Evaluation of the uterotonic activity of the aqueous leaf extract of Ficus exasperata vahl (Moraceae)

Research Journal of Medicinal Plant

Volumn 3, Issue 2, 2009, Pages 34-40

  Bafor, Enitome E ^a   Omogbai, Eric K ^a   Ozolua, Raymond I ^a  

^a UNIVERSITY OF BENIN   (Nigeria)

Author keywords

Acetylcholine; Aqueous extract; Ficus exasperata; Utems; Uterine contraction

Indexed keywords

ACETYLCHOLINE; ALKALOID DERIVATIVE; ANTHRACENE DERIVATIVE; CARDIAC GLYCOSIDE; FICUS EXASPERATA EXTRACT; FLAVANOID; PLANT EXTRACT; SALBUTAMOL; SAPONIN; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; UTEROTONIC AGENT; WATER;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; FEMALE; FICUS; FICUS EXASPERATA; IN VITRO STUDY; ISOLATED ORGAN; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; UTERUS CONTRACTILITY; UTERUS CONTRACTION;

FICUS EXASPERATA; MORACEAE;

EID: 70350273382     PISSN: 18193455     EISSN: None     Source Type: Journal    
DOI: 10.3923/rjmp.2009.34.40     Document Type: Article

References (17)

1. +-channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats. Br. J. Pharmacol., 147: 815-824.
2. Ake, A.L., 1990. Utilisation de diverses especes de ficus (Moraceae) dans la pharmacopee traditionnelle africaine de côte d'Ivoire. Mitt. Inst. Allg. Bot., 23: 1039-1046.
3. Baerts, M. and J. Lehmann, 1991. Plantes meedicinales veterinaries de la region des cretes zaire-nil au burndi musee royal de l'Airique centrale, Tervuren. Ann. Sci. Eco., 13: 211-233.
4. Calixto, B.J., N. Mauro and G.A. Rae, 1986. Pharmacological actions of tannic acid. I. Effects on isolated smooth and cardiac muscles and on blood pressure. Planta Med., 52: 32-35.
5. Edwards, C.R., R. Benediktsson, R.S. Lindsay and J. Seckl, 1996. 11 beta-Hydroxysteroid dehydrogenases: Key enzymes in determining tissue specific glucocorticoid effects. Ster, 4: 263-269.
6. Eferekeya, A. and Z. Nworgu, 1985. Inhibitory effects of gallopamil and hydralazine on early and late pregnant uteri. Nig. J. Pharm. Sci., 1: 67-71.
7. Evans, W.C., 2002. Pharmacopoieal and Related Drugs of Biological Origin. In: Pharmacognosy, Evans, W.C. and D. Evans (Eds.). WB Saunders Co. Ltd., London, ISBN: 0 7020 2617 4, pp: 374.
8. Hostettmann, K., A. Marston, K. Ndjoko and J.L. Wolfender, 2000. The potential of African plants as a source of drugs. Cur. Organic Chem., 4: 973-1010.
9. Ijeh, I.I. and A.I. Ukweni, 2007. Acute effect of administration of ethanol extracts of Ficus exasperata vahl on kidney function in albino rats. J. Med. Plant Res., 1: 027-029.
10. Kurowicka, B., A. Franczak, A. Oponowicz and G. Kotwicka, 2005. In vitro contractile activity of porcine myometrium during luteolysis and early pregnancy: Effect of oxytocin and progesterone. Reprod. Biol., 2: 151-169.
11. Mackler, A.M., C.A. Ducsay, J.D. Vudhuis and S.M. Yellon, 1999. Maturation of spontaneous and agonist-induced uterine contractions in the peripartum mouse uterus. Biol. Reprod., 61: 873-878.
12. Norris, P.R., 1961. The action of cardiac glycosides on the human uterus. J. Obstet. Gynaec. Brit. Cwlth, 68:916-929.
13. Pennefather, J.N., T.A. Gillman and F. Mitchelson, 1994. Muscarinic receptors in rat uterus. Eur. J. Pharmacol, 262: 297-300.
14. Perusquia, M. and E. Navarette, 2005. Evidence that 17α-estradiol is biologically active in the uterine tissue: Antiuterotonic and antiuterotrophic action. Reprod. Biol. Endocrinol., 3: 30-30.
15. Sugimoto, T., 1913. Pharmakologische Untersuchungen am uberlebenden meerschweinchenuterus. Naunyn-Schmiedeberg's Arch. Exp. Path. Pharmak., 74: 27-40.
16. Umerie, S.C., A.S. Ogbuagu and J.O. Ogbuagu, 2004. Stabilization of palm oils by using 21.ficus exasperata leaves in local processing methods. Bioresour. Technol., 94: 307-310.
17. Vane, J.R. and K.I. Williams, 1973. The contribution of prostaglandin production to contractions of the isolated uterus of the rat. Br. J. Pharmacol, 48: 629-639.