A comparison of adherence assessment methods utilized in the United States: Perspectives of researchers, HIV-infected children, and their caregivers

AIDS Patient Care and STDs

Volumn 23, Issue 8, 2009, Pages 593-601

  Martin, Staci ^a,b,f   Elliott Desorbo, Deborah K ^a,c   Calabrese, Sarah ^a   Wolters, Pamela L ^a,b   Roby, Gregg ^a,d   Brennan, Tara ^a,e   Wood, Lauren V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Medical Illness Counseling Center   (United States)

^c UNITED STATES AIR FORCE ACADEMY   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CAREGIVER; CD4 LYMPHOCYTE COUNT; CHILD; CLINICAL ARTICLE; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERVIEW; MALE; PATIENT COMPLIANCE; PERCEPTIONS OF ADHERENCE STUDY PARTICIPATION QUESTIONNAIRE; QUESTIONNAIRE; SOCIAL DESIRABILITY; UNITED STATES;

ADOLESCENT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CAREGIVERS; CHILD; DRUG MONITORING; FAMILY; HEALTH PERSONNEL; HIV INFECTIONS; HUMANS; INTERVIEWS AS TOPIC; PARENTS; PATIENT COMPLIANCE; QUESTIONNAIRES; RESEARCH; UNITED STATES;

EID: 70350167819     PISSN: 10872914     EISSN: None     Source Type: Journal    
DOI: 10.1089/apc.2009.0021     Document Type: Article

References (47)

