ER export of KAT1 is correlated to the number of acidic residues within a triacidic motif

Traffic

Volumn 10, Issue 10, 2009, Pages 1481-1487

  Mikosch, Melanie ^a   Käberich, Katrin ^a   Homann, Ulrike ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Channel density; Channel trafficking; COPII; ER export; K+ channel; Sec24; Surface expression

Indexed keywords

ASPARTIC ACID; COAT PROTEIN COMPLEX II; GLUTAMIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL; ION CHANNEL;

ACIDITY; ARABIDOPSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN TRANSPORT; SEQUENCE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACIDS, ACIDIC; ARABIDOPSIS; ARABIDOPSIS PROTEINS; ASPARTIC ACID; CELL LINE; CELL MEMBRANE; CONSERVED SEQUENCE; COP-COATED VESICLES; ENDOPLASMIC RETICULUM; GLUTAMIC ACID; HUMANS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION;

EID: 70350393229     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2009.00962.x     Document Type: Article

References (23)

1. Schwappach B. An overview of trafficking and assembly of neurotransmitter receptors and ion channels. Mol Membr Biol 2008, 25:270-278.
2. Otte S, Barlowe C. Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles. Nat Cell Biol 2004, 6:1189-1194.
3. Ma D, Zerangue N, Lin Y, Collins A, Yu M, Jan Y, Jan LY. Role of ER export signals in controlling surface potassium channel numbers. Science 2001, 291:316-319.
4. Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY. Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron 2002, 33:715-729.
5. Hofherr A, Fakler B, Klöcker N. Selective Golgi export of Kir2.1 controls the stoichiometry of functional Kir2.x channel heteromers. J Cell Sci 2005, 118:1935-1943.
6. Zuzarte M, Rinné S, Schlichthörl G, Schubert A, Daut J, Preisig-Müller R. A diacidic sequence motif enhances the surface expression of the potassium channel TASK-3. Traffic 2007, 8:1093-1100.
7. Wang X, Matteson J, An Y, Moyer B, Yoo J, Bannykh S, Wilson IA, Riordan JR, Balch WE. COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a diacidic exit code. J Cell Biol 2004, 167:65-74.
8. Dunkel M, Latz A, Schumacher K, Müller T, Becker D, Hedrich R. Targeting of vacuolar membrane localized members of TPK channel family. Mol Plant 2008, 1:938-949.
9. Mikosch M, Hurst AC, Hertel B, Homann U. Diacidic motif is required for efficient transport of the K+ channel KAT1 to the plasma membrane. J Plant Physiol 2006, 142:923-930.
10. Sieben C, Mikosch M, Brandizzi F, Homann U. Interaction of the K+ channel KAT1 with the COPII coat component Sec24 depends on a diacidic ER export motif. Plant J 2008, 56:997-1006.
11. Mossessova E, Bickford LC, Goldberg J. SNARE selectivity of the COPII coat. Cell 2003, 114:483-495.
12. Miller EA, Beilharz TH, Malkus PN, Lee MCS, Hamamoto S, Orci L, Schekman R. Multiple cargo binding sites on the COPII subunit Sec24 ensure capture of diverse membrane proteins into transport vesicles. Cell 2003, 114:497-509.
13. Pagant S, Kung L, Dorrington M, Lee MCS, Miller EA. Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal. Mol Biol Cell 2007, 18:3398-3413.
14. Hertel B, Horváth F, Wodala B, Hurst A, Moroni A, Thiel G. KAT1 inactivates at submillimolar concentrations of external potassium. J Exp Bot 2005, 56:3103-3110.
15. Szabò I, Negro A, Downey PM, Zoratti M, Lo Schiavo F, Giacometti GM. Temperature-dependent functional expression of a plant K+ channel in mammalian cells. Biochem Biophys Res Commun 2000, 274:130-135.
16. Meckel T, Hurst AC, Thiel G, Homann U. Endocytosis against high turgor: intact guard cells of Vicia faba constitutively endocytose fluorescently labelled plasma membrane and GFP-tagged K+ channel KAT1. Plant J 2004, 39:182-193.
17. Nishimura N, Balch WE. A diacidic signal required for selective export from the endoplasmic reticulum. Science 1997, 277:556-558.
18. Malkus P, Jiang F, Schekman R. Concentrative sorting of secretory cargo proteins into COPII coated vesicles. J Cell Biol 2002, 159:915-921.
19. Nishimura N, Bannykh S, Slabough S, Matteson J, Altschuler Y, Hahn K, Balch WE. A diacidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum. J Biol Chem 1999, 274:15937-15946.
20. Zelazny E, Miecielica U, Borst JW, Hemminga MA, Chaumont F. An N-terminal diacidic motif is required for the trafficking of maize aquaporins ZmPIP2;4 and ZMPIP2:5 to the plasma membrane. Plant J 2009, 57:346-355.
21. Votsmeier C, Gallwitz D. An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export. EMBO J 2001, 20:6742-6750.
22. Pagant S, Kung L, Dorrington M, Lee MCS, Miller EA. Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal. Mol Biol Cell 2007, 18:3398-3413.
23. Hanton SL, Renna L, Bortolotti LE, Chatre L, Stefano G, Brandizzi F. Diacidic motifs influence the export of transmembrane proteins from the endoplasmic reticulum in plant cells. Plant Cell 2005, 17:3081-3093.