Adjuvant treatment of patients with antineutrophil cytoplasmic antibody-associated vasculitis with vitamins E and C reduces superoxide production by neutrophils

Rheumatology

Volumn 41, Issue 3, 2002, Pages 274-278

  Harper, L ^a   Nuttall, S L ^a   Martin, U ^a   Savage, C O S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Antioxidant; Neutrophils; Superoxide; Systematic vasculitis; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; AZATHIOPRINE; CARMUSTINE; CYTOCHROME C; GLUCOCORTICOID; NEUTROPHIL CYTOPLASMIC ANTIBODY; PLACEBO; PREDNISOLONE; STEROID; SUPEROXIDE; TROLOX C;

ABDOMINAL CRAMP; ADJUVANT THERAPY; ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; DIARRHEA; DONOR; FEMALE; HUMAN; LEUKOCYTE ACTIVATION; MALE; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY BURST; SYSTEMIC VASCULITIS;

EID: 0036100384     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/41.3.274     Document Type: Article

References (27)

1. Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
2. Reactivity of antineutrophil cytoplasmic antibodies with mononuclear phagocytes
3. Dysregulated neutrophil apoptosis in systemic vasculitis
4. Autoantibodies developing to myeloper-oxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity towards cultured endothelial cells
5. Antioxidant protection in collagen-vascular diseases
6. Neutrophil priming and apoptosis in ANCA-associated vasculitis
7. Methylprednisolone normalises superoxide anion production by the polymorphs from patients with ANCA-positive vasculitis
8. Leucocyte adherence to venular endothelium during ischaemia-reperfusion
9. The microcirculation and inflammation modulation of leukocyte/endothelial cell adhesion
10. Role of oxygen radicals in the microcirculatory manifestations of ischaemia/reperfusion injury
11. Evidence for the role of oxygen radicals in acute nephrotoxic nephritis
12. Endogenous antioxidant defences in human blood plasma
13. Nomenclature of systemic vasculitides: The proposal of an International Consensus Conference
14. IL-1b production by human polymorpho-nuclear leukocytes stimualted by anti-neutrophil cytoplasmic autoantibodies: Relevance to systemic vasculitis
15. The activation of the neutrophil respiratory burst by anti-neutorphil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation
16. Enhanced chemiluminescent assay for antioxidant capacity in biological fluids
17. Total antioxidant capacity by enhanced chemiluminescence: Contribution of urate
18. Determination of ascorbic acid and dehydroascorbic acid in plasma and cerebrospinal fluid by liquid chromatography with electrochemical detection
19. Neutrophil superoxide anion-generating capacity, endothelial function and oxidative stress in chronic heart failure: Effects of short- and long-term vitamin C therapy
20. α-Tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease
21. The mechanism of action of the anti-inflammatory agents dexamethasone and auranofin in human polymorphonuclear leucocytes
22. Corticosteroid induced simultaneous changes in leucocyte phospholipids and superoxide anion production
23. Ascorbate is an outstanding antioxidant in human blood plasma
24. Oxidative stress and cardiac disease
25. Immunogenicity of homologous low-density lipoprotein after methylation, ethylation, acetylation or carbamylation: Generation of antibodies specific for derivatised lysine
26. Patients with systemic vasculitis have increased levels of autoantibodies against oxidised LDL
27. Vitamin supplementation reduces oxidative stress in conservatively managed patients with chronic renal failure