An in vitro study on antiproliferative and antiestrogenic effects of Boerhaavia diffusa L. extracts

Journal of Ethnopharmacology

Volumn 126, Issue 2, 2009, Pages 221-225

  Sreeja, Sreekumar ^a   Sreeja, Sreeharshan ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

Antiestrogen; Boerhaavia diffusa L.; Breast cancer; Phytoestrogens; Selective estrogen receptor modulators

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALKALOID DERIVATIVE; BOERHAAVIA DIFFUSA EXTRACT; ESTRADIOL; ESTROGEN RECEPTOR; FLAVONOID; HISTONE H3; HYDROXYAPATITE; MESSENGER RNA; METHANOL; PHENOL DERIVATIVE; PLANT MEDICINAL PRODUCT; POLYURONIDE DERIVATIVE; PROTEIN PS2; SAPONIN DERIVATIVE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; FLUORESCENCE ACTIVATED CELL SORTING; HORMONE INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; NYCTAGINACEAE; PHYTOTHERAPY; PLANT EXTRACTS; RECEPTORS, ESTROGEN; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

BOERHAVIA DIFFUSA;

EID: 70350335088     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.041     Document Type: Article

References (31)

1. Bharali R., Azad M.R., and Tabassum J. Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice. Indian Journal of Physiology and Pharmacology 47 (2003) 459-464
2. Brown A.M., Jeltsch J.M., Roberts M., and Chambon P. Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proceedings of the National Academy of Sciences of the United States of America 81 (1984) 6344-6348
3. Canel J.P. Natural products isolation. Methods in Biotechnology 4 (1998) 220-222
4. Cariou S., Donovan J.C., Flanagan W.M., Milic A., Bhattacharya N., and Slingerland J.M. Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 9042-9046
5. Chakraborti K.K., and Handa S.S. Antihepatotoxic activity of Boerhaavia diffusa. Indian drugs 2713 (1989) 161-166
6. Chang C., Yang M., Wen H., and Chern J. Estimation of total flavonoids content in propolis by two complementary colorimetric methods. Journal of Food Drug Analysis 10 (2002) 178-182
7. Cheng G., Weihua Z., Warner M., and Gustafsson J.A. Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 3739-3746
8. Clark J.H., Hardin J.W., and Mc Cormack S.A. Mechanism of action of estrogen agonists and antagonists. Journal of Animal Science 49 (1979) 46-65
9. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. Journal of Immunological Methods 89 (1986) 271-277
10. Ewies A.A. Phytoestrogens in the management of the menopause: up-to-date. Obstetrical and Gynecological Survey 57 (2002) 306-313
11. Finkel E. Phyto-estrogens: the way to postmenopausal health. Lancet 352 (1998) 1762
12. Fotovati A., Fujii T., Yamaguchi M., Kage M., Shirouzu K., Oie S., Basaki Y., Ono M., Yamana H., and Kuwano M. Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells. Clinical Cancer Research 12 (2006) 3010-3018
13. Haridas V., Darnay B.G., Natarajan K., Heller R., and Aggarwal B.B. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation. The Journal of Immunology 160 (1998) 3152-3162
14. Karumi Y., Onnyeyili P.A., and Ogugbuaja V.O. Identification of active principles of of M. balsamina (Balsam Apple) leaf extract. Journal of Medical Sciences 4 (2004) 179-182
15. In: Kirtikar K.R., and Basu B.D. (Eds). Boerhaavia diffusa. Indian Medicinal Plants (1956), Lalit Mohan Basu Publications, Allahabad, India 2045-2048
16. Korach K.S., Davis V.L., Curtis S.W., and Bocchinfuso W.P. Xenoestrogens and estrogen receptor action. Endocrine Toxicology (1997), Taylor & Francis Publications, Bristol, PA pp. 181-211
17. Leslie Taylor N.D. Boerhaavia diffusa. The Healing Power of Rainforest Herbs (2005), Square one Publishers, New York
18. Leyon P.V., Lini C.C., and Kuttan G. Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice. Life Sciences 76 (2005) 1339-1349
19. Lissin L.W., and Cooke J.P. Phytoestrogens and cardiovascular health. Journal of the American College of Cardiology 35 (2000) 1403-1410
20. Manu K.A., and Kuttan G. Effect of Punarnavine, an alkaloid from Boerhaavia diffusa, on cell mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunopharmacology and Immunotoxicology 29 (2007) 569-586
21. Masiakowski P., Breathnach R., Bloch J., Gannon F., Krust A., and Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Research 10 (1982) 7895-7903
22. Mc Donald S., Prenzler P.D., Autolovich M., and Robards K. Phenolic content and antioxidant activity of olive extracts. Food Chemistry 73 (2001) 73-84
23. Mehrotra S., Singh V.K., Agarwal S.S., Maurya R., and Srimal R.C. Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots. Experimental and Molecular Pathology 72 (2002) 236-242
24. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews 52 (2000) 673-751
25. Obong E.E.E., and Madi O.C. Contribution to the cytological effect of medicinal plants: the mitodepressive effect of water extract of Boerhaavia diffusa and Vernonia amygdatina on Allium cepa root tip mitosis. Cytologia 3 (1987) 469-474
26. Papoutsi Z., Kassi E., Fokialakis N., Mitakou S., Lambrinidis G., Mikros E., and Moutsatsou P. Deoxybenzoins are novel potent selective estrogen receptor modulators. Steroids 72 (2007) 693-704
27. Porter W., and Safe S.H. Estrogenic and antiestrogenic compounds. Molecular Biology of the Toxic Response (1999), Taylor & Francis Publications, London pp. 267-279
28. Pratt S.E., and Pollak M.N. Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media. Cancer Research 53 (1993) 5193-5198
29. Sreeja S., and Thampan R. Functional roles of plasma membrane localized estrogen receptors. Indian Journal of Experimental Biology 41 (2003) 740-747
30. Wahi A.K., Agrawal V.K., and Gupta R.C. Phytochemical and pharmacological studies on Boerhaavia diffusa Linn (punarnava) alkaloids. National Academy of Science Letters (1997) 20
31. Zivadinovic D., Gametchu B., and Watson C.S. Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses. Breast Cancer Research 7 (2005) R101-R112