Maintained cerebral metabolic ratio during exercise in patients with β-adrenergic blockade

Clinical Physiology and Functional Imaging

Volumn 29, Issue 6, 2009, Pages 420-426

  Gam, Christiane M B ^a   Rasmussen, Peter ^a   Secher, Niels H ^a   Seifert, Thomas ^a   Larsen, Fin S ^a   Nielsen, Henning B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Brain; Glucose; Lactate; Oxygen

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBOHYDRATE; GLUCOSE; LACTIC ACID; PROPRANOLOL;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ARTERY CATHETER; ARTICLE; BICYCLE ERGOMETRY; BRACHIAL ARTERY; BRAIN METABOLISM; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; EXHAUSTION; FEMALE; HUMAN; INTERNAL JUGULAR VEIN; INTRAVENOUS CATHETER; MALE; MORNING DOSAGE; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; AGED; BRAIN; FEMALE; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; OXYGEN; PHYSICAL ENDURANCE;

EID: 70350396945     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/j.1475-097X.2009.00889.x     Document Type: Article

References (38)

1. Ahlborg G, Juhlin-Dannfelt A. Effect of beta-receptor blockade on splanchnic and muscle metabolism during prolonged exercise in men. J Appl Physiol 1994, 76:1037-1042.
2. Almenoff PL, Leavy J, Weil MH, Goldberg NB, Vega D, Rackow EC. Prolongation of the half-life of lactate after maximal exercise in patients with hepatic dysfunction. Crit Care Med 1989, 17:870-873.
3. Bangsbo J, Juel C, Hellsten Y, Saltin B. Dissociation between lactate and proton exchange in muscle during intense exercise in man. J Physiol 1997, 504:489-499.
4. Biagini MR, Tozzi A, Grippo A, Galli A, Milani S, Amantini A. Muscle fatigue in women with primary biliary cirrhosis: spectral analysis of surface electromyography. World J Gastroenterol 2006, 12:5186-5190.
5. Campillo B, Chapelain C, Bonnet JC, Frisdal E, Devanlay M, Bouissou P, Fouet P, Wirquin E, Atlan G. Hormonal and metabolic changes during exercise in cirrhotic patients. Metabolism 1990a, 39:18-24.
6. Campillo B, Fouet P, Bonnet JC, Atlan G. Submaximal oxygen consumption in liver cirrhosis. Evidence of severe functional aerobic impairment. J Hepatol 1990b, 10:163-167.
7. Clemmesen JO, Kondrup J, Nielsen LB, Larsen FS, Ott P. Effects of high-volume plasmapheresis on ammonia, urea, and amino acids in patients with acute liver failure. Am J Gastroenterol 2001, 96:1217-1223.
8. Cori CF, Cori GT. Glycogen formation in the liver from d- and l-lactic acid. J Biol Chem 1929, 81:389-403.
9. Dalsgaard MK. Fuelling cerebral activity in exercising man. J Cereb Blood Flow Metab 2006, 26:731-750.
10. Dalsgaard MK, Ogoh S, Dawson EA, Yoshiga CC, Quistorff B, Secher NH. Cerebral carbohydrate cost of physical exertion in humans. Am J Physiol Regul Integr Comp Physiol 2004a, 287:R534-R540.
11. Dalsgaard MK, Voliantis S, Yoshiga CC, Dawson EA, Secher NH. Cerebral metabolism during upper and lower body exercise. J Appl Physiol 2004b, 97:1733-1739.
12. Fox PT, Raichle ME, Mintun MA, Dence C. Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988, 241:462-464.
13. Galbo H, Kjaer M, Secher NH. Cardiovascular, ventilatory and catecholamine responses to maximal dynamic exercise in partially curarized man. J Physiol 1987, 389:557-568.
14. Girgrah N, Reid G, MacKenzie S, Wong F. Cirrhotic cardiomyopathy: does it contribute to chronic fatigue and decreased health-related quality of life in cirrhosis?. Can J Gastroenterol 2003, 17:545-551.
15. Ide K, Secher NH. Cerebral blood flow and metabolism during exercise. Prog Neurobiol 2000, 61:397-414.
