Vitamin E gel reduces time of healing of digital ulcers in systemic sclerosis

Clinical and Experimental Rheumatology

Volumn 27, Issue 3 SUPPL. 54, 2009, Pages

  Fiori, Ginevra ^a   Galluccio, Felice ^a   Braschi, Francesco ^a   Amanzi, Laura ^a   Miniati, Irene ^a   Conforti, Maria Letizia ^a   Del Rosso, Angela ^a   Generini, Sergio ^a   Candelieri, Antonio ^b   Magonio, Amerigo ^a   Goretti, Roberto ^a   Rasero, Laura ^a   Matucci Cerinic, Marco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Digital ulcers; Systemic sclerosis; Topical medications; Vitamine E

Indexed keywords

ALPHA TOCOPHEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COST OF ILLNESS; DRUG EFFICACY; FEMALE; GEL; HUMAN; MALE; PAIN ASSESSMENT; PRIORITY JOURNAL; SCORING SYSTEM; SKIN ULCER; SYSTEMIC SCLEROSIS; ULCER HEALING;

ADMINISTRATION, TOPICAL; ANTIOXIDANTS; FEMALE; FINGERS; GELS; HUMANS; MALE; MIDDLE AGED; PAIN; PILOT PROJECTS; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; SKIN; SKIN ULCER; VITAMIN E;

