An improved ion chromatographic method for fast and sensitive determination of N-methylpyrrolidine in cefepime hydrochloride

Journal of Chromatographic Science

Volumn 47, Issue 7, 2009, Pages 549-552

  Subramanian, Narayanan Harihara ^a   Thyagarajan, Shanmugam ^a   Manigandan, Parthasarathy ^a   Ganesh Jeevan, R ^b   Radhakrishnan, Ganga ^b  

^a Application Lab   (India)

^b CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70350191634     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/47.7.549     Document Type: Article

References (6)

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2. N. Baririan, H. Chanteux, E. Viaene, H. Servais, and P.M. Tulkens. Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units. J. Antimicrob. Chemother. 51: 651-658 (2003).
3. S.M. Rabouan-Guyon, A.F. Guet, P.Y. Courtois, and D.M.C. Barthes. Stability study of cefepime in different infusion solutions. Int. J. Pharm. 154: 185-190 (1997).
4. S.T. Forgue, P. Kari, and R. Barbhaiya. N-oxidation of N-methylpyrrolidine released in vivo from cefepime. Drug Metab. Dispos. 15: 808-815 (1987).
5. G. Chen, G. Liu, F. Qin, and Y. Wang. A simple and sensitive GC method for determination of N-methylpyrrolidine in cefepime and its preparation. J. Pharm. Biomed. Anal. 33: 797-801 (2003).
6. H. Liu and V.B. Sunderland. Determination of N-methylpyrrolidine in cefepime for injection by capillary electrophoresis with indirect UV detection. Chromatographia 54: 653-657 (2003).