HLA class II polymorphism in children with coeliac disease in Tunisia: Is there any influence on clinical manifestation?

European Journal of Gastroenterology and Hepatology

Volumn 21, Issue 11, 2009, Pages 1286-1290

  Laadhar, Lilia ^a   Toumi, Amina ^a   Kallel Sellami, Maryam ^a,b   Zitouni, Mondher ^a   Bouraoui, Saadia ^b   Maherzi, Ahmed ^b   Makni, Sondès ^a,b   Ben Hariz, Mongi ^b  

^a LA RABTA HOSPITAL   (Tunisia)

^b Celiac Disease Research Unit   (Tunisia)

Author keywords

Atypical form; Children; Coeliac disease; DQ2; HLA

Indexed keywords

ENDOMYSIUM ANTIBODY; GENOMIC DNA; HLA DQ2 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN A ANTIBODY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ARTICLE; CELIAC DISEASE; CHILD; CHILDHOOD DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HISTOCOMPATIBILITY GENE; HLA DQA 1 GENE; HLA DQB 1 GENE; HLA DRB 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; JEJUNUM BIOPSY; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; TUNISIA;

CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; DIARRHEA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GROWTH DISORDERS; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HLA-D ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; POLYMORPHISM, GENETIC;

EID: 70350164005     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32832a7d74     Document Type: Article

References (28)

1. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000; 18:53-81.
2. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001; 120:636-651.
3. Catassi C, Ratsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F, et al. Celiac disease in year 2000: exploring the iceberg. Lancet 1994; 343:200-203.
4. Meloni G, Dore A, Fanciulli G, Tanda F, Bottazzo GF. Subclinical celiac disease in schoolchildren from northern Sardinia. Lancet 1999; 353:37.
5. Csizmadia CG, Mearin ML, von Blomberg BM, Brand R, Verloove-Vanhorick SP. An iceberg of childhood coeliac disease in Netherlands. Lancet 1999; 353:813-814.
6. Carlsson AK, Axelsson IE, Borulf SK, Bredberg AC, Ivarsson SA. Serological screening for celiac disease in healthy 2.5-year-old children in Sweden. Pediatrics 2001; 107:42-45.
7. Hoffenberg EJ, MacKenzie T, Barriga KJ, Eisenbarth GS, Bao F, Haas JE, et al. A prospective study of the incidence of childhood celiac disease. J Pediatr 2003; 143:308-314.
8. Ben Hariz M, Kallel-Sellami M, Kallel L, Lahmer A, Halioui S, Bouraoui S, et al. Prevalence of celiac disease in Tunisia: mass-screening study in schoolchildren. Eur J Gastroenterol Hepatol 2007; 19:687-694.
9. Greco L, Romino R, Coto I, Di Cosmo N, Percopo S, Maglio M, et al. The first large population-based twin study of celiac disease. Gut 2002; 50:624-628.
10. Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in US families. Am J Gastroenterol 2003; 98:377-381.
11. Bevan S, Popat S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K, et al. Contribution of the MHC region to the familial risk of celiac disease. J Med Genet 1999; 36:687-690.
12. Liu J, Juo SH, Holopainen P, Terwilliger J, Tong X, Grunn A, et al. Genomewide linkage analysis of celiac disease in Finnish families. Am J Hum Genet 2002; 70:51-59.
13. Bilbao JR, Martin-Pagola A, Vittoria JC, Zubillaga P, Ortiz L, Castaño L. HLA DRB1 and MHC class I chain related a haplotypes in Basques families with celiac disease. Tissue Antigens 2002; 60:71-76.
14. Boy MF, La Nasa G, Balestrieri A, Cherchi MV, Usai P. Distribution of HLA-DPB1, -DQB1 -DQA1 alleles among Sardinian celiac patients. Dis Markers 1995; 12:199-204.
15. Vidales C, Zubillaga P, Zubillage I, Alfonso-Sánchez MA. Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain. Hum Immunol 2004; 65:352-358.
16. Bouguerra F, Barbon MC, Eliaou JF, Debbabi A, Clot J, Khaldi F, et al. Synergistic effect of two heterodimers in susceptibility to celiac disease in Tunisia. Genet Epidemiol 1997; 14:413-422.
17. Ploski R, Ek J, Thorsby E, Sollid LM. On HLA-DQ (alpha10501, beta 10201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB10201. Tissue Antigens 1993; 41:173-177.
18. Silva EM, Fernandes MI, Galvao LC, Sawamura R, Donadi EA. Human leukocyte antigen class II alleles in white Brazilian patients with celiac disease. J Pediatr Gastroenterol Nutr 2000; 31:391-394.
19. Perez-Bravo F, Araya M, Mondragon A, Ŕos G, Alarcó n T, Roessler JL, et al. Genetic differences in HLA-DQA1 and DQB1 allelic distributions between celiac and control children in Santiago, Chilie. Hum Immunol 1999; 60:262-267.
20. Kaur G, Sarkar N, Bhanagar S, Kumar S, Rapthap CC, Bhan MK, et al. Paediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. Hum Immunol 2002; 63:677-682.
21. Greenbaum CJ, Schatz DA, Cuthbertson D, Zeidler A, Eisenbarth GS, Krischer JP. Islet cell antibody-positive relatives with human leukocyte antigen DQA10102, DQB10602: identification by the Diabetes Prevention Trial-type 1. J Clin Endocrinol Metab 2000; 85:1255-1260.
22. Mustalahti K, Holopainen P, Karell K, Maki M, Partanen J. Genetic dissection between silent and clinically diagnosed symptomatic forms of celiac disease in multiplex families. Dig Liver Dis 2002; 34:842-845.
23. Greco L, Percopo S, Clot F, Bouguerra F, Babron MC, Eliaou JF, et al. Lack of correlation between genotype and phenotype in celiac disease. J Pediatr Gastroenterol Nutr 1998; 26:286-290.
24. Jores RD, Frau F, Cucca F, Grazia Clemente M, Orrù S, Rais M, et al. M. HLA-DQB10201 homozygosis predisposes to severe intestinal damage in celiac disease. Scand J Gastroenterol 2007; 42:48-53.
25. Das G, Janeway CA. MHC specificity of iELs. Trends Immunol 2003; 24:88-93.
26. Lopez-Vazquez A, Rodrigo L, Fuentes D, Riestra S, Bousoño C, Garcia-Fernandez S, et al. MHC class I chain related gene A (MICA) modulates the development of celiac disease in patients with the high risk heterodimer DQA10501/DQB10201. Gut 2002; 50:336-340.
27. Lopez-Vazquez A, Fuentes D, Rodrigo L, Gonzá lez S, Moreno M, Fernández E, et al. MHC class I region plays a role in the development of diverse clinical forms of celiac disease in a saharawi population. Am J Gastroenterol 2004; 99:662-667.
28. Tinto N, Ciacci C, Calcagno G, Gennarelli D, Spampanato A, Farinaro E, et al. Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous. Dig Liver Dis 2008; 40:248-252.