, Flaminio MJ, Matson CJ, et al. Cytologic evaluation of bronchoalveolar lavage fluid from horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1033-1038.
12. Robinson NE, Jackson C, Jefcoat A, et al. Efficacy of three corticosteroids for the treatment of heaves. Equine Vet J 2002;34:17-22.
13. Rush BR, Raub ES, Rhoads WS, et al. Pulmonary function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1039-1043.
14. Ammann VJ, Vrins AA, Lavoie J-P. Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD). Equine Vet J 1998;30:152-157.
15. Jackson CA, Berney C, Jefcoat AM, et al. Environment and prednisone interactions in the treatment of recurrent airway obstruction (heaves). Equine Vet J 2000;32:432-438.
16. Peroni DL, Stanley S, Kollias-Baker C, et al. Prednisone per os is likely to have limited efficacy in horses. Equine Vet J 2002;34:283-287.
17. Giguere S, Viel L, Lee E, et al. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet Immunol Immunopathol 2002;85:147-158.
18. Rush BR, Worster AA, Flaminio MJ, et al. Alteration in adrenocortical function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am J Vet Res 1998;59:1044-1047.
19. Lapointe J-M, Lavoie J-P, Vrins AA. Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease. Am J Vet Res 1993;54:1310-1316.
20. Rush BR, Trevino IC, Matson CJ, et al. Serum cortisol concentrations in response to incremental doses of inhaled beclomethasone dipropionate. Equine Vet J 1999;31:258-261.
21. Kelly H. Comparison of inhaled corticosteroids. Ann Pharmacother 1998;32:220-232.
22. Couëtil LL, Rosenthal FS, Simpson CM. Forced expiration: a test for airflow obstruction in horses.J Appl Physiol 2000;88:1870-1879.
23. Couëtil LL, Rosenthal FS, DeNicola DB, et al. Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease. Am J Vet Res 2001;62:538-546.
24. Eiler H, Goble D, Oliver J. Adrenal gland function in the horse: effects of cosyntropin (synthetic) and corticotropin (natural) stimulation. Am J Vet Res 1979;40:724-726.
25. SAS/SAT. The mixed procedure. SAS/SAT user's guide: version 8. Cary NC: SAS Institute Inc, 1999;2083-2226.
26. SAS/SAT. The FREQ procedure. SAS/SAT user's guide: version 8. Cary, NC: SAS Institute Inc, 1999;1245-1362.
27. Derksen FJ, Robinson NE, Scott JS, et al. Aerosolized Micropolyspora faeni antigen as a cause of pulmonary dysfunction in ponies with recurrent airway obstruction (heaves). Am J Vet Res 1988;49:933-938.
28. McPherson EA, Lawson GH, Murphy JR, et al. Chronic obstructive pulmonary disease (COPD) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge. Equine Vet J 1979;11:159-166.
29. Vandenput S, Duvivier DH, Votion D, et al. Environmental control to maintain stabled COPD horses in clinical remission: effects on pulmonary function. Equine Vet J 1998;30:93-96.
30. Rush BR, Hoskinson JJ, Davis EG, et al. Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction. Am J Vet Res 1999;60:764-769.
31. Fairbairn SM, Page CP, Lees P et al. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin Exp Allergy 1993;23:821-828.
32. Grunig G, Hermann M, Howald B, et al. Partial divergence between airway inflammation and clinical signs in equine chronic pulmonary disease. Equine Vet J 1989;21:145-148.
33. Lukacs NW. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 2001;1:108-116.
34. Franchini M, Gill U, von Fellenberg R, et al. Interleukin-8 concentration and neutrophil chemotactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am J Vet Res 2000; 61:1369-1374.
35. Turlej RK, Fievez L, Sandersen CF, et al. Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signaling pathway. Thorax 2001;56:696-702.
36. Martin R, Szefler S, Chinchilli V, et al. Systemic effect comparisons of six inhaled corticosteroids preparations. Am J Respir Crit Care Med 2002;165:1377-1383.
37. Baxter J. Minimizing the side effects of glucocorticoid therapy. Adv Intern Med 1990;35:173-193.