Stability and antibacterial activity of cefepime during continuous infusion

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 6, 2003, Pages 1991-1994

  Sprauten, Pål F ^a,b   Beringer, Paul M ^b,d   Louie, Stan G ^b   Synold, Timothy W ^c   Gill, Mark A ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; COLONY FORMING UNIT; CONTINUOUS INFUSION; DRUG DEGRADATION; DRUG INFUSION; DRUG STABILITY; DRUG STORAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFUSION PUMP; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TEMPERATURE;

ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; DRUG STABILITY; DRUG STORAGE; INFUSION PUMPS; INFUSIONS, INTRAVENOUS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA;

EID: 0038778653     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.6.1991-1994.2003     Document Type: Article

References (16)

1. Arguedas, A. G., H. R. Stutman, M. Zaleska, C. A. Knupp, M. I. Marks, and E. Nussbaum. 1992. Cefepime pharmacokinetics and clinical response in patients with cystic fibrosis. Am. J. Dis. Child. 146:797-802.
2. Craig, W. A. 2002. Pharmacodynamics of antimicrobials: general concepts and applications, p. 1-22. In C. H. Nightingale (ed.), Antimicrobial pharmacodynamics in theory and clinical practice. Marcel Dekker, Inc., New York, N.Y.
3. Elkhaili, H., L. Linger, H. Monteil, and F. Jehl. 1997. High-performance liquid chromatographic assay for cefepime in serum. J. Chromatogr. B 690:181-188.
4. Fubara, J. O., and R. E. Notari. 1998. Influence of pH, temperature and buffers on cefepime degradation kinetics and stability predictions in aqueous solutions. J. Pharm. Sci. 87:1572-1576.
5. Fubara, J. O., and R. E. Notari. 1997. A kinetic oxymoron: concentration-dependent first-order rate constants for hydrolysis of ceftazidime. J. Pharm. Sci. 87:53-57.
6. Grant, E. M., J. Kuti, D. P. Nicolau, C. H. Nightingale, and R. Quintiliani. 2002. Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospital. Pharmacotherapy 22:471-483.
7. Hamelin, B. A., N. Moore, C. A. Knupp, M. Ruel, F. Vallee, and M. LeBel. 1993. Cefepime pharmacokinetics in cystic fibrosis. Pharmacotherapy 13:465-470.
8. Huls, C. E., R. A. Prince, D. K. Seilheimer, and J. A. Bosso. 1993. Pharmacokinetics of cefepime in cystic fibrosis patients. Antimicrob. Agents Chemother. 37:1414-1416.
9. Ip, M., C. Au, S. W. Cheung, C. Y. Chan, and A. F. Cheng. 1998. A rapid high-performance liquid chromatographic assay for cefepime, cefpirome and meropenem. J. Antimicrob. Chemother. 42:121-123.
10. MacGowan, A. P., and K. Bowker. 1998. Continuous infusion of beta-lactam antibiotics. Clin. Pharmacokinet. 35:391-402.
11. Sugioka, T., T. Asano, Y. Chikaraishi, E. Suzuki, A. Sano, T. Kuriki, M. Shirotsuka, and K. Saito. 1990. Stability and degradation pattern of cefpirome (HR 810) in aqueous solution. Chem. Pharm. Bull. 38:1998-2002.
12. Tessier, P. R., D. P. Nicolau, C. Onyeji, and C. H. Nightingale. 1999. Pharmacodynamics of intermittent- and continuous-infusion cefepime alone and in combination with once-daily tobramycin against Pseudomonas aeruginosa in an in vitro infection model. Chemotherapy 45:284-295.
13. Viaene, E., H. Chanteux, H. Servais, M. P. Mingeot-Leclercq, and P. M. Tulkens. 2002. Comparative stability studies of antipseudomonal β-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units). Antimicrob. Agents Chemother. 46:2327-2332.
14. Vinks, A. A., D. J. Touw, H. G. Heijerman, M. Danhof, G. P. de Leede, and W. Bakker. 1994 Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home. Ther. Drug Monit. 16:341-348.
15. Vondracek, T. G. 1995. Beta-lactam antibiotics: is continuous infusion the preferred method of administration? Ann. Pharmacother. 29:415-423.
16. Williamsen, J., D. Volles, P. Lynch, P. Rogers, and D. Haverstick. 1999. Stability of cefepime in peritoneal dialysis solution. Ann. Pharmacother. 33:906-909.