Progresses in the researches of Alzheimer's disease to reveal the molecular mechanism of disease onset and establish the biochemical diagnostics at early stage

Japanese Journal of Geriatrics

Volumn 46, Issue 5, 2009, Pages 412-415

  Suzuki, Toshiharu ^a   Hata, Saori ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PRESENILIN; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; GENETICS; HUMAN; METABOLISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; HUMANS; MEMBRANE PROTEINS; PRESENILINS;

EID: 70350340846     PISSN: 03009173     EISSN: None     Source Type: Journal    
DOI: 10.3143/geriatrics.46.412     Document Type: Article

References (7)

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2. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, et aL Novel cadherinrelated membrane proteins, Alcadeins, enhance the Xll-like protein-mediated stabilization of amyloid β-protein precursor metabolism. J Biol Chem 2003; 278: 49448-49458.
3. Araki Y. Miyagi N, Kato N, Yoshida T, Wada S. Nishimura M, et al Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65- dependent gene transactivation. J Biol Chem 2004; 279: 24343-24354.
4. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, et aL The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport EMBO J 2007; 26: 1475-1486.
5. Tomita T, Iwatsubo T: γ-secretase as a therapeutic for treatment of Alzheimer's disease. Curr Pharm Des 2006; 12: 661-670.
6. Hata S, Fujishige S, Araki Y, Kato N, Araseki M, et aL Covariant processing of APP and Alcadein by γ- secretase dysfunction and its relation to the sporadic Alzheimer's disease. 2009 Submitted.
7. Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, et al Alcadein metabolite analysis and evidence for mis- processing of multiple γ secretase substrates in Alzheimer's disease. 2009 Submitted.