1. Berk DR, Falkovitz-Halpern MS, Hill DW, et al. Temporal trends in early clinical manifestations of perinatal HIV infection in a population-based cohort. JAMA 2005;293:2221-2231.
2. Gortmaker SL, Hughes, M, Cervia, J, et al. Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. N Engl J Med 2001;345:1522-1528.
3. Harrigan PR, Hogg RS, Dong WW, et al. Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. J Infect Dis 2005;191:339-347.
4. Sethi AK, Celentano DD, Gange SJ, Moore RD, Gallant JE. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clin Infect Dis 2003;37:1112-1118.
5. Barclay TR, Hinkin CH, Castellon SA, et al. Age-associated predictors of medication adherence in HIV-positive adults: Health beliefs, self-efficacy, and neurocognitive status. Health Psychol 2007;26:40-49.
6. Flandre P, Peytavin G, Meiffredy V, et al. Adherence to antiretroviral therapy and outcomes in HIV-infected patients enrolled in an induction=maintenance randomized trial. Antivir Ther 2002;7:113-121.
7. Goldman JD, Cantrell RA, Mulenga LB, et al. Simple adherence assessments to predict virologic failure among HIVinfected adults with discordant immunologic and clinical responses to antiretroviral therapy. AIDS Research Hum Retrovir 2008;24:1031-1035.
8. Hugen PW, Langebeek N, Burger DM, et al. Assessment of adherence to HIV protease inhibitors: Comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring. J Acquir Immune Defic Syndr 2002;30: 324-334.
9. Farley JJ, Montepiedra G, Storm D, et al. Assessment of adherence to antiretroviral therapy in perinatally HIV-infected children and youth using self-report measures and pill count. J Dev Behav Pediatrics 2008;29:377-384.
10. Marhefka SL, Koenig LJ, Allison S, et al. Family experiences with pediatric antiretroviral therapy: Responsibilities, barriers, and strategies for remembering medications. AIDS Patient Care STDs 2008;22:637-647.
11. Mellins CA, Brackis-Cott E, Dolezal C, Abrams EJ. The role of psychosocial and family factors in adherence to antiretroviral treatment in human immunodeficiency virusinfected children. Pediatr Infect Dis J 2004;23:1035-1041.
12. Williams PL, Storm D, Montepiedra G, et al. Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics 2006;118:e1745-e1757.
13. Levine AJ, Hinkin CH, Marion S, et al. Adherence to antiretroviral medications in HIV: Differences in data collected via self-report and electronic monitoring. Health Psychol 2006;25:329-335.
14. Llabre MM, Weaver KE, Duran RE, Antoni MH, McPherson- Baker S, Schneiderman N. A measurement model of medication adherence to highly active antiretroviral therapy and its relation to viral load in HIV-positive adults. AIDS Patient Care STDs 2006;20:701-711.
15. Farley JJ, Hines S, Musk A, Ferrus S, Tepper V. Assessment of adherence to antiviral therapy in HIV-infected children using the medication event monitoring system, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. J Acquir Immune Defic Syndr 2003;33: 211-218.
16. Paes AH, Bakker A, Soe-Agnie CJ. Measurement of patient compliance. Pharm World Sci 1998;20:73-77.
17. Farmer KC. Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 1999;21:1074-1090.
18. Kalichman SC, Amaral CM, Cherry C, et al. Monitoring medication adherence by unannounced pill counts conducted by telephone: Reliability and criterion-related validity. HIV Clin Trials 2008;9:298-308.
19. Craig HM. Accuracy of indirect measures of medication compliance in hypertension. Res Nurs Health 1985;8:61-66.
20. Deschamps AE, De Geest S, Vandamme AM, Bobbaers H, Peetermans WE, Van Wijngaerden E. Diagnostic value of different adherence measures using electronic monitoring and virologic failure as reference standards. AIDS Patient Care STDs 2008;22:735-743.
21. Munoz-Moreno JA, Fumaz CR, Ferrer MJ, et al. Assessing self-reported adherence to HIV therapy by questionnaire: The SERAD (Self-Reported Adherence) Study. AIDS Res Hum Retroviruses 2007;23:1166-1175.
22. Murri R, Ammassari A, Gallicano K, et al. Patient-reported nonadherence to HAART is related to protease inhibitor levels. J Acquir Immune Defic Syndr 2000;24:123-128.
23. Simoni JM, Kurth AE, Pearson CR, Pantalone DW, Merrill JO, Frick PA. Self-report measures of antiretroviral yherapy adherence: A review with recommendations for HIV research and clinical management. AIDS Behav 2006;10:227-245.
24. Duong M, Piroth L, Peytavin G, et al. Value of patient selfreport and plasma human immunodeficiency virus protease inhibitor level as markers of adherence to antiretroviral therapy: Relationship to virologic response. Clin Infect Dis 2001;33:386-392.
25. Kimmerling M, Wagner GJ, Ghosh-Dastidar B. Factors associated with accurate self-reported adherence to HIV antiretrovirals. Int J STD AIDS 2003;14:281-284.
26. Wagner GJ. Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries. AIDS Patient Care STDs 2002;16:599-608.
27. Simoni JM, Frick PA, Lockhart D, Liebovitz D. Mediators of social support and antiretroviral adherence among an indigent population in New York City. AIDS Patient Care STDs 2002;16:431-439.
28. Wagner GJ, Miller LG. Is the influence of social desirability on patients' self-reported adherence overrated? J Acquir Immune Defic Syndr 2004;35:203-204.
29. Dolezal C, Mellins C, Brackis-Cott E, Abrams EJ. The reliability of reports of medical adherence from children with HIV and their adult caregivers. J Pediatr Psychol 2003;28: 355-361.
30. Arnsten JH, Demas PA, Farzadegan H, et al. Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: Comparison of self-report and electronic monitoring. Clin Infect Dis 2001;33:1417-1423.
31. Giacomet V, Albano F, Starace F, et al. Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection: A multicentre, national study. Acta Paediatr 2003;92:1398-1402.
32. Deschamps AE, Graeve VD, van Wijngaerden E, et al. Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using Medication Event Monitoring System. AIDS Patient Care STDs 2004; 18:644-657.
33. Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 2000;133:21-30.
34. Avants SK, Margolin A, Warburton LA, Hawkins KA, Shi J. Predictors of nonadherence to HIV-related medication regimens during methadone stabilization. Am J Addict 2001;10: 69-78.
35. Eldred LJ, Wu AW, Chaisson RE, Moore RD. Adherence to antiretroviral and pneumocystis prophylaxis in HIV disease. J Acquir Immune Defic Syndr Hum Retrovirol 1998;18: 117-125.
36. Heckman BD, Catz SL, Heckman TG, Miller JG, Kalichman SC. Adherence to antiretroviral therapy in rural persons living with HIV disease in the United States. AIDS Care 2004;16:219-230.
37. Kleeberger CA, Buechner J, Palella F, et al. Changes in adherence to highly active antiretroviral therapy medications in the Multicenter AIDS Cohort Study. AIDS 2004;18:683-688.
38. Nieuwkerk P, Gisolf EH, Sprangers M, Danner SA. Adherence over 48 weeks in an antiretroviral clinical trial: Variable within patients, affected by toxicities and independently predictive of virological response. Antivir Ther 2001;6:97-103.
39. Weiss L, French T, Finkelstein R, Waters M, Mukherjee R, Agins B. HIV-related knowledge and adherence to HAART. AIDS Care 2003;15:673-679.
40. Wall TL, Sorensen JL, Batki SL, Delucchi KL, London JA, Chesney MA. Adherence to zidovudine (AZT) among HIVinfected methadone patients: A pilot study of supervised therapy and dispensing compared to usual care. Drug Alcohol Depend 1995;37:261-269.
41. Wendel CS, Mohler MJ, Kroesen K, Ampel NM, Gifford AL, Coons SJ. Barriers to use of electronic adherence monitoring in an HIV clinic. Ann Pharmacother 2001;35:1010-1015.
42. Wagner GJ. Does discontinuing the use of pill boxes to facilitate electronic monitoring impede adherence? Int J STD AIDS 2003;14:64-65.
43. Gross R, Bilker WB, Friedman HM, Strom BL. Effect of adherence to newly initiated antiretroviral therapy on plasma viral load. AIDS 2001;15:2109-2117.
44. Ickovics JR, Wilson TE, Royce RA, et al. Prenatal and postpartum zidovudine adherence among pregnant women with HIV: Results of a MEMS substudy from the Perinatal Guidelines Evaluation Project. J Acquir Immune Defic Syndr 2002;30:311-315.
45. Walsh JC, Mandalia S, Gazzard BG. Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome. AIDS 2002;16:269-277.
46. Wagner GJ, Rabkin JG. Measuring medication adherence: Are missed doses reported more accurately then perfect adherence? AIDS Care 2000;12:405-408.
47. Van Dyke RB, Lee S, Johnson GM, et al. Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infection. Pediatrics 2002;109:E61.