Elevation of intracellular cyclic AMP inhibits NF-κB-mediated thymosin β4 expression in melanoma cells

Experimental Cell Research

Volumn 315, Issue 19, 2009, Pages 3325-3335

  Kim, Aeyung ^a   Son, Minsik ^b   Kim, Keun Il ^a   Yang, Young ^a   Song, Eun Young ^c   Lee, Hee Gu ^c   Lim, Jong Seok ^a  

^a Sookmyung Women's University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Cyclic AMP; E cadherin; EMT; Metastasis; MMP; N cadherin; Thymosin 4

Indexed keywords

ACTIN; AGAR; ALPHA INTERMEDIN; CYCLIC AMP; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOBUTYLMETHYLXANTHINE; THYMOSIN BETA4;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL INVASION; CELL MOTILITY; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG RESEARCH; ENZYME ACTIVITY; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MELANOMA; MELANOMA CELL; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ANIMALIA; MURINAE;

EID: 70350370754     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.05.024     Document Type: Article

References (45)

1. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev., Cancer 2 (2002) 442-454
2. Kang Y., and Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118 (2004) 277-279
3. Christofori G., and Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci. 24 (1999) 73-76
4. Hajra K.M., Ji X., and Fearon E.R. Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18 (1999) 7274-7279
5. Wang H.D., Ren J., and Zhang L. CDH1 germline mutation in hereditary gastric carcinoma. World J. Gastroenterol. 10 (2004) 3088-3093
6. Guaita S., Puig I., Franci C., Garrido M., Dominguez D., Batlle E., Sancho E., Dedhar S., De Herreros A.G., and Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J. Biol. Chem. 277 (2002) 39209-39216
7. Hajra K.M., Chen D.Y., and Fearon E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 (2002) 1613-1618
8. Comijn J., Berx G., Vermassen P., Verschueren K., van Grunsven L., Bruyneel E., Mareel M., Huylebroeck D., van Roy F., and The two-handed E. box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7 (2001) 1267-1278
9. Julien S., Puig I., Caretti E., Bonaventure J., Nelles L., van Roy F., Dargemont C., de Herreros A.G., Bellacosa A., and Larue L. Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26 (2007) 7445-7456
10. Grant D.S., Kinsella J.L., Kibbey M.C., LaFlamme S., Burbelo P.D., Goldstein A.L., and Kleinman H.K. Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. J. Cell. Sci. 108 Pt 12 (1995) 3685-3694
11. Malinda K.M., Sidhu G.S., Mani H., Banaudha K., Maheshwari R.K., Goldstein A.L., and Kleinman H.K. Thymosin beta4 accelerates wound healing. J. Invest. Dermatol. 113 (1999) 364-368
12. Clark E.A., Golub T.R., Lander E.S., and Hynes R.O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406 (2000) 532-535
13. Cha H.J., Jeong M.J., and Kleinman H.K. Role of thymosin beta4 in tumor metastasis and angiogenesis. J. Natl. Cancer Inst. 95 (2003) 1674-1680
14. Wang W.S., Chen P.M., Hsiao H.L., Ju S.Y., and Su Y. Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells. Oncogene 22 (2003) 3297-3306
15. Wang W.S., Chen P.M., Hsiao H.L., Wang H.S., Liang W.Y., and Su Y. Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23 (2004) 6666-6671
16. Huang H.C., Hu C.H., Tang M.C., Wang W.S., Chen P.M., and Su Y. Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 26 (2007) 2781-2790
17. Oh S.Y., Song J.H., Gil J.E., Kim J.H., Yeom Y.I., and Moon E.Y. ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance. Exp. Cell Res. 312 (2006) 1651-1657
18. Iguchi K., Usami Y., Hirano K., Hamatake M., Shibata M., and Ishida R. Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs. Biochem. Pharmacol. 57 (1999) 1105-1111
19. Daniel P.B., Walker W.H., Habener J.F., and Cyclic A. signaling and gene regulation. Annu. Rev. Nutr. 18 (1998) 353-383
20. Sunahara R.K., and Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol. Interv. 2 (2002) 168-184
21. Houslay M.D., and Adams D.R. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370 (2003) 1-18
22. Kirschner L.S., Carney J.A., Pack S.D., Taymans S.E., Giatzakis C., Cho Y.S., Cho-Chung Y.S., and Stratakis C.A. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat. Genet. 26 (2000) 89-92
