Degradation studies on biodegradable nanocomposite based on polycaprolactone/polycarbonate (80:20%) polyhedral oligomeric silsesquioxane

Journal of Biomedical Materials Research - Part A

Volumn 91, Issue 3, 2009, Pages 834-844

  Raghunath, Joanne ^a   Georgiou, George ^b   Armitage, David ^b   Nazhat, Showan N ^c   Sales, Kevin M ^a   Butler, Peter E ^d   Seifalian, Alexander M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Biodegradation; Cartilage; Nanocomposite; Scaffold; Soft tissue; Tissue engineering

Indexed keywords

BIOCOMPATIBLE POLYMER; BIODEGRADABLE NANOCOMPOSITES; CHONDROCYTES; COMPLEX TISSUES; CONTACT ANGLE ANALYSIS; CONTROLLED DEGRADATION; DEGRADATION STUDY; EXTRACELLULAR MATRICES; HYDROLYTIC ENZYME; HYDROPHOBIC POLYMERS; MECHANICAL ANALYSIS; MECHANICAL STRENGTH; NANOCAGES; PLASMA PROTEIN; POLYCARBONATE POLYURETHANES; POLYHEDRAL OLIGOMERIC SILSESQUIOXANES; SCAFFOLDS FOR TISSUE ENGINEERING; SOFT SEGMENTS; SOFT TISSUE; STRESS-STRAIN; STRUCTURAL STABILITIES; TISSUE ENGINEERING SCAFFOLD; X-RAY MICROANALYSIS;

BIOCHEMISTRY; BIODEGRADATION; BIOMECHANICS; CARTILAGE; CELL MEMBRANES; CONTACT ANGLE; DEGRADATION; ELECTRIC DISCHARGE MACHINING; ENGINEERING; GROWTH KINETICS; LIGAMENTS; MECHANICAL PROPERTIES; MICROBIOLOGY; NANOCOMPOSITES; ORGANIC POLYMERS; PHOTODEGRADATION; POLYMER BLENDS; POLYMERS; SCAFFOLDS; SCANNING ELECTRON MICROSCOPY; STABILITY; STRESSES; SURFACE TOPOGRAPHY;

TISSUE ENGINEERING;

HYDROLASE; NANOCOMPOSITE; PLASMA PROTEIN; POLYCAPROLACTONE; POLYCARBONATE; POLYURETHAN; TISSUE SCAFFOLD;

ARTICLE; BIODEGRADATION; CONTACT ANGLE; CONTROLLED STUDY; ELASTICITY; HYDROPHOBICITY; MOLECULAR MECHANICS; NANOFABRICATION; OXIDATION; PEROXIDATION; STRESS STRAIN RELATIONSHIP; TISSUE ENGINEERING;

BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; CARBON; CARTILAGE; CHONDROCYTES; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; NANOCOMPOSITES; ORGANOSILICON COMPOUNDS; OXYGEN; POLYCARBOXYLATE CEMENT; POLYESTERS; POLYMERS; POLYURETHANES; SPECTROPHOTOMETRY, INFRARED; SURFACE PROPERTIES; X-RAYS;

EID: 70350303345     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32335     Document Type: Article

References (41)

