Effect of punarnavine, an alkaloid from Boerhaavia diffusa, on cell-mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice

Immunopharmacology and Immunotoxicology

Volumn 29, Issue 3-4, 2007, Pages 569-586

  Manu, K A ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Antibody Dependent Cellular Cytotoxicity; Antibody Dependent Complement Mediated Cytotoxicity; B16F 10 Punarnavine; Cytokines; Natural Killer Cells

Indexed keywords

ALKALOID DERIVATIVE; BOERHAAVIA DIFFUSA EXTRACT; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; PUNARNAVINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CELL ACTIVITY; CELL DESTRUCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HUMAN; HUMAN CELL; MALE; MELANOMA; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ALKALOIDS; ANIMALS; CELL SURVIVAL; COMPLEMENT SYSTEM PROTEINS; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-1BETA; INTERLEUKIN-2; INTERLEUKIN-6; K562 CELLS; KILLER CELLS, NATURAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NYCTAGINACEAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR NECROSIS FACTOR-ALPHA;

BOERHAVIA DIFFUSA; MUS;

EID: 37149055347     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970701692676     Document Type: Article

References (42)

1. Chrissman, J.D.; Honn, K.V. Applications for metastatic therapies. In Mechanisms of cancer metastasis: Potential therapeutic applications; Honn, R.V.; Powers, W.E.; Solane, B.F.; Eds.; Martinus Nijhoff: Boston, 1986; 399-417.
2. Fidler, I.J. General consideration for studies of experimental metastasis. Meth. Cancer Res. 1978, 15, 399-439.
3. Brittenden, J.; Heys, S.D.; Ross, J.; Enemin, O. Natural killer cells and Cancer. Cancer 1996, 77, 1226-1243
4. Vujanovic, N.L.; Basse, P.; Herberman, R.B.; Whiteside, T.L. Antitumor functions of natural killer cells and control of metastases. Methods 1996, 9, 394-408.
5. Davis, L.; Kutan, G. Immunomodulatory activity of Withania somnifera. J. Ethnopharm. 2000, 71, 193-200.
6. Kuttan, G. Immunomodulatory effect of some naturally occurring sulfur compounds. J. Ethnopharmacol. 2000, 72, 93-99.
7. Thejass, P.; Kuttan, G. Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/C mice by Sulforafane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-γ. Immunopharmacol. Immunotoxicol. 2006, 28, 443-457.
8. Agarwal, R.R.; Dutt, S.S. Chemical examination of Punarnava or Boerhaavia diffusa Linn. II. Isolation of an alkaloid punarnavine. Chem. Abst. 1936, 30, 3585.
9. Basu, N.K.; Lal, S.B.; Sharma, S.N. Investigations on Indian medicinal plants. Quart. J Pharm. Pharmacolol. 1947, 20, 38-42.
10. Surange, S.R.; Pendse, G.S. Pharmacognostic study of roots of Boerhaavia diffusa Willd.(punarnava). J. Res Ind. Med. 1972, 7, 1-5.
11. Sumati, S.; Zafar, R. Genus Boerhaavia. Ind. J. Nat. Prod. 2003, 19, 3-10.
12. Chakraborti, K.K.; Handa, S.S. Antihepatotoxic activity of Boerhaavia diffusa. Ind. Drugs 1989, 2713, 161-166.
13. Chude, M.A.; Orisakwe, O.E.; Affone, O.J.; Gamaniel, K.S.; Vongtau, O.H.; Obi, E. Hypoglycaemic effect of the aqueous extract of Boerhavia diffusa leaves. Lond. J. Pharmacol. 2001, 33, 215-216.
14. Chowdhury, A. Boerhaavia diffusa. Effect on diuresis and some renal enzymes. Ann. Biochem. Exp. Med. 1955, 15, 119-126.
15. Kim, Y.B.; Huh, N.D.; Koren, H.S.; Amos, D.B. Natural Killing (NK) and antibody dependent cellular cytotoxicity(ADCC) in specific pathogen free (SPF) miniature swine and germ free piglets. 1. comparison of NK and ADCC. J. Immunol. 1980, 125, 755-762.
16. Gupta, S.K.; Bhattacharya, B. Cytotoxicity assays. In A Handbook of Practical Immunology. Talwar, G.P., Ed.; Vikas Publishing House: New Delhi, 1983; 328-333.
17. Chomczynski, P.; Sacchi, N. Single-step method for RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162, 156-159.
18. Raulet, D.H.; Vance, R.E.; McMahon, C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 2001, 19, 291-330.
