A drug-in-adhesive transdermal patch for S-amlodipine free base: In vitro and in vivo characterization

International Journal of Pharmaceutics

Volumn 382, Issue 1-2, 2009, Pages 165-171

  Sun, Yinghua ^a   Fang, Liang ^a   Zhu, Meng ^a   Li, Wei ^a   Meng, Ping ^a   Li, Li ^b   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY   (China)

Author keywords

Drug in adhesive transdermal patch; Pharmacokinetics; Rat; S amlodipine

Indexed keywords

AMLODIPINE BESYLATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PENETRATION; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSDERMAL PATCH; TRANSPORT KINETICS;

ADHESIVES; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; AMLODIPINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DOSAGE FORMS; DRUG COMPOUNDING; INJECTIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; PERMEABILITY; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SOLUBILITY;

EID: 70350198027     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.08.031     Document Type: Article

References (14)

1. Barratt M.D. Quantitative structure-activity relationships for skin permeability. Toxic. In Vitro 9 (1995) 27-37
2. dos Anjos J.L., de Sousa Neto D., and Alonso A. Effects of ethanol/l-menthol on the dynamics and partitioning of spin-labeled lipids in the stratum corneum. Eur. J. Pharm. Biopharm. 67 (2007) 406-412
3. Francoeur, M.L., Potts, R.O., 1988. Transdermal flux enhancing compositions. EP Patent Application 0271983, 22 June.
4. Fujimura A., Shiga T., Ohashi K., and Ebihara A. Chronopharmacology of amlodipine in rats. Life Sci. 53 (1993) 595-602
5. Goldmann S., Stoltefuss J., and Born L. Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction. J. Med. Chem. 35 (1992) 3341-3344
6. Jiang Y., Fang L., Niu X., Rui M., and He Z. The effect of ion pairing on the skin permeation of amlodipine. Pharmazie 63 (2008) 356-360
7. Lave T., Dupin S., Schmitt C., Chou R.C., Jaeck D., and Coassolo P. Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs. J. Pharm. Sci. 86 (1997) 584-590
8. McDaid D.M., and Deasy P.B. Formulation development of a transdermal drug delivery system for amlodipine base. Int. J. Pharm. 133 (1996) 71-83
9. Panchagnula R., Desu H., Jain A., and Khandavilli S. Feasibility studies of dermal delivery of paclitaxel with binary combinations of ethanol and isopropyl myristate: role of solubility, partitioning and lipid bilayer perturbation. Farmaco 60 (2005) 894-899
10. Park J.Y., Kim K.A., Park P.W., Lee O.J., Ryu J.H., Lee G.H., Ha M.C., Kim J.S., Kang S.W., and Lee K.R. Pharmacokinetic and pharmacodynamic characteristics of a new S-amlodipine formulation in healthy Korean male subjects: a randomized, open-label, two-period, comparative, crossover study. Clin. Ther. 28 (2006) 1837-1847
11. Stopher D.A., Beresford A.P., Macrae P.V., and Humphrey M.J. The metabolism and pharmacokinetics of amlodipine in humans and animals. J. Cardiovasc. Pharmacol. 12 (1988) S55-S59
12. Tenjarla S.N., Allen R., and Borazani A. Evaluation of verapamil hydrochloride permeation through human cadaver skin. Drug Dev. Ind. Pharm. 20 (1994) 49-63
13. Valiverti S., Hammell D.C., Paudel I.S., Hamad M.O., Crooks P.A., and Stinchcomb A.L. In vivo evaluation of 3-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs. J. Control. Release 102 (2005) 509-520
14. Zhang X.P., Loke K.E., Mital S., Chahwala S., and Hintze T.H. Paradoxical release of nitric oxide by an L-type calcium channel antagonist, the R+ enantiomer of amlodipine. J. Cardiovasc. Pharmacol. 39 (2002) 208-214