1. Santerre JP, Woodhouse K, Laroche G, Labow RS. Understanding the biodegradation of polyurethanes: From classical implants to tissue engineering materials. Biomaterials 2005;26:7457-7470. (Pubitemid 41133597)
2. Kannan RY, Salacinski HJ, Odlyha M, Butler PE, Seifalian AM. The degradative resistance of polyhedral oligomeric silsesquioxane nanocore integrated polyurethanes: An in vitro study. Biomaterials 2006;27:1971-1979. (Pubitemid 41759491)
3. Tang YW, Labow RS, Revenko I, Santerre JP. Influence of surface morphology and chemistry on the enzyme catalyzed biodegradation of polycarbonate-urethanes. J Biomater Sci Polym Ed 2002;13:463-483. (Pubitemid 34814823)
4. Sudaryanto, Nishino T, Asaoka S, Nakamae K. Incorporation of methyl groups into hard segments of segmented polyurethane: Microphase separation and adhesive properties. Int J Adhes Adhes 2001;21:71-75. (Pubitemid 32092922)
5. Chuang FS, Tsen WC, Shu YC. The effect of different siloxane chain-extenders on the thermal degradation and stability of segmented polyurethanes. Polym Degrad Stab 2004;84:69-77.
6. Ebert M, Ward B, Anderson J, McVenes R, Stokes K. In vivo biostability of polyether polyurethanes with polyethylene oxide surface-modifying end groups; resistance to biologic oxidation and stress cracking. J Biomed Mater Res A 2005;75:175-184.
7. Stokes K, Coury A, Urbanski P. Autooxidative degradation of implanted polyether polyurethane devices. J Biomater Appl 1987;1:411-448.
8. Stokes K, McVenes R, Anderson JM. Polyurethane elastomer biostability. J Biomater Appl 1995;9:321-354.
9. Santerre JP, Labow RS, Duguay DG, Erfle D, Adams GA. Biodegradation evaluation of polyether and polyester-urethanes with oxidative and hydrolytic enzymes. J Biomed Mater Res 1994;28:1187-1199. (Pubitemid 24303144)
10. Tanzi MC, Fare S, Petrini P. In vitro stability of polyether and polycarbonate urethanes. J Biomater Appl 2000;14:325-348.
11. Edwards A, Carson RJ, Szycher M, Bowald S. In vitro and in vivo biodurability of a compliant microporous vascular graft. J Biomater Appl 1998;13:23-45.
12. Woo GL, Mittelman MW, Santerre JP. Synthesis and characterization of a novel biodegradable antimicrobial polymer. Biomaterials 2000;21:1235-1246. (Pubitemid 30195721)
13. Christenson EM, Dadsetan M, Wiggins M, Anderson JM, Hiltner A. Poly(carbonate urethane) and poly(ether urethane) biodegradation: In vivo studies. J Biomed Mater Res A 2004; 69:407-416.
14. Capone CD. Biostability of a non-ether polyurethane. J Biomater Appl 1992;7:108-129.
15. Rhodes NP, Bellon JM, Bujan MJ, Soldani G, Hunt JA. Inflammatory response to a novel series of siloxane-crosslinked polyurethane elastomers having controlled biodegradation. J Mater Sci Mater Med 2005;16:1207-1211. (Pubitemid 41803747)
16. Christenson EM, Dadsetan M, Hiltner A. Biostability and macrophage-mediated foreign body reaction of silicone-modified polyurethanes. J Biomed Mater Res A 2005;74:141-155. (Pubitemid 40995528)
17. Simmons A, Hyvarinen J, Odell RA, Martin DJ, Gunatillake PA, Noble KR, Poole-Warren LA. Long-term in vivo biostability of poly(dimethylsiloxane)/ poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomers. Biomaterials 2004;25:4887-4900. (Pubitemid 38520819)
18. Martin DJ, Warren LA, Gunatillake PA, McCarthy SJ, Meijs GF, Schindhelm K. Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: Biostability. Biomaterials 2000;21:1021-1029. (Pubitemid 30145693)
19. Zhang Y, Sun H, Chen C Superhard cubic BC2N compared to diamond. Phys Rev Lett 2004;93:195504.
20. Gao H, Ji B, Jager IL, Arzt E, Fratzl P. Materials become insensitive to flaws at nanoscale: Lessons from nature. Proc Natl Acad Sci USA 2003;100:5597-5600. (Pubitemid 36576853)
21. Fong H, Dickens SH, Flaim GM. Evaluation of dental restorative composites containing polyhedral oligomeric silsesquioxane methacrylate. Dent Mater 2005;21:520-529.
22. Kannan RY, Salacinski HJ, De GJ, Clatworthy I, Bozec L, Horton M, Butler PE, Seifalian AM. The antithrombogenic potential of a polyhedral oligomeric silsesquioxane (POSS) nanocomposite. Biomacromolecules 2006;7:215-223. (Pubitemid 43154497)
