Iron-deficiency sensitizes mice to acute pain stimuli and formalin-induced nociception

Journal of Nutrition

Volumn 139, Issue 11, 2009, Pages 2087-2092

  Dowling, Pascal ^a   Klinker, Florian ^a   Amaya, Franco ^a   Paulus, Walter ^a   Liebetanz, David ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CHRONIC PAIN; CONTROLLED STUDY; DIETARY INTAKE; GENE EXPRESSION; HOT PLATE TEST; IMMUNOCOMPETENT CELL; IRON BLOOD LEVEL; IRON DEFICIENCY; MALE; MOUSE; NOCICEPTION; NONHUMAN; ONCOGENE C FOS; PAIN; PAIN THRESHOLD; RESTLESS LEGS SYNDROME; RISK FACTOR; SPINAL CORD; SPINAL CORD DORSAL HORN;

AGING; ANIMALS; ANIMALS, NEWBORN; BIOTINYLATION; DIET; FORMALDEHYDE; GENES, FOS; HOT TEMPERATURE; IMMUNOHISTOCHEMISTRY; IRON; MALE; MICE; MICE, INBRED C57BL; PAIN; PAIN MEASUREMENT; PROTO-ONCOGENE PROTEINS C-FOS; REACTION TIME;

MUS;

EID: 70350330876     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.112557     Document Type: Article

References (41)

1. Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord. 1995;10:634-642
2. Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol. 2001;18:128-147 (Pubitemid 32549908)
3. Ekbom KA. Restless legs syndrome. Neurology. 1960;10:868-873
4. Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep. 1998;21:371-377
5. Earley CJ, Heckler D, Allen RP. The treatment of restless legs syndrome with intravenous iron dextran. Sleep Med. 2004;5:231-235 (Pubitemid 38684216)
6. Baier PC, Ondo WG, Winkelmann J. Animal studies in restless legs syndrome. Mov Disord. 2007;22 Suppl 18:S459-65.
7. Dean T Jr, Allen RP, O'Donnell CP, Earley CJ. The effects of dietary iron deprivation on murine circadian sleep architecture. Sleep Med. 2006;7:634-640
8. Schattschneider J, Bode A, Wasner G, Binder A, Deuschl G, Baron R. Idiopathic restless legs syndrome: abnormalities in central somatosensory processing. J Neurol. 2004;251:977-982 (Pubitemid 39119317)
9. Stiasny-Kolster K, Magerl W, Oertel WH, Moller JC, Treede RD. Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain. 2004;127:773-782 (Pubitemid 38478522)
10. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 1977;4:161-174 (Pubitemid 8234766)
11. Dickenson AH, Sullivan AF. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain. 1987;30:349-360
12. Malmberg AB, Yaksh TL. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther. 1992;263:136-146
13. Heapy CG, Jamieson A, Russel NJW. Afferent C-fiber and A-delta activity in models of inflammation. British Journal of Pharmacology. 1987;90:146.
14. Ishizaki K, Sasaki M, Karasawa S, Obata H, Nara T, Goto F. The effect of intrathecal magnesium sulphate on nociception in rat acute pain models. Anaesthesia. 1999;54:241-246 (Pubitemid 29126974)
15. Shepherd GM. Neurobiology. 3rd ed. New York: Oxford University Press; 1994.
16. Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology. 1992;77:757-763
17. Dorazil-Dudzik M, Mika J, Schafer MK, Li Y, Obara I, Wordliczek J, Przewlocka B. The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw. Anesth Analg. 2004;98:1566-1573 (Pubitemid 38668896)
18. Mendell LM. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp Neurol. 1966;16:316-332
19. Eddy NB, Leimbach D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther. 1953;107:385-393
20. Frolich MA, Price DD, Robinson ME, Shuster JJ, Theriaque DW, Heft MW. The effect of propofol on thermal pain perception. Anesth Analg. 2005;100:481-486 (Pubitemid 40170546)
21. Sanoja R, Cervero F. Estrogen modulation of ovariectomy-induced hyperalgesia in adult mice. Eur J Pain. 2008;12:573-581 (Pubitemid 351615306)
22. Luvisetto S, Marinelli S, Panasiti MS, D'Amato FR, Fletcher CF, Pavone F, Pietrobon D. Pain sensitivity in mice lacking the Ca(v) 2.1alpha1 subunit of P/Q-type Ca2+ channels. Neuroscience. 2006;142:823-832
23. Presley RW, Menetrey D, Levine JD, Basbaum AI. Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci. 1990;10:323-335 (Pubitemid 20059269)
24. Ji RR, Rupp F. Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction. J Neurosci. 1997;17:1776-1785 (Pubitemid 27089822)
25. Stadelmann C, Bruck W, Bancher C, Jellinger K, Lassmann H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol. 1998;57:456-464 (Pubitemid 28237329)
26. Qu S, Le W, Zhang X, Xie W, Zhang A, Ondo WG. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol. 2007;66:383-388 (Pubitemid 46701320)
27. Connor JR, Menzies SL. Cellular management of iron in the brain. J Neurol Sci. 1995;134 Suppl:33-44.
28. Morse AC, Beard JL, Jones BC. A genetic developmental model of iron deficiency: biological aspects. Proc Soc Exp Biol Med. 1999;220:147-152 (Pubitemid 129772904)
29. Zhao H, Zhu W, Pan T, Xie W, Zhang A, Ondo WG, Le W. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res. 2007;85:1065-1076 (Pubitemid 46580347)
30. Yehuda S, Youdim MB. The increased opiate action of beta-endorphin in iron-deficient rats: the possible involvement of dopamine. Eur J Pharmacol. 1984;104:245-251 (Pubitemid 14006361)
31. Li X, Clark JD. Heme oxygenase inhibitors reduce formalin-induced Fos expression in mouse spinal cord tissue. Neuroscience. 2001;105:949-956 (Pubitemid 32786808)
32. Tao YX, Johns RA. Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw. Neuroscience. 2002;112:439-446
33. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci USA. 1999;96:7680-7686 (Pubitemid 29328340)
34. Benarroch EE. Descending monoaminergic pain modulation: bidirectional control and clinical relevance. Neurology. 2008;71:217-221
35. Akpinar S. Treatment of restless legs syndrome with levodopa plus benserazide. Arch Neurol. 1982;39:739.
36. Earley CJ, Allen RP. Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients. Sleep. 1996;19:801-810 (Pubitemid 27131931)
37. Levenson CW, Cutler RG, Ladenheim B, Cadet JL, Hare J, Mattson MP. Role of dietary iron restriction in a mouse model of Parkinson's disease. Exp Neurol. 2004;190:506-514 (Pubitemid 39505004)
38. Yang HW, Zhou LJ, Hu NW, Xin WJ, Liu XG. Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J Neurophysiol. 2005;94:961-967 (Pubitemid 41061337)
39. Liu XG, Sandkuhler J. Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage. Neurosci Lett. 1995;191:43-46
40. Sandkuhler J, Liu X. Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur J Neurosci. 1998;10:2476-2480 (Pubitemid 28302349)
41. Ikeda H, Stark J, Fischer H, Wagner M, Drdla R, Jager T, Sandkuhler J. Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science. 2006;312:1659-1662 (Pubitemid 43902666)