Alport Syndrome mutations in type IV tropocollagen alter molecular structure and nanomechanical properties

Journal of Structural Biology

Volumn 168, Issue 3, 2009, Pages 503-510

  Srinivasan, Maya ^a,b   Uzel, Sebastien G M ^a   Gautieri, Alfonso ^a,c   Keten, Sinan ^a   Buehler, Markus J ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b Princeton University   (United States)

^c POLITECNICO DI MILANO   (Italy)

Author keywords

Alport Syndrome; Breakdown; Computational biology; Defects; Elasticity; Failure; Flaws; Genetic disease; Materiomics; Mechanical property; Nanomechanics; Protein material

Indexed keywords

AMINO ACID; GLYCINE; TROPOCOLLAGEN; TROPOCOLLAGEN TYPE 4; UNCLASSIFIED DRUG;

ALPORT SYNDROME; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD FLOW; CHEMICAL STRUCTURE; DISEASE SEVERITY; GENE MUTATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RIGIDITY; SIMULATION; STRESS STRAIN RELATIONSHIP;

AMINO ACID SEQUENCE; ANIMALS; BIOMECHANICS; COMPUTATIONAL BIOLOGY; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NEPHRITIS, HEREDITARY; TROPOCOLLAGEN;

EID: 70350233283     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2009.08.015     Document Type: Article

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