Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa

Inflammation Research

Volumn 57, Issue 1, 2008, Pages 39-43

  Zamora, Z ^a   Gonzalez R ^a   Guanche, D ^a   Merino, N ^b   Menendez S ^a   Hernandez F ^b   Alonso, Y ^a   Schulz, S ^c  

^a Ozone Research Center Havana   (Cuba)

^b Center of Pharmaceutical Chemistry Cuba   (Cuba)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antioxidants; Catalase; Gastric lesions; Indomethacin; Oxidative stress; Ozonized sunflower oil; Rats; Superoxide dismutase

Indexed keywords

CATALASE; CIMETIDINE; INDOMETACIN; REACTIVE OXYGEN METABOLITE; SUNFLOWER OIL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; OZONATION; RAT; STOMACH HEMORRHAGE; STOMACH MUCOSA LESION; STOMACH ULCER;

ANIMALS; GASTRIC MUCOSA; INDOMETHACIN; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; OZONE; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 38649129776     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-7034-1     Document Type: Article

References (25)

1. Mc Carthy DM. Mechanism of mucosal injury and healing: the role of non-steroidal anti-inflammatory drugs. Scand J Gastroenterol 1995; 30: 24-9.
2. Mahmud T, Scott DL, Bjarnason. A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity. Ann Rheum Dis 1996; 55: 211-3.
3. Sechi LA, Lezcano I, Nuñez N, Espino M. Antibacterial activity of ozonized sunflower oil (OLEOZON). J Appl Microbiol 2001; 90: 279.
4. Remigio A, González Y, Zamora Z, Moleiro J. Genotoxic evaluation of OLEOZON by micronucleus assays in bone marrow and peripheral blood in mice. Revista CENIC, Ciencias Biológicas 1998; 28: 200-2.
5. Zamora ZR, Torres D, Bouza M, Hernández D, Hernández F. Oral OLEOZON®, is an effective treatment in experimental giardiasis. Revista CENIC Ciencias Biológicas 2006; 37: 45-8.
6. Bailey, P. S. Ozonation in Organic Chemistry: olefinic compounds, Vol. I & II, Academic Press, New York, USA, 1978.
7. Ledea O, Correa T, Moleiro J, Jardines D, Escobar M, Rosado A, Hernandez, C. Volatile components of ozonized sunflower oil "OLEOZON ®".Ozone Sci Eng 2001; 23: 121-6.
8. Diaz M, Gavin J, Hernandez F, Ledea O, Moleiro J. Study of H NMR methyl linoleate ozonation. Ozone Sci Eng 2003; 5: 121-6.
9. Allen JC, Halimton RJ. Rancidity and foods, Blackie Academic and Professional, London, UK, 2000.
10. Jardines D, Correa T, Ledea O, Zamora Z, Rosado A. and Moleiro J. Gas Chromatography-Mass Spectrometry profile of urinary organic acids of wistar rats orally treated with ozonized unsaturated triglycerides and ozonized sunflower oil. J of Chromatography B 20033; 783: 517-25.
11. Alarcon CL, Motilva V, Martin M J, Nieto A, Barranco MD, Herrerías JM. Protective effect of melatonin on indomethacin-induced gastric injury in rats. J Pineal Res 1999; 26: 101-7.
12. Martin MJ, Motilva V, Alarcon de la Lastra C. Guercetin and naringenin, effects on ulcer formation and gastric secretion in rats. Phytother Res 1993; 7: 150-3.
13. Tabuchi Y, Kurebayashi Y. Antisecretory and antiulcer effects of ebselen, a seleno-organic compound, in rats. Jpn J Pharmacol 1993; 61: 255-7.
14. Yoshikawa T, Naito Y, Tanigawa T, Kondo M. Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance. Arzneim Forsch/Drug Res 1993; 43: 363-6.
15. Kochkov VN. And Leitinger N. Anti-inflammatory properties of lipid oxidation products. J Mol Med 2003; 81: 613-26.
16. Leitinger N. Oxidized phospholipids as modulators of inflammation in atherosclerosis. Curr Opin Lipidol 2003; 14: 421-30.
17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxide for animal tissues by thiobarbituric acid reaction. Ann Biochem 1979; 95: 351-8.
18. Minami M, Yoshikawa H. A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 1979; 92: 337-72.
19. Rice Evans C, Diplock AT. Laboratory Techniques in Biochemistry and Molecular Biology. In: Burtin RH, Knippenberg PH, eds Techniques in Free Radical Research. The Netherlands: Elsevier 1991, p. 199-201.
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 165-75.
21. Guzel C, Ulak G, Sermet A, Cicek R, Ulak M. Effect of fish oil on indomethacin-induced gastric lesions in rats. Arzneim-Forsch 1995; 45: 1172-3.
22. Alarcon CL, Barranco MD, Martin MJ, Herrera J, Motilva V. Extravirgin olive oil-enriched diets reduces indomethacin-induced gastric oxidative damage in rats. Digest Dis Sci 2002; 47: 2783-90.
23. Tanaka J, Yuda Y. Lipid peroxidation in gastric mucosal lesions induced by indomethacin in rat. Biol Pharm Bull 1996; 19: 716-20.
24. Van der Vliet A, Bast A. Role of reactive oxygen species in intestinal diseases. Free Rad Biol Med 1992; 12: 499-513.
25. Grisham MB, Granger DN. Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988; 33 (suppl 3): 65-155.