16. Ide K, Horn A, Secher NH. Cerebral metabolic response to submaximal exercise. J Appl Physiol 1999, 87:1604-1608.
17. Jacobsen EB, Hamberg O, Quistorff B, Ott P. Reduced mitochondrial adenosine triphosphate synthesis in skeletal muscle in patients with Child-Pugh class B and C cirrhosis. Hepatology 2001, 34:7-12.
18. Jørgensen LG. Transcranial Doppler ultrasound for cerebral perfusion. Acta Physiol Scand Suppl 1995, 625:1-44.
19. Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 2002, 288:351-357.
20. Lamperti M, Cortellazzi P, D'Onofrio G, Subert M, Falcone C, Filippini G, Caldiroli D. An outcome study on complications using routine ultrasound assistance for internal jugular vein cannulation. Acta Anaesthesiol Scand 2007, 51:1327-1330.
21. Larsen TS, Rasmussen P, Overgaard M, Secher NH, Nielsen HB. Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans. J Physiol 2008, 586:2807-2815.
22. Madsen PL, Secher NH. Near-infrared oximetry of the brain. Prog Neurobiol 1999, 58:541-560.
23. Madsen PL, Hasselbalch SG, Hagemann LP, Olsen KS, Bulow J, Holm S, Wildschiodtz G, Paulson OB, Lassen NA. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 1995, 15:485-491.
24. Mora-Rodriguez R, Hodgkinson BJ, Byerley LO, Coyle EF. Effects of beta-adrenergic receptor stimulation and blockade on substrate metabolism during submaximal exercise. Am J Physiol Endocrinol Metab 2001, 280:E752-E760.
25. Nielsen B, Nybo L. Cerebral changes during exercise in the heat. Sports Med 2003, 33:1-11.
26. Nielsen HB, Bredmose P, Strømstad M, Volianitis S, Quistorff B, Secher NH. Bicarbonate attenuates arterial desaturation during maximal exercise in humans. J Appl Physiol 2002, 93:724-731.
27. Nielsen HB, Secher NH, Clemmesen JO, Ott P. Maintained cerebral and skeletal muscle oxygenation during maximal exercise in patients with liver cirrhosis. J Hepatol 2005, 43:266-271.
28. Nielsen HB, Febbraio MA, Ott P, Krustrup P, Secher NH. Hepatic lactate uptake versus leg lactate output during exercise in humans. J Appl Physiol 2007, 103:1227-1233.
29. Nybo L, Dalsgaard MK, Steensberg A, Moller K, Secher NH. Cerebral ammonia uptake and accumulation during prolonged exercise in humans. J Physiol 2005, 563:285-290.
30. Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int 2005, 47:13-18.
31. Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 1994, 91:10625-10629.
32. Quistorff B, Secher NH, Van Lieshout JJ. Lactate fuels the human brain during exercise. FASEB J 2008, 22:3443-3449.
33. Schmalbruch IK, Linde R, Paulson OB, Madsen PL. Activation-induced resetting of cerebral metabolism and flow is abolished by beta-adrenergic blockade with propranolol. Stroke 2002, 33:251-255.
34. Selberg O, Radoch E, Walter GF, Muller MJ. Skeletal muscle glycogen content in patients with cirrhosis. Hepatology 1994, 20:135-141.
35. Shulman RG, Hyder F, Rothman DL. Lactate efflux and the neuroenergetic basis of brain function. NMR Biomed 2001, 14:389-396.
36. Strauss GI, Knudsen GM, Kondrup J, Moller K, Larsen FS. Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Gastroenterology 2001, 121:1109-1119.
37. Strauss GI, Moller K, Larsen FS, Kondrup J, Knudsen GM. Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure. Liver Transpl 2003, 9:1244-1252.
38. Volianitis S, Fabricius-Bjerre A, Overgaard A, Stromstad M, Bjarrum M, Carlson C, Petersen NT, Rasmussen P, Secher NH, Nielsen HB. The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans. J Physiol 2008, 586:107-112.