Hiv-specific cd8+ T cell responses to HXB2 Gag and Nef peptide pools in Chinese HIV/AIDS patients

Science in China, Series C: Life Sciences

Volumn 52, Issue 9, 2009, Pages 841-846

  Zhang, HongWei ^a   Qiu, ZhiFeng ^a   Jiao, Yang ^a   Wang, AiXia ^a   Li, Tai Sheng ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

CD8+ T cells; ELISPOT assay; HIV AIDS

Indexed keywords

GAG PROTEIN; NEF PROTEIN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; ASIAN; BLOOD; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CHINA; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ASIAN CONTINENTAL ANCESTRY GROUP; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CHINA; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV LONG-TERM SURVIVORS; HIV-1; HUMANS; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC;

CERCOPITHECINE HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70350365254     PISSN: 10069305     EISSN: 18622798     Source Type: Journal    
DOI: 10.1007/s11427-009-0117-1     Document Type: Article

References (21)

1. Ogg G S, Jin X, Bonhoeffer S, et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science, 1998, 279: 2103-2106.
2. Barouch D H, Santra S, Schmitz J E, et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science, 2000, 290: 486-492.
3. Bernard N F, Yannakis C M, Lee J S, et al. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. J Infect Dis, 1999, 179: 538-547.
4. Rowland-Jones S L, Dong T, Dorrell L, et al. Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly exposed persistently seronegative donors. Immunol Lett, 1999, 66: 9-14.
5. + T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol, 2002, 76: 2298-2305.
6. Keoshkerian E, Ashton L J, Smith D G, et al. Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: Associations with viral replication and progression. J Med Virol, 2003, 71: 483-491.
7. + lymphocytes. Science, 1999, 283: 857-860.
8. Malavika G, Kenneth E U, David B W. DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin Microbiol Rev, 2004, 17: 370-389.
9. Jin X, Ramanathan M Jr, Barsoum S, et al. Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-Infected patients treated with prolonged highly active antiretroviral therapy. J Virol, 2002, 76: 2206-2216.
10. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol, 1994, 68: 6103-6110.
11. Harrer T, Harrer E, Kalams S A, et al. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res Hum Retrovir, 1996, 12: 585-592.
12. Wang Z, Xue X, Zhao F, et al. Gene sequence and subtype analysis of HIV strains in partial area of henan province. J Henan Med Uni, 2006: 4, 1-3.
13. Huang Ch, Ouyang L, Huang J. Detection of HIV infection and analysis of molecular epidemiology in population of blood donors. China J Modern Med, 2006, 16: 3301-3304.
14. Ferrari G, Neal W, Jones A, et al. CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition. Immunol Lett, 2001, 79: 37-45.
15. Fukada K, Tomiyama H, Wasi C, et al. Cytotoxic T-cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thai and Japanese patients. AIDS, 2002, 16: 701-711.
16. Ferrari G, Kostyu D D, Cox J, et al. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res Hum Retroviruses, 2000, 16: 1433-1443.
17. + T Cells: correlation with viral load. J Virol, 2004, 78: 3233-3243.
18. + T cells in HIV-infected progressors and long-term nonprogressors. J Immunol, 2000, 165: 1082-1092.
19. Addo M M, Yu X G, Rathod A, et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-Cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol, 2003, 77: 2081-2092.
20. Zuniga R, Lucchetti A, Galvan P, et al. Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J Virol, 2006, 80: 3122-3125.
21. + T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med, 2007, 13: 46-53.