23. Kannan RY, Salacinski HJ, Butler PE, Seifalian AM. Polyhedral oligomeric silsesquioxane nanocomposites: The next generation material for biomedical applications. Acc Chem Res 2005;38:879-884.
24. Hoshino A, Isono Y. Degradation of aliphatic polyester films by commercially available lipases with special reference to rapid and complete degradation of poly(L-lactide) film by lipase PL derived from Alcaligenes sp. Biodegradation 2002;13:141-147. (Pubitemid 35257062)
25. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543. (Pubitemid 30706202)
26. Zeng J, Chen X, Liang Q, Xu X, Jing X. Enzymatic degradation of poly(L-lactide) and poly(epsilon-caprolactone) electrospun fibers. Macromol Biosci 2004;4:1118-1125. (Pubitemid 40095215)
27. Ang KC, Leong KF, Chua CK, Chandrasekaran M. Compressive properties and degradability of poly(epsilon-caprolatone)/hydroxyapatite composites under accelerated hydrolytic degradation. J Biomed Mater Res A 2007;80:655-660. (Pubitemid 46239077)
28. Sarasam AR, Krishnaswamy RK, Madihally SV. Blending chitosan with polycaprolactone: Effects on physicochemical and antibacterial properties. Biomacromolecules 2006;7:1131-1138.
29. Seifalian AM, Handcock S, Salacinski HJ. Polymer for use in conduits and medical devices. WOPatent WO2,005,070,998, 2005.
30. Zhao Q, Casas-Bejar J, Urbanski P, Stokes K. Glass wool-H2O2/CoCl2 test system for in vitro evaluation of biodegradative stress cracking in polyurethane elastomers. J Biomed Mater Res 1995;29:467-475.
31. Zhao QH, McNally AK, Rubin KR, Renier M, Wu Y, Rose-Caprara V, Anderson JM, Hiltner A, Urbanski P, Stokes K. Human plasma alpha 2-macroglobulin promotes in vitro oxidative stress cracking of Pellethane 2363-80A: In vivo and in vitro correlations. J Biomed Mater Res 1993;27:379-388.
32. Meijs GF, McCarthy SJ, Rizzardo E, Chen YC, Chatelier RC, Brandwood A, Schindhelm K. Degradation of medical-grade polyurethane elastomers: The effect of hydrogen peroxide in vitro.. J Biomed Mater Res 1993;27:345-356. (Pubitemid 23068739)
33. Takahara A, Hergenrother RW, Coury AJ, Cooper SL. Effect of soft segment chemistry on the biostability of segmented polyurethanes. II. In vitro hydrolytic degradation and lipid sorption. J Biomed Mater Res 1992;26:801-818.
34. Salacinski HJ, Tai NR, Carson RJ, Edwards A, Hamilton G, Seifalian AM. In vitro stability of a novel compliant poly(carbonate-urea)urethane to oxidative and hydrolytic stress. J Biomed Mater Res 2002;59:207-218.
35. Elzein T, Nasser-Eddine M, Delaite C, Bistac S, Dumas P. FTIR study of polycaprolactone chain organization at interfaces. J Colloid Interface Sci 2004;273:381-387. (Pubitemid 38481936)
36. Raghunath J, Salacinski HJ, Sales KM, Butler PE, Seifalian AM. Advancing cartilage tissue engineering: The application of stem cell technology. Curr Opin Biotechnol 2005;16:503-509. (Pubitemid 41393829)
37. Perez OM, Garcia-Giralt N, Pradas MM, Ruiz PB, Gomez Ribelles JL, Palou EC, Garcia JC. Response of human chondrocytes to a non-uniform distribution of hydrophilic domains on poly(ethyl acrylate-co-hydroxyethyl methacrylate) copolymers. Biomaterials 2006;27:1003-1012. (Pubitemid 41566692)
38. Tang YW, Labow RS, Santerre JP. Isolation of methylene dianiline and aqueous-soluble biodegradation products from polycarbonate-polyurethanes. Biomaterials 2003;24:2805-2819.
39. Chan SC, Birdsell DC, Gradeen CY. Urinary excretion of free toluenediamines in a patient with polyurethane-covered breast implants. Clin Chem 1991;37:2143-2145. (Pubitemid 21925919)
40. Hester TR Jr, Ford NF,Gale PJ, Hammett JL, Raymond R, Turnbull D, Frankos VH, Cohen MB. Measurement of 2,4-toluenediamine in urine and serum samples from women with Meme or Replicon breast implants. Plast Reconstr Surg 1997;100:1291-1298. (Pubitemid 27426034)
41. Kulig K. Lifetime risk from polyurethane covered breast implants. Environ Health Perspect 1998;106:A526-A527.