X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens

Journal of Virology

Volumn 83, Issue 21, 2009, Pages 10941-10950

  Hovav, Avi Hai ^a   Santosuosso, Michael ^b   Bivas Benita, Maytal ^c   Plair, Andre ^b   Cheng, Alex ^b   Elnekave, Mazal ^a   Righi, Elda ^b   Chen, Tao ^b   Kashiwagi, Satoshi ^b   Panas, Michael W ^c   Xiang, Shi Hua ^d   Furmanov, Karina ^a   Letvin, Norman L ^c   Poznansky, Mark C ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LUCIFERASE; OVALBUMIN; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION;

AIDS VACCINES; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; APOPTOSIS; FEMALE; HIV ANTIGENS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNIZATION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; OVALBUMIN; PEPTIDE FRAGMENTS; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70350328703     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00394-09     Document Type: Article

References (29)

1. Amara, R. R., J. M. Smith, S. I. Staprans, D. C. Montefiori, F. Villinger, J. D. Altman, S. P. O'Neil, N. L. Kozyr, Y. Xu, L. S. Wyatt, P. L. Earl, J. G. Herndon, J. M. McNicholl, H. M. McClure, B. Moss, and H. L. Robinson. 2002. Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine. J. Virol. 76:6138-6146.
2. Bansal, A., B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert. 2008. Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration. J. Virol. 82:6458-6469. (Pubitemid 351875123)
3. Brainard, D. M., W. G. Tharp, E. Granado, N. Miller, A. K. Trocha, X. H. Ren, B. Conrad, E. F. Terwilliger, R. Wyatt, B. D. Walker, and M. C. Poznansky. 2004. Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J. Virol. 78:5184-5193.
4. Buge, S. L., H. L. Ma, R. R. Amara, L. S. Wyatt, P. L. Earl, F. Villinger, D. C. Montefiori, S. I. Staprans, Y. Xu, E. Carter, S. P. O'Neil, J. G. Herndon, E. Hill, B. Moss, H. L. Robinson, and J. M. McNicholl. 2003. gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge. AIDS Res. Hum. Retrovir. 19:891-900.
5. Donnelly, J. J., B. Wahren, and M. A. Liu. 2005. DNA vaccines: progress and challenges. J. Immunol. 175:633-639.
6. Gao, F., H. X. Liao, B. H. Hahn, N. L. Letvin, B. T. Korber, and B. F. Haynes. 2007. Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr. HIV Res. 5:572-577.
7. Gilbert, S. C., V. S. Moorthy, L. Andrews, A. A. Pathan, S. J. McConkey, J. M. Vuola, S. M. Keating, T. Berthoud, D. Webster, H. McShane, and A. V. Hill. 2006. Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis. Vaccine 24:4554-4561.
8. Gribaudo, G., S. Ravaglia, A. Caliendo, R. Cavallo, M. Gariglio, M. G. Martinotti, and S. Landolfo. 1993. Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription. Virology 197:303-311. (Pubitemid 23313558)
9. + T cells. J. Virol. 81:12793-12802.
10. Iglesias, M. C., K. Mollier, A. S. Beignon, P. Souque, O. Adotevi, F. Lemonnier, and P. Charneau. 2007. Lentiviral vectors encoding HIV-1 polyepitopes induce broad CTL responses in vivo. Mol. Ther. 15:1203-1210.
11. Koller, H., H. Schaal, C. Rosenbaum, M. Czardybon, H. J. Von Giesen, H. W. Muller, and G. Arendt. 2002. Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons. J. Neurovirol. 8:411-419. (Pubitemid 35446711)
12. Letvin, N. L. 2005. Progress toward an HIV vaccine. Annu. Rev. Med. 56:213-223.
13. Liao, H. X., L. L. Sutherland, S. M. Xia, M. E. Brock, R. M. Scearce, S. Vanleeuwen, S. M. Alam, M. McAdams, E. A. Weaver, Z. Camacho, B. J. Ma, Y. Li, J. M. Decker, G. J. Nabel, D. C. Montefiori, B. H. Hahn, B. T. Korber, F. Gao, and B. F. Haynes. 2006. A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology 353:268-282.
14. Lopez, D., Y. Samino, U. H. Koszinowski, and M. Del Val. 2001. HIV envelope protein inhibits MHC class I presentation of a cytomegalovirus protective epitope. J. Immunol. 167:4238-4244. (Pubitemid 32954297)
15. Martinelli, E., C. Cicala, D. Van Ryk, D. J. Goode, K. Macleod, J. Arthos, and A. S. Fauci. 2007. HIV-1 gp120 inhibits TLR9-mediated activation and IFN-α secretion in plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. USA 104:3396-3401.
16. Muller, S., and H. Kohler. 1997. B-cell superantigens in HIV-1 infection. Int. Rev. Immunol. 14:339-349.
17. Musey, L., J. Hughes, T. Schacker, T. Shea, L. Corey, and M. J. McElrath. 1997. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N. Engl. J. Med. 337:1267-1274.
18. Perfettini, J. L., M. Castedo, T. Roumier, K. Andreau, R. Nardacci, M. Piacentini, and G. Kroemer. 2005. Mechanisms of apoptosis induction by the HIV-1 envelope. Cell Death Differ. 12(Suppl. 1):916-923.
19. Prud'homme, G. J. 2005. DNA vaccination against tumors. J. Gene Med. 7:3-17.
20. Ronaldson, P. T., and R. Bendayan. 2006. HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Mol. Pharmacol. 70:1087-1098.
21. + T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. J. Immunol. 169:4951-4960.
22. Santra, S., B. T. Korber, M. Muldoon, D. H. Barouch, G. J. Nabel, F. Gao, B. H. Hahn, B. F. Haynes, and N. L. Letvin. 2008. A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys. Proc. Natl. Acad. Sci. USA 105:10489-10494.
23. Schmidt, B., B. M. Ashlock, H. Foster, S. H. Fujimura, and J. A. Levy. 2005. HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration. Virology 343:256-266. (Pubitemid 41598365)
24. Sellins, K., L. Fradkin, D. Liggitt, and S. Dow. 2005. Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes. Mol. Ther. 12:451-459.
25. Staprans, S. I., A. P. Barry, G. Silvestri, J. T. Safrit, N. Kozyr, B. Sumpter, H. Nguyen, H. McClure, D. Montefiori, J. I. Cohen, and M. B. Feinberg. 2004. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T-cell response to the SIV envelope protein. Proc. Natl. Acad. Sci. USA 101:13026-13031.
26. Stevceva, L., V. Yoon, A. Carville, B. Pacheco, M. Santosuosso, B. Korioth-Schmitz, K. Mansfield, and M. C. Poznansky. 2008. The efficacy of T cellmediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo. J. Immunol. 181:5510-5521.
27. Toapanta, F. R., J. K. Craigo, R. C. Montelaro, and T. M. Ross. 2007. Reduction of anti-HIV-1 Gag immune responses during coimmunization: immune interference by the HIV-1 envelope. Curr. HIV Res. 5:199-209.
28. Tran, P. B., D. Ren, and R. J. Miller. 2005. The HIV-1 coat protein gp120 regulates CXCR4-mediated signaling in neural progenitor cells. J. Neuroimmunol. 160:68-76.
29. Trushin, S. A., A. Algeciras-Schimnich, S. R. Vlahakis, G. D. Bren, S. Warren, D. J. Schnepple, and A. D. Badley. 2007. Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T-cell death that is facilitated by, but does not require cell-associated CD4. J. Immunol. 178:4846-4853.