23. Iwasaki T., Chen J.D., Kim J.P., Wynn K.C., and Woodley D.T. Dibutyryl cyclic AMP modulates keratinocyte migration without alteration of integrin expression. J. Invest. Dermatol. 102 (1994) 891-897
24. Tsuruda T., Kato J., Cao Y.N., Hatakeyama K., Masuyama H., Imamura T., Kitamura K., Asada Y., and Eto T. Adrenomedullin induces matrix metalloproteinase-2 activity in rat aortic adventitial fibroblasts. Biochem. Biophys. Res. Commun. 325 (2004) 80-84
25. McCawley L.J., Li S., Benavidez M., Halbleib J., Wattenberg E.V., and Hudson L.G. Elevation of intracellular cAMP inhibits growth factor-mediated matrix metalloproteinase-9 induction and keratinocyte migration. Mol. Pharmacol. 58 (2000) 145-151
26. Murata J., Ayukawa K., Ogasawara M., Fujii H., and Saiki I. Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells. Invasion Metastasis 17 (1997) 82-93
27. Lo H.W., Hsu S.C., Xia W., Cao X., Shih J.Y., Wei Y., Abbruzzese J.L., Hortobagyi G.N., and Hung M.C. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67 (2007) 9066-9076
28. Przybylo J.A., and Radisky D.C. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace. Int. J. Biochem. Cell Biol. 39 (2007) 1082-1088
29. Rees J.R., Onwuegbusi B.A., Save V.E., Alderson D., and Fitzgerald R.C. In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res. 66 (2006) 9583-9590
30. Katerinaki E., Evans G.S., Lorigan P.C., and MacNeil S. TNF-alpha increases human melanoma cell invasion and migration in vitro: the role of proteolytic enzymes. Br. J. Cancer 89 (2003) 1123-1129
31. Lee S.J., Park S.S., Cho Y.H., Park K., Kim E.J., Jung K.H., Kim S.K., Kim W.J., and Moon S.K. Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells: the role of MAP kinase signaling pathways. Oncol. Rep. 19 (2008) 1007-1013
32. Eves P., Haycock J., Layton C., Wagner M., Kemp H., Szabo M., Morandini R., Ghanem G., Garcia-Borron J.C., Jimenez-Cervantes C., and Mac Neil S. Anti-inflammatory and anti-invasive effects of alpha-melanocyte-stimulating hormone in human melanoma cells. Br. J. Cancer 89 (2003) 2004-2015
33. Yoon S.W., Chun J.S., Sung M.H., Kim J.Y., and Poo H. alpha-MSH inhibits TNF-alpha-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells. Osteoarthr. Cartil. 16 (2008) 115-124
34. Rocha A.S., Paternot S., Coulonval K., Dumont J.E., Soares P., Roger P.P., and Cyclic A. inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation. Mol. Biol. Cell 19 (2008) 4814-4825
35. Grbovic O., Jovic V., Ruzdijic S., Pejanovic V., Rakic L., and Kanazir S. 8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis. Cancer Invest. 20 (2002) 972-982
36. Lee C., Lee J., Choi Y.A., Kang S.S., and Baek S.H. cAMP elevating agents suppress secretory phospholipase A(2)-induced matrix metalloproteinase-2 activation. Biochem. Biophys. Res. Commun. 340 (2006) 1278-1283
37. Canton I., Eves P.C., Szabo M., Vidal-Vanaclocha F., Sisley K., Rennie I.G., Haycock J.W., and MacNeil S. Tumor necrosis factor alpha increases and alpha-melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin. J. Invest. Dermatol. 121 (2003) 557-563
38. Hill S.E., Rees R.C., and MacNeil S. A positive association between agonist-induced cyclic AMP production in vitro and metastatic potential in murine B16 melanoma and hamster fibrosarcoma. Clin. Exp. Metastasis 8 (1990) 461-474
39. Eves P.C., MacNeil S., and Haycock J.W. alpha-Melanocyte stimulating hormone, inflammation and human melanoma. Peptides 27 (2006) 444-452
40. Howard E.W., Camm K.D., Wong Y.C., and Wang X.H. E-cadherin upregulation as a therapeutic goal in cancer treatment. Mini Rev. Med. Chem. 8 (2008) 496-518
41. Nummela P., Yin M., Kielosto M., Leaner V., Birrer M.J., and Holtta E. Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts. Cancer Res. 66 (2006) 701-712
42. Goldstein A.L. Thymosin beta4: a new molecular target for antitumor strategies. J. Natl. Cancer Inst. 95 (2003) 1646-1647
43. Parry G.C., and Mackman N. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription. J. Immunol. 159 (1997) 5450-5456
44. Sosne G., Szliter E.A., Barrett R., Kernacki K.A., Kleinman H., and Hazlett L.D. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp. Eye Res. 74 (2002) 293-299
45. Hsiao H.L., Wang W.S., Chen P.M., and Su Y. Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. Carcinogenesis 27 (2006) 936-944