19. Barlozzari, T.; Leonhardt, J.; Wiltrout, R.H.; Herbermann, R.B.; Reynolds, C.W. Direct evidence for the role of LGL in the inhibition of experimental tumor metastases. J. Immunol. 1985; 134, 2783-2789.
20. Aboud, M.; Kingsmore, S.; Segal, S. Role of natural killer cells in controlling local tumor formation and metastatic manifestation of different 3LL Lewis lung carcinoma cell clones. Nat. Immun. 1993, 12, 17-24.
21. Kim, S.; Lizuka, K.; Aguilla, H.L.; Weissmann, I.L.; Yokoyama, W.M. In vivo natural killer cell activities revealed by natural killer cell-deficient mice. Proc. Natl. Acad. Sci. USA 2000, 97, 2731-2736.
22. Smyth, M.J.; Cretney, E.; Takeda, K.; Wiltrout, R.H.; Sedger, L.H.; Layagaki, N.; Yagita, H.; Okumura, K. Tumor necrosis factor related apoptosis inducing ligant (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J. Exp. Med. 2001, 193, 661-670.
23. Lanier, L.L. NK cell receptors. Ann. Rev. Immunol. 1998, 16, 359-393.
24. Ehrhardt, R.O.; Ludviksson, B.R.; Gray, B; Neurath, M; Strober, W. Induction and prevention of chronic inflammation in IL-2 deficient mice. J. Immunol. 1997, 158, 566-573.
25. Misawa, E.; Sakurai, T.; Yamada, M.; Hayasawa, H.; Motoyoshi, K. Effects of macrophage colony-stimulating factor and interleukin-2 administration on NK1.1+ cells in mice. Int. J. Pharmacol. 2000, 22, 967-977.
26. Cailiguiri, M.A.; Murray C.; Robertson, M.J.; Wang, E.; Cochran,K.; Cameron, C.; Schow, P.; Ross, M.E.; Klumpp, T.R.; Soiffer, R.J.; Smith, K.A.; Ritz, J. Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin-2. J. Clin. Invest. 1993, 91, 123-132.
27. Henney, C.S.; Kuribayashi, K.; Kem, D.E.; Gills, S. Interleukin-2 augments natural killer cell activity. Nature 1981, 291, 335-338.
28. Mandelboim, O.; Malik, P.; Davis, D.M.; Jo, C.H.; Boyson, J.E.; Strominger, J.L. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc. Natl. Acad. Sci. USA 1999, 96, 5640-5644.
29. Dolhuis, R. In Natural Cell Mediated Immunity Agaist Tumors; Heben, R.B., Ed.; Academic Press: New York, 1980; 289-291.
30. Koong, A.C.; Denko, N.C.; Hudson, K.M.; Schindler, C.; Swiersz, L.; Koch, C.; Evans, S.; Ibrahim, H.; Le, Q.T.; Terris, D.J.; Giaccia, A.J. Candidate genes for hypoxic tumor phenotype. Cancer Res. 2000, 60, 883-887.
31. Kollias, G.; Douni, E.; Kassiotis, G.; Kontoyiannis, D.; On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunol Rev. 1999, 169, 175-194.
32. Lejeune, F.J.; Ruegge, C.; Lienard, D. Clinical applications of TNF-α in cancer. Curr. Opin. Immunol. 1998, 10, 573-580.
33. Malik, S.T.; Griffin, D.B.; Fiers, W.; Balkwill, F.R. Paradoxical effect of tumor necrosis factor in experimental ovarian cancer. Int. J. Cancer 1989, 44, 918-925.
34. Malik, S.T.; Naylor, M.S.; East, N.; Oliff, A.; Balkwil, F.R. Cells secreting tumor necrosis factor show enhanced metastasis in nude mice. Eur. J. Cancer 1990, 26, 1031-1034.
35. Roberts, R.A.; Kimber, I. Cytokines in non-genotoxic hepatocarcinogenesis. Carcinogenesis 1999, 20, 1397-1401.
36. Burke, F.; Relf, M.; Negus, R.; Balkwill, F. A cytokine profile of normal and malignant ovary. Cytokine 1996, 8, 578-585.
37. Naylor, M.S.; Stamp, G.W.; Faulkes, W.D. Eccles, D.; Balkwill, F.R. Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J. Clin. Invent. 1993, 91, 2194-2206.
38. Vidal-Vanaclocha, F.; Fantuzzi, G.; Mendiza, L. Il-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc. Natl. Acad. Sci. USA 2000, 97, 734-739.
39. Tricot, G.; New insights into role of microenvironment in multiple myeloma. Lancet 2000, 355, 248-250.
40. Bussolino, F.; Ziche, M.; Wang, J.M.; Alessi, D.; Morbidelli, L.; Cremonama, O.; Bosa, A.; Maechisio, P.C.; Mantovani, A. In vitro and in vivo activation of endothelial cells by colony stimulating factors. J. Clin. Invest. 1991, 87, 986-995.
41. Albini, A. Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms. Pathol. Oncol. Res. 1998, 4, 230-241.
42. Jiang, Y.; Goldberg, I.D.; Shi, Y.E. Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 2002, 21, 2245-2252.