EID: 70350306575     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. CLEMENTS PJ, FURST DE (Eds.): Systemic Sclerosis. Baltimore: Williams & Wilkins, 1996.
2. WALKER UA, TYNDALL A, CZIRJAK L et al.: Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann Rheum Dis 2007; 66: 754-763
3. STEEN V, POPE J, DENTON CP, MATUCCI CERINIC M: Digital ulcers: overt vascular disease in systemic sclerosis. Rheumatology 2009; 48 (Suppl. 3): iii 19-24
4. NIHTYANOVA SI, BROUGH GM, BLACK CM, DENTON CP: Clinical burden of digital vasculopathy in limited and diffuse systemic sclerosis. Ann Rheum Dis 2008; 67: 120-123 [Epub 2007, July 27].
5. MALCARNE VL, HANSDOTTIR I, McKINNEY A et al.: Medical signs and symptoms associated with disability, pain, and psychosocial adjustment in systemic sclerosis. J Rheumatol 2007; 34: 359-367
6. MERKEL PA, HERLYN K, MARTIN RW et al.: Scleroderma Clinical Trials Consortium. Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon. Arthritis Rheum 2002; 46: 2410-2420
7. GUIDUCCI S, GIACOMELLI R, MATUCCI CERINIC M: Vascular complication of scleroderma. Autoimmunity Rev 2007; 6: 520-523
8. MATUCCI-CERINIC M, GENERINI S, PIGNONE A, CASALE R: The nervous system in systemic sclerosis (scleroderma). Clinical features and pathogenetic mechanisms. Rheum Dis Clin North Am 1996; 22: 879-892
9. RIEMEKASTEN G, SUNDERKOTTER C: Vasoactive therapies in systemic sclerosis. Rheumatology (Oxford). 2006; 45 (Suppl. 3): iii49-iii51.
10. FIORI G, AMANZI L, MOGGI PIGNONE A, BRASCHI F, MATUCCI-CERINIC M: The treatment of skin ulcers in patients with systemic sclerosis. Reumatismo 2004; 56: 225-234
11. NACHBAR F, KORTING HC: The role of vitamin E in normal and damaged skin. J Mol Med 1995; 73: 7-17.
12. United State Pharmacopeial report (2007). United States Pharmacopeia. www.usp.org.
13. CHOW CK: Vitamin E and oxidative stress. Free Radic Biol Med 1991; 11: 215-232 Review.
14. KAGAN VE, KISIN ER, KAWAI K et al.: Toward mechanism-based antioxidant interventions: lessons from natural antioxidants. Ann N Y Acad Sci 2002; 959: 188-198
15. SMITH CV: Free radical mechanism of tissue injury. In: MOSLEN MT, SMITH CV (Eds.): Free radical mechanism of tissue injury. CRC Boca-Raton, (1992) pp 1-22.
16. DIPLOCK AT, XU G, YEOW C, OKIKIOLA M: Relationship of tocopherol structure to biological activity, tissue uptake and prostaglandin syntesis. Ann N Y Acad Sci 1989; 570: 72-84.
17. TREVITHICK JR, XIONG H, LEE S: Topical tocopherol acetate reduces post UVB sunburn-associated erythema, edema and skin sensitivity in hairless mice. Arch Biochem Biophys 1992; 296: 575-582
18. PANGANAMALA RV, CORNWELL DG: The effects of vitamin E on arachidonic acid metabolism. Ann N Y Acad Sci 1982; 393: 376-91.
19. AYRES S JR, MIHAN R: Is vitamin E involved in the autoimmune mechanism? Cutis 1978; 21: 321-325
20. BURGESS JF, PRITCHARD JE: Tocopherol (vitamin E) therapy in sclerosis of the legs with ulcer. Canad M A J 1948; 59: 242-247
21. MIZUTANI H, YOSHIDA T, NOUCHI N, HAMANAKA H, SHIMIZU M: Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea. J Dermatol 1999; 26: 11-17
22. AYRES S JR, MIHAN R: Lupus erithematosus and Vitamin E: an effective and non toxic therapy. Cutis 1979, 23: 49-52,54.
23. COOK CD, ROSEN FS, BANKER BQ: Dermatomyositis and Focal Scleroderma. Pediatr Clin North Am 1963; 10: 979-1016.
24. AYRES S JR, MIHAN R: Porphyria cutanea tarda: response to vitamin E. A review and two case reports. Cutis 1978; 22: 50-52
25. ERDOǦAN O, ONER A, AYDIN A, ISIMER A, DEMIRCIN G, BÜLBÜL M: Effect of vitamin E treatment on the oxidative damage occurring in Henoch-Schönlein purpura. Acta Paediatr 2003; 92: 546-550
26. HARPER L, NUTTALL SL, MARTIN U, SAVAGE CO: Adjuvant treatment of patients with antineutrophil cytoplasmic antibody-associated vasculitis with vitamins E and C reduces superoxide production by neutrophils. Rheumatology (Oxford). 2002; 41: 274-278
27. LEROY EC, BLACK C, FLEISCHMAJER R et al.: Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202-205
28. AKESSON A, FIORI G, KRIEG T, VAN DER HOOGEN FHJ, SEIBOLD JR: Assessment of skin, joint and muscle involvement. Clin Exp Rheumatol 2003: 21 (Suppl. 29): 55-58
29. VALENTINI G, MATUCCI-CERINIC M: Disease-specific quality indicators, guidelines and outcome measures in scleroderma. Clin Exp Rheumatol 2007; 25 (Suppl. 47): 159-162
30. CLEMENTS P, LACHENBRUCH P, SEIBOLD J et al.: Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995; 22: 1281-1285
31. MATUCCI-CERINIC M, D'ANGELO S, DENTON CP, VLACHOYIANNOPOULOS P, SILVER R: Assessment of lung involvement. Clin Exp Rheumatol 2003; 21 (Suppl. 29): S19-23.
32. EUROPEAN PRESSURE ULCER ADVISORY PANEL: Science and Practice of Pressure Ulcer Management, Springer London 2006.
33. MORELLI S, SGRECCIA A, BERNARDO ML et al.: Systemic sclerosis (scleroderma). A case of recovery of cardiomyopathy after vitamin E treatment. Minerva Cardioangiol 2001; 49: 127-130
34. HARADA M, KUMEMURA H, HARADA R, KOMAI K, SATA M: Scleroderma and repeated spontaneous abortions treated with vitamin E: a case report. Kurume Med J 2005; 52: 93-95
35. HERRICK AL, HOLLIS S, SCHOFIELD D et al.: A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis. Clin Exp Rheumatol 2000; 18: 349-356
36. CRACOWSKI JL, GIROLET S, IMBERT B et al.: Effects of short-term treatment with vitamin E in systemic sclerosis: a double-blind, randomized, controlled clinical trial of efficacy based on urinary isoprostane measurement. Free Radical Biol Med 2005; 